All Phenotypes Cckbr<tm1Tom> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cckbr^tm1Tom/Cckbr^tm1Tom	B6.129S4-Cckbr^tm1Tom	MGI:3530251
hm2	Cckbr^tm1Tom/Cckbr^tm1Tom	involves: 129S4/SvJae	MGI:4821003
hm3	Cckbr^tm1Tom/Cckbr^tm1Tom	involves: 129S4/SvJae * C57BL/6	MGI:4820985
hm4	Cckbr^tm1Tom/Cckbr^tm1Tom	involves: 129S4/SvJae * C57BL/6J	MGI:4820984
ht5	Cckbr^tm1Tom/Cckbr⁺	B6.129S4-Cckbr^tm1Tom	MGI:4821132
cx6	Cckar^tm1Kym/Cckar^tm1Kym Cckbr^tm1Tom/Cckbr^tm1Tom	B6.129S4-Cckar^tm1Kym Cckbr^tm1Tom	MGI:4821093
cx7	Cckar^tm1Kym/Cckar^tm1Kym Cckbr^tm1Tom/Cckbr^tm1Tom	involves: 129S4/SvJae	MGI:4821005
cx8	Cckar^tm1Kym/Cckar^tm1Kym Cckbr^tm1Tom/Cckbr^tm1Tom	involves: 129S4/SvJae * C57BL/6J	MGI:3530257

Allelic Composition	Cckbr^tm1Tom/Cckbr^tm1Tom
Genetic Background	B6.129S4-Cckbr^tm1Tom

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cckbr^tm1Tom mutation (1 available); any Cckbr mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:92317 )

• isolated male mice fail to exhibit an increase in open arm entries or in number of line crossings, make fewer attempts to enter from the enclosed arm into the central square, spend more time in motion, and travel a greater distance compared with isolated male wild-type mice

• group housed male exhibit less digging compared than group housed male wild-type mice

decreased anxiety-related response ( J:92317 )

• isolated female mice exhibit an increase in number of open arm entries and fail to exhibit a decrease in number of closed arm entries compared with isolated wild-type female mice

increased anxiety-related response ( J:107934 )

• mice fewer entries into open arms than wild-type mice and Cckar^tm1Kym homozygotes

• mice spent less time in open arms and more time in enclosed arms than wild-type mice

• however, the number of entries into enclosed arms is normal

decreased grooming behavior ( J:92317 )

• in group housed male mice

hyporesponsive to tactile stimuli ( J:101295 )

• mice exhibit decreased mechanical sensitivity compared with wild-type mice that is not sensitive to L-365260 unlike in wild-type mice

• following sciatic nerve ligation, mice exhibit reduced inflammation and hyperemia in the spinal cord and fail to exhibit hyperalgesia compared with similarly treated wild-type mice

• however, naxolone treatment rescues mechanical sensitivity

abnormal nociception after inflammation ( J:101295 )

• following sciatic nerve ligation, mice exhibit reduced inflammation and hyperemia in the spinal cord and fail to exhibit hyperalgesia compared with similarly treated wild-type mice

growth/size/body

decreased body weight ( J:92317 )

• in isolated male mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:95791 )

N	• normal body temperature regulation in response to changes in ambient temperature and normal circadian rhythm of body temperature

cardiovascular system

abnormal blood circulation ( J:101295 )

• following sciatic nerve ligation, mice exhibit hyperemia in the spinal cord unlike similarly treated wild-type mice

Allelic Composition	Cckbr^tm1Tom/Cckbr^tm1Tom
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cckbr^tm1Tom mutation (1 available); any Cckbr mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

impaired gastric peristalsis ( J:101985 )

• mice exhibit delayed gastric emptying compared with wild-type mice that is not affected by treatment with CCK-8S unlike in wild-type mice

• mice treated with 5 mg/kg atropine exhibit delayed gastric emptying compared with similarly treated wild-type mice

homeostasis/metabolism

increased circulating gastrin level ( J:101985 )

increased energy expenditure ( J:96087 )

behavior/neurological

abnormal eating behavior ( J:96087 )

Allelic Composition	Cckbr^tm1Tom/Cckbr^tm1Tom
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cckbr^tm1Tom mutation (1 available); any Cckbr mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired behavioral response to cocaine ( J:107970 )

• cocaine-treated mice exhibit decreased activity compared with similarly treated wild-type mice

enhanced behavioral response to addictive substance ( J:107970 )

• amphetamine-treated mice exhibit increased activity compared with similarly treated wild-type mice

enhanced behavioral response to morphine ( J:107970 )

• morphine-treated mice exhibit increased activity compared with similarly treated wild-type mice

hyperactivity ( J:107970 )

• however, treatment with a dopamine receptor 1 antagonist had no effect on activity levels

• mice exhibit increased activity compared with wild-type mice

• treatment with the dopamine receptor 2 selective antagonist reduce activity unlike in similarly treated wild-type mice

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:107970 )

• treatment with the dopamine receptor 2 selective antagonist reduce activity unlike in similarly treated wild-type mice

• however, treatment with a dopamine receptor 1 antagonist had no effect on activity levels

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:106503 )

• in a traction test, mice fail to grasp the bar with at least one hind paw unlike wild-type mice

• mice exhibit decreased spontaneous alternation in a Y maze compared with wild-type mice

• however, mice exhibit normal anxiety and nociception

increased fluid intake ( J:143853 )

• in LPS-treated mice compared with similarly treated wild-type mice

increased food intake ( J:143853 )

• in LPS-treated mice compared with similarly treated wild-type mice

decreased anxiety-related response ( J:101905 )

• mice make more transitions between the black and white boxes compared with wild-type mice

• mice exhibit an increase number of head dips in an elevated plus-maze compared with wild-type mice

• however, there is no difference in the number of entries into the open and closed arms and no difference in the time spent in the open arms

impaired coordination ( J:106503 )

• in a rotarod test

hyperactivity ( J:106503 , J:143853 )

• mice exhibit increased activity in an actimeter compared with wild-type mice (J:106503)

• mice exhibit increased activity in an elevated plus maze compared with wild-type mice without a chance in anxious reactivity (J:106503)

• in LPS-treated mice compared with similarly treated wild-type mice (J:143853)

digestive/alimentary system

abnormal stomach mucosa morphology ( J:35876 )

• mice exhibit atrophy of gastric mucosa unlike wild-type mice

• mice exhibit a thinning of the corpus and fundic mucosa unlike wild-type mice

• treatment with proton pump inhibitor does increase gastric mucosa or eliminate mucosa atrophy unlike in wild-type mice

• mice exhibit a thinning of the isthmus and neck regions of the stomach compared to in wild-type mice

• mice exhibit a decrease in parietal and chromogranin-A+ entero-chromaffin-like cells compared to in wild-type mice

• however, the thickness of the gastric pit region is normal

small stomach ( J:35876 )

• stomach wet weight is decreased compared to in wild-type mice

abnormal digestive system physiology ( J:35876 )

• proliferation of parietal and chromogranin-A+ entero-chromaffin-like cells is decreased compared to in wild-type mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:142455 )

N	• juvenile and mature mice exhibit normal iron absorption

increased circulating gastrin level ( J:35876 , J:142455 )

• mice exhibit a 5 times increase in plasma gastrin levels compared with wild-type mice (J:35876)

• gastrin levels are insensitive to proton pump inhibitor treatment unlike in wild-type mice (J:35876)

• at 4 and 10 weeks (J:142455)

abnormal circulating iron level ( J:142455 )

• however, iron levels at 10 weeks are normal

decreased circulating ferritin level ( J:142455 )

• juvenile mice exhibit a 0.23-fold reduction in plasma ferritin levels compared with wild-type mice

decreased circulating unsaturated transferrin level ( J:142455 )

• juvenile mice exhibit a 1.5-fold increase in transferrin saturation compared with wild-type mice

impaired febrile response ( J:143853 )

• in LPS-treated mice compared with similarly treated wild-type mice

increased liver iron level ( J:142455 )

• 2-fold at 10 weeks

immune system

decreased susceptibility to endotoxin shock ( J:143853 )

• LPS treated mice exhibit attenuated sickness responses (fever, hypoactivity, cachexia, anorexia, and adipsia) compared with wild-type mice

liver/biliary system

increased liver iron level ( J:142455 )

• 2-fold at 10 weeks

nervous system

abnormal excitatory postsynaptic currents ( J:159855 )

• CCK-8-treated mice fail to exhibit a change in AMPA excitatory postsynaptic currents unlike in similarly treated wild-type mice

Allelic Composition	Cckbr^tm1Tom/Cckbr⁺
Genetic Background	B6.129S4-Cckbr^tm1Tom

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cckbr^tm1Tom mutation (1 available); any Cckbr mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyporesponsive to tactile stimuli ( J:101295 )

• mice exhibit decreased mechanical sensitivity compared with wild-type mice that is not sensitive to L-365260 unlike in wild-type mice

• however, naxolone treatment rescues mechanical sensitivity

Allelic Composition	Cckar^tm1Kym/Cckar^tm1Kym Cckbr^tm1Tom/Cckbr^tm1Tom
Genetic Background	B6.129S4-Cckar^tm1Kym Cckbr^tm1Tom

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cckar^tm1Kym mutation (1 available); any Cckar mutation (41 available)
Cckbr^tm1Tom mutation (1 available); any Cckbr mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:107934 )

• mice spend more time in enclosed arms than wild-type mice

growth/size/body

decreased body weight ( J:107934 )

Allelic Composition	Cckar^tm1Kym/Cckar^tm1Kym Cckbr^tm1Tom/Cckbr^tm1Tom
Genetic Background	involves: 129S4/SvJae

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased pancreas weight ( J:96087 )

decreased body weight ( J:96087 , J:101985 )

• at one measurement, mice weighed significantly less than wild-type mice (J:96087)

• however, no signifiance was detected in body weight at a different measurement (J:96087)

increased kidney weight ( J:96087 )

digestive/alimentary system

impaired gastric peristalsis ( J:101985 )

• mice exhibit delayed gastric emptying compared with wild-type mice that is not affected by treatment with CCK-8S unlike in wild-type mice

• mice treated with 5 mg/kg atropine exhibit delayed gastric emptying compared with similarly treated Cckar^tm1Kym homozygotes

homeostasis/metabolism

increased energy expenditure ( J:96087 )

behavior/neurological

abnormal eating behavior ( J:96087 )

endocrine/exocrine glands

increased pancreas weight ( J:96087 )

renal/urinary system

increased kidney weight ( J:96087 )

Allelic Composition	Cckar^tm1Kym/Cckar^tm1Kym Cckbr^tm1Tom/Cckbr^tm1Tom
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:95791 )

• double homozygous mutants weighed significantly less than single homozygous or wildtype mice

homeostasis/metabolism

abnormal body temperature homeostasis ( J:95791 )

• regulation of the core body temperature to changes in ambient temperature was disrupted compared to wild-type or homozygous Cckbr mutants, however the circadian rhythm of body temperature was normal

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