Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnftm1Jods mutation
(0 available);
any
Tnf mutation
(46 available)
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immune system
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• spleen white pulp micro-architecture is severely disrupted
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• mice are resistant to the development of experimental autoimmune encephalomyelitis
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hematopoietic system
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• spleen white pulp micro-architecture is severely disrupted
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnftm1Jods mutation
(0 available);
any
Tnf mutation
(46 available)
|
|
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hematopoietic system
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• 4-5 fold increase in leukocytosis
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• B and T cell areas poorly demarcated and poorly organized
• deficiency of IgM-high IgD-low B cells
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• deficient in all serum Ig isotypes except IgM
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immune system
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• 4-5 fold increase in leukocytosis
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• B and T cell areas poorly demarcated and poorly organized
• deficiency of IgM-high IgD-low B cells
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• deficient in all serum Ig isotypes except IgM
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growth/size/body
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• B and T cell areas poorly demarcated and poorly organized
• deficiency of IgM-high IgD-low B cells
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnftm1Jods mutation
(0 available);
any
Tnf mutation
(46 available)
|
|
|
hematopoietic system
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• fewer IL17+ thymic gamma-delta T cells in response to PMA and ionomycin stimulation
• however, the number of thymic IFN-gamma+ gamma-delta T cells
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immune system
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• fewer IL17+ thymic gamma-delta T cells in response to PMA and ionomycin stimulation
• however, the number of thymic IFN-gamma+ gamma-delta T cells
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