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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lta/Tnftm1Jods
targeted mutation 1, Jonathon D Sedgwick
MGI:2384506
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lta/Tnftm1Jods/Lta/Tnftm1Jods C57BL/6-Lta/Tnftm1Jods MGI:3768359
hm2
Lta/Tnftm1Jods/Lta/Tnftm1Jods C57BL/6J-Lta/Tnftm1Jods MGI:3052842
hm3
Lta/Tnftm1Jods/Lta/Tnftm1Jods involves: C57BL/6 MGI:5441222


Genotype
MGI:3768359
hm1
Allelic
Composition
Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic
Background
C57BL/6-Lta/Tnftm1Jods
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnftm1Jods mutation (0 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• spleen white pulp micro-architecture is severely disrupted (J:78229)
• spleen white pulp micro-architecture is severely disrupted (J:78229)
• mice are resistant to the development of experimental autoimmune encephalomyelitis (J:47428)
• mice are resistant to the development of experimental autoimmune encephalomyelitis (J:47428)

hematopoietic system
• spleen white pulp micro-architecture is severely disrupted (J:78229)
• spleen white pulp micro-architecture is severely disrupted (J:78229)




Genotype
MGI:3052842
hm2
Allelic
Composition
Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic
Background
C57BL/6J-Lta/Tnftm1Jods
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnftm1Jods mutation (0 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• 4-5 fold increase in leukocytosis (J:43602)
• 4-5 fold increase in leukocytosis (J:43602)
• B and T cell areas poorly demarcated and poorly organized (J:43602)
• deficiency of IgM-high IgD-low B cells (J:43602)
• B and T cell areas poorly demarcated and poorly organized (J:43602)
• deficiency of IgM-high IgD-low B cells (J:43602)
• deficient in all serum Ig isotypes except IgM (J:43602)
• deficient in all serum Ig isotypes except IgM (J:43602)

immune system
• 4-5 fold increase in leukocytosis (J:43602)
• 4-5 fold increase in leukocytosis (J:43602)
• B and T cell areas poorly demarcated and poorly organized (J:43602)
• deficiency of IgM-high IgD-low B cells (J:43602)
• B and T cell areas poorly demarcated and poorly organized (J:43602)
• deficiency of IgM-high IgD-low B cells (J:43602)
• deficient in all serum Ig isotypes except IgM (J:43602)
• deficient in all serum Ig isotypes except IgM (J:43602)
• lacks lymph nodes (J:43602)
• lacks lymph nodes (J:43602)




Genotype
MGI:5441222
hm3
Allelic
Composition
Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnftm1Jods mutation (0 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• fewer IL17+ thymic gamma-delta T cells in response to PMA and ionomycin stimulation (J:169863)
• however, the number of thymic IFN-gamma+ gamma-delta T cells (J:169863)
• fewer IL17+ thymic gamma-delta T cells in response to PMA and ionomycin stimulation (J:169863)
• however, the number of thymic IFN-gamma+ gamma-delta T cells (J:169863)

immune system
• fewer IL17+ thymic gamma-delta T cells in response to PMA and ionomycin stimulation (J:169863)
• however, the number of thymic IFN-gamma+ gamma-delta T cells (J:169863)
• fewer IL17+ thymic gamma-delta T cells in response to PMA and ionomycin stimulation (J:169863)
• however, the number of thymic IFN-gamma+ gamma-delta T cells (J:169863)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory