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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lta/Tnftm1Jods
targeted mutation 1, Jonathon D Sedgwick
MGI:2384506
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lta/Tnftm1Jods/Lta/Tnftm1Jods C57BL/6-Lta/Tnftm1Jods MGI:3768359
hm2
Lta/Tnftm1Jods/Lta/Tnftm1Jods C57BL/6J-Lta/Tnftm1Jods MGI:3052842
hm3
Lta/Tnftm1Jods/Lta/Tnftm1Jods involves: C57BL/6 MGI:5441222


Genotype
MGI:3768359
hm1
Allelic
Composition
Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic
Background
C57BL/6-Lta/Tnftm1Jods
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnftm1Jods mutation (0 available); any Tnf mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• spleen white pulp micro-architecture is severely disrupted
• mice are resistant to the development of experimental autoimmune encephalomyelitis

hematopoietic system
• spleen white pulp micro-architecture is severely disrupted




Genotype
MGI:3052842
hm2
Allelic
Composition
Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic
Background
C57BL/6J-Lta/Tnftm1Jods
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnftm1Jods mutation (0 available); any Tnf mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• 4-5 fold increase in leukocytosis
• B and T cell areas poorly demarcated and poorly organized
• deficiency of IgM-high IgD-low B cells
• deficient in all serum Ig isotypes except IgM

immune system
• 4-5 fold increase in leukocytosis
• B and T cell areas poorly demarcated and poorly organized
• deficiency of IgM-high IgD-low B cells
• deficient in all serum Ig isotypes except IgM
• lacks lymph nodes




Genotype
MGI:5441222
hm3
Allelic
Composition
Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnftm1Jods mutation (0 available); any Tnf mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• fewer IL17+ thymic gamma-delta T cells in response to PMA and ionomycin stimulation
• however, the number of thymic IFN-gamma+ gamma-delta T cells

immune system
• fewer IL17+ thymic gamma-delta T cells in response to PMA and ionomycin stimulation
• however, the number of thymic IFN-gamma+ gamma-delta T cells





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory