Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm1Hnd mutation
(7 available);
any
Mapt mutation
(428 available)
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nervous system
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• severity is reduced and seizure onset is delayed after pentylenetetrazole treatment compared to wild-type mice
• mice are resistant to kainate-induced seizures over a larger range of doses than wild-type mice
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• neuronal cultures from E16 mice show less axonal extension than wild-type neurons; mutant neurons lag behind wild-type in development over initial 2 days in culture, then catch up, but total sum of minor processes/axonal lengths is less than wild-type
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• between 4 and 7 days in culture, total dendritic length of mutant neurons is less than in wild-type; after 7 days in culture, neurons still lag behind wild-type showing more developmental delay
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behavior/neurological
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• severity is reduced and seizure onset is delayed after pentylenetetrazole treatment compared to wild-type mice
• mice are resistant to kainate-induced seizures over a larger range of doses than wild-type mice
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cellular
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• neuronal cultures from E16 mice show less axonal extension than wild-type neurons; mutant neurons lag behind wild-type in development over initial 2 days in culture, then catch up, but total sum of minor processes/axonal lengths is less than wild-type
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Allelic
Composition |
Mapttm1Hnd/Mapt+
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Genetic
Background |
involves: 129X1/SvJ * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm1Hnd mutation
(7 available);
any
Mapt mutation
(428 available)
|
|
|
behavior/neurological
|
|
• severity is reduced and seizure onset is delayed after pentylenetetrazole treatment compared to wild-type mice
• mice are resistant to kainate-induced seizures over a larger range of doses than wild-type mice
|
nervous system
|
|
• severity is reduced and seizure onset is delayed after pentylenetetrazole treatment compared to wild-type mice
• mice are resistant to kainate-induced seizures over a larger range of doses than wild-type mice
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behavior/neurological
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N |
• mice show normal spatial learning and object-recongition memory, at levels similar to non-transgenic controls
• mice show no signs of hyperactivity
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• seizures are less severe and occur at longer latencies compared to transgenic mice with wild-type Mapt
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nervous system
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• seizures are less severe and occur at longer latencies compared to transgenic mice with wild-type Mapt
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• at 4-7 months and 14-18 months, Abeta plaque deposition is observed, at levels the same as other transgenics heterozygous or wild-type for Mapt
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• mice show neuritic dystrophy around amyloid plaques
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• aberrant sprouting of hippocampal axons is observed in transgenic mice
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cellular
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• aberrant sprouting of hippocampal axons is observed in transgenic mice
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homeostasis/metabolism
behavior/neurological
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N |
• mice show no signs of hyperactivity
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• seizures are less severe and occur at longer latencies compared to transgenic mice with wild-type Mapt
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• in the hidden platform version of the Morris water maze, non-trangenic controls, regardless of Mapt genotype learn the task over 3 days, whereas transgenic mice heterozygous for Mapttm1Hnd show show impaired learning compared to controls but less impairment than transgenic mice with normal Mapt expression
• in probe trials where the platform is removed, mice show delayed learning, compared to non transgenic controls or transgenic mice with wild-type Mapt, with more target than non-target crossings after 5 days of training
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nervous system
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• seizures are less severe and occur at longer latencies compared to transgenic mice with wild-type Mapt
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• at 4-7 months and 14-18 months, Abeta plaque deposition is observed, at levels the same as other transgenics null or wild-type for Mapt
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• mice show neuritic dystrophy around amyloid plaques
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• aberrant sprouting of hippocampal axons is observed in transgenic mice
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cellular
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• aberrant sprouting of hippocampal axons is observed in transgenic mice
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homeostasis/metabolism
Analysis Tools