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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Prnp-MAPT)43Vle
transgene insertion 43, Virginia M Y Lee
MGI:2385566
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Prnp-MAPT)43Vle/Tg(Prnp-MAPT)43Vle involves: C57BL/6 * DBA/2 MGI:3663450
tg2
Tg(Prnp-MAPT)43Vle/0 involves: C57BL/6 * DBA/2 MGI:3663447


Genotype
MGI:3663450
tg1
Allelic
Composition
Tg(Prnp-MAPT)43Vle/Tg(Prnp-MAPT)43Vle
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prnp-MAPT)43Vle mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice die in utero or within three months (J:61052)
• mice die in utero or within three months (J:61052)
• mice die in utero or within three months (J:61052)
• mice die in utero or within three months (J:61052)




Genotype
MGI:3663447
tg2
Allelic
Composition
Tg(Prnp-MAPT)43Vle/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prnp-MAPT)43Vle mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• tau-positive spheroidal inclusions in spinal cord neurons are visible by 1 month of age (J:61052)
• size and number increases up to 6-9 months of age, but decreases in number by 12 months of age (J:61052)
• inclusions are the size of medium to large spinal cord neurons and some appear to arise within the proximal axons of spinal cord neurons (J:61052)
• spinal cord inclusions are most frequent at the grey-white matter junction (J:61052)
• spinal cord inclusions in line 43 are larger and more abundant than in line 7 (J:61052)
• tau-positive inclusions appear in cortical neurons and brainstem by 6 months of age (J:61052)
• inclusions in cortical neurons occur in proximal axons or somadendritic domains of neurons (J:61052)
• inclusions are visible in pontine neurons by 1 month of age (J:61052)
• tau deposits become increasingly insoluble with age (J:61052)
• tau-positive spheroidal inclusions in spinal cord neurons are visible by 1 month of age (J:61052)
• size and number increases up to 6-9 months of age, but decreases in number by 12 months of age (J:61052)
• inclusions are the size of medium to large spinal cord neurons and some appear to arise within the proximal axons of spinal cord neurons (J:61052)
• spinal cord inclusions are most frequent at the grey-white matter junction (J:61052)
• spinal cord inclusions in line 43 are larger and more abundant than in line 7 (J:61052)
• tau-positive inclusions appear in cortical neurons and brainstem by 6 months of age (J:61052)
• inclusions in cortical neurons occur in proximal axons or somadendritic domains of neurons (J:61052)
• inclusions are visible in pontine neurons by 1 month of age (J:61052)
• tau deposits become increasingly insoluble with age (J:61052)
• detectable after one month of age (J:61052)
• detectable after one month of age (J:61052)
• in addition to inclusions, vacuolar lesions are observed in older mice (J:61052)
• in addition to inclusions, vacuolar lesions are observed in older mice (J:61052)
• spinal cord ventral root contains irregularly shaped axons (J:61052)
• by 12 months of age endoneurial space in ventral root axons appears to increase (J:61052)
• spinal cord ventral root contains irregularly shaped axons (J:61052)
• by 12 months of age endoneurial space in ventral root axons appears to increase (J:61052)
• 20% decrease in number of ventral root axons by 12 months of age (J:61052)
• significant reduction in microtubule density by 12 months of age, although neurofilament density is unchanged (J:61052)
• 20% decrease in number of ventral root axons by 12 months of age (J:61052)
• significant reduction in microtubule density by 12 months of age, although neurofilament density is unchanged (J:61052)
• fast axonal transport of proteins is retarded as compared to wildtype (J:61052)
• fast axonal transport of proteins is retarded as compared to wildtype (J:61052)

behavior/neurological
• mice retract hindlimbs when lifted by the tail (J:61052)
• mice retract hindlimbs when lifted by the tail (J:61052)
• impaired ability to stand on slanted surface (J:61052)
• impaired ability to stand on slanted surface (J:61052)

growth/size/body
• mice weigh 30-40% less than normal littermates (J:61052)
• mice weigh 30-40% less than normal littermates (J:61052)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:61052
Frontotemporal Dementia; FTD 600274 J:61052





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory