Mouse Genome Informatics
cx1
    Epm2aTg(TcraK,TcrbK)TG-BFlv/Epm2a+
Tg(Ela1-TAg)18Bri/0

involves: C57BL/6 * CBA/J * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• at 10 weeks, focal perivascular infiltrate is detected
• some 10-20 week-old mice show diffuse immune infiltrate with tissue destruction; animals may show parenchymal infiltrate without tissue destruction or a primarily perivascular infiltrate

endocrine/exocrine glands
• at 10-12 weeks of age, prominent TAg-induced dysplasia is observed; atypia in cell nuclei and acinar architectural distortion are seen
• pancreas shows exocrine tissue destruction
• at 10 weeks, focal perivascular infiltrate is detected
• some 10-20 week-old mice show diffuse immune infiltrate with tissue destruction; animals may show parenchymal infiltrate without tissue destruction or a primarily perivascular infiltrate

digestive/alimentary system
• pancreas shows exocrine tissue destruction


Mouse Genome Informatics
tg2
    Tg(Ela1-TAg)18Bri/0
involves: C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• 99% of mice develop pancreatic exocrine tumors concisting of acinar cell carcinoma, undifferentiated carcinoma, cystic carcinoma, and mixed pattern tumors
• 3 islet cell carcinomas develop
• 77% of mice form benign or low-grade islet cell tumors
• most islet cell tumors are composed of beta cells while one expressed predominantly somatostatin
• most islet cell tumors are composed of beta cells

endocrine/exocrine glands
• infiltrate localized to perivascular region is detected

immune system
• infiltrate localized to perivascular region is detected

digestive/alimentary system

Mouse Models of Human Disease
OMIM IDRef(s)
Pancreatic Cancer 260350 J:76995