Mouse Genome Informatics
hm1
    Lta/Tnftm1Jods/Lta/Tnftm1Jods
C57BL/6-Lta/Tnftm1Jods
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• spleen white pulp micro-architecture is severely disrupted
• mice are resistant to the development of experimental autoimmune encephalomyelitis

hematopoietic system
• spleen white pulp micro-architecture is severely disrupted


Mouse Genome Informatics
hm2
    Lta/Tnftm1Jods/Lta/Tnftm1Jods
C57BL/6J-Lta/Tnftm1Jods
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• 4-5 fold increase in leukocytosis
• B and T cell areas poorly demarcated and poorly organized
• deficiency of IgM-high IgD-low B cells
• deficient in all serum Ig isotypes except IgM

immune system
• 4-5 fold increase in leukocytosis
• deficiency of IgM-high IgD-low B cells
• B and T cell areas poorly demarcated and poorly organized
• deficient in all serum Ig isotypes except IgM
• lacks lymph nodes


Mouse Genome Informatics
hm3
    Lta/Tnftm1Jods/Lta/Tnftm1Jods
involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• fewer IL17+ thymic gamma-delta T cells in response to PMA and ionomycin stimulation
• however, the number of thymic IFN-gamma+ gamma-delta T cells

immune system
• fewer IL17+ thymic gamma-delta T cells in response to PMA and ionomycin stimulation
• however, the number of thymic IFN-gamma+ gamma-delta T cells