Mouse Genome Informatics
hm1
    Mapttm1Hnd/Mapttm1Hnd
involves: 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• severity is reduced and seizure onset is delayed after pentylenetetrazole treatment compared to wild-type mice
• mice are resistant to kainate-induced seizures over a larger range of doses than wild-type mice
• neuronal cultures from E16 mice show less axonal extension than wild-type neurons; mutant neurons lag behind wild-type in development over initial 2 days in culture, then catch up, but total sum of minor processes/axonal lengths is less than wild-type
• between 4 and 7 days in culture, total dendritic length of mutant neurons is less than in wild-type; after 7 days in culture, neurons still lag behind wild-type showing more developmental delay

behavior/neurological
• severity is reduced and seizure onset is delayed after pentylenetetrazole treatment compared to wild-type mice
• mice are resistant to kainate-induced seizures over a larger range of doses than wild-type mice

cellular
• neuronal cultures from E16 mice show less axonal extension than wild-type neurons; mutant neurons lag behind wild-type in development over initial 2 days in culture, then catch up, but total sum of minor processes/axonal lengths is less than wild-type


Mouse Genome Informatics
ht2
    Mapttm1Hnd/Mapt+
involves: 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• severity is reduced and seizure onset is delayed after pentylenetetrazole treatment compared to wild-type mice
• mice are resistant to kainate-induced seizures over a larger range of doses than wild-type mice

nervous system
• severity is reduced and seizure onset is delayed after pentylenetetrazole treatment compared to wild-type mice
• mice are resistant to kainate-induced seizures over a larger range of doses than wild-type mice


Mouse Genome Informatics
cx3
    Mapttm1Hnd/Mapttm1Hnd
Tg(PDGFB-APPSwInd)20Lms/0

involves: 129X1/SvJ * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
N
• mice show normal spatial learning and object-recongition memory, at levels similar to non-transgenic controls (J:121330)
• mice show no signs of hyperactivity (J:121330)
• seizures are less severe and occur at longer latencies compared to transgenic mice with wild-type Mapt

nervous system
• seizures are less severe and occur at longer latencies compared to transgenic mice with wild-type Mapt
• at 4-7 months and 14-18 months, Abeta plaque deposition is observed, at levels the same as other transgenics heterozygous or wild-type for Mapt
• mice show neuritic dystrophy around amyloid plaques
• aberrant sprouting of hippocampal axons is observed in transgenic mice

cellular
• aberrant sprouting of hippocampal axons is observed in transgenic mice

homeostasis/metabolism
• at 4-7 months and 14-18 months, Abeta plaque deposition is observed, at levels the same as other transgenics heterozygous or wild-type for Mapt


Mouse Genome Informatics
cx4
    Mapttm1Hnd/Mapt+
Tg(PDGFB-APPSwInd)20Lms/0

involves: 129X1/SvJ * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
N
• mice show no signs of hyperactivity (J:121330)
• seizures are less severe and occur at longer latencies compared to transgenic mice with wild-type Mapt
• in the hidden platform version of the Morris water maze, non-trangenic controls, regardless of Mapt genotype learn the task over 3 days, whereas transgenic mice heterozygous for Mapttm1Hnd show show impaired learning compared to controls but less impairment than transgenic mice with normal Mapt expression
• in probe trials where the platform is removed, mice show delayed learning, compared to non transgenic controls or transgenic mice with wild-type Mapt, with more target than non-target crossings after 5 days of training

nervous system
• seizures are less severe and occur at longer latencies compared to transgenic mice with wild-type Mapt
• at 4-7 months and 14-18 months, Abeta plaque deposition is observed, at levels the same as other transgenics null or wild-type for Mapt
• mice show neuritic dystrophy around amyloid plaques
• aberrant sprouting of hippocampal axons is observed in transgenic mice

cellular
• aberrant sprouting of hippocampal axons is observed in transgenic mice

homeostasis/metabolism
• at 4-7 months and 14-18 months, Abeta plaque deposition is observed, at levels the same as other transgenics null or wild-type for Mapt