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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Ela1-TAg)18Bri
transgene insertion 18, Ralph L Brinster
MGI:2385657
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Epm2aTg(TcraK,TcrbK)TG-BFlv/Epm2a+
Tg(Ela1-TAg)18Bri/0
involves: C57BL/6 * CBA/J * SJL MGI:3766077
tg2
Tg(Ela1-TAg)18Bri/0 involves: C57BL/6 * SJL MGI:3766076


Genotype
MGI:3766077
cx1
Allelic
Composition
Epm2aTg(TcraK,TcrbK)TG-BFlv/Epm2a+
Tg(Ela1-TAg)18Bri/0
Genetic
Background
involves: C57BL/6 * CBA/J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epm2aTg(TcraK,TcrbK)TG-BFlv mutation (0 available); any Epm2a mutation (6 available)
Tg(Ela1-TAg)18Bri mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• at 10 weeks, focal perivascular infiltrate is detected (J:107545)
• some 10-20 week-old mice show diffuse immune infiltrate with tissue destruction; animals may show parenchymal infiltrate without tissue destruction or a primarily perivascular infiltrate (J:107545)
• at 10 weeks, focal perivascular infiltrate is detected (J:107545)
• some 10-20 week-old mice show diffuse immune infiltrate with tissue destruction; animals may show parenchymal infiltrate without tissue destruction or a primarily perivascular infiltrate (J:107545)

endocrine/exocrine glands
• at 10-12 weeks of age, prominent TAg-induced dysplasia is observed; atypia in cell nuclei and acinar architectural distortion are seen (J:107545)
• at 10-12 weeks of age, prominent TAg-induced dysplasia is observed; atypia in cell nuclei and acinar architectural distortion are seen (J:107545)
• pancreas shows exocrine tissue destruction (J:107545)
• pancreas shows exocrine tissue destruction (J:107545)
• at 10 weeks, focal perivascular infiltrate is detected (J:107545)
• some 10-20 week-old mice show diffuse immune infiltrate with tissue destruction; animals may show parenchymal infiltrate without tissue destruction or a primarily perivascular infiltrate (J:107545)
• at 10 weeks, focal perivascular infiltrate is detected (J:107545)
• some 10-20 week-old mice show diffuse immune infiltrate with tissue destruction; animals may show parenchymal infiltrate without tissue destruction or a primarily perivascular infiltrate (J:107545)

digestive/alimentary system
• pancreas shows exocrine tissue destruction (J:107545)
• pancreas shows exocrine tissue destruction (J:107545)




Genotype
MGI:3766076
tg2
Allelic
Composition
Tg(Ela1-TAg)18Bri/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• 99% of mice develop pancreatic exocrine tumors concisting of acinar cell carcinoma, undifferentiated carcinoma, cystic carcinoma, and mixed pattern tumors (J:76995)
• 3 islet cell carcinomas develop (J:76995)
• 99% of mice develop pancreatic exocrine tumors concisting of acinar cell carcinoma, undifferentiated carcinoma, cystic carcinoma, and mixed pattern tumors (J:76995)
• 3 islet cell carcinomas develop (J:76995)
• 77% of mice form benign or low-grade islet cell tumors (J:76995)
• most islet cell tumors are composed of beta cells while one expressed predominantly somatostatin (J:76995)
• 77% of mice form benign or low-grade islet cell tumors (J:76995)
• most islet cell tumors are composed of beta cells while one expressed predominantly somatostatin (J:76995)
• most islet cell tumors are composed of beta cells (J:76995)
• most islet cell tumors are composed of beta cells (J:76995)

endocrine/exocrine glands
• infiltrate localized to perivascular region is detected (J:107545)
• infiltrate localized to perivascular region is detected (J:107545)

immune system
• infiltrate localized to perivascular region is detected (J:107545)
• infiltrate localized to perivascular region is detected (J:107545)

digestive/alimentary system

Mouse Models of Human Disease
OMIM ID Ref(s)
Pancreatic Cancer 260350 J:76995





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory