Analysis Tools
nervous system
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• the number of of proprioceptive afferent cell bodies within the dorsal root ganglia of L1 to L5 and proprioceptive afferent cell body projections are reduced
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Allele Symbol Allele Name Allele ID |
Etv1tm2Tmj targeted mutation 2, Thomas M Jessell MGI:2384496 |
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| Summary |
10 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the number of of proprioceptive afferent cell bodies within the dorsal root ganglia of L1 to L5 and proprioceptive afferent cell body projections are reduced
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• golgi tendon organ numbers are decreased in the soleus (by 77%), medial gastrocnemius (by 64%), and extensor hallucis longus (by 26%)
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• in some cases the soleus lacks golgi tendon organs
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• spindle density is increased in dorsal and to a lesser extent in ventral crural muscles
• at P20-22, average spindle number is increased by 57% in the soleus, by 80% in the medial gastrocnemius, and by 26% in the extensor hallucis longus
• however, spindle numbers are decreased in proximal hindlimb muscles with dorsal muscles more severely affected than ventral muscles resulting in an overall decrease in spindle density in the hindlimbs
• about 69% of spindles contain fewer than the normal 4 intrafusal fibers and these spindles also have a shorter capsule and smaller periaxial fluid space
• the missing intrafusal fibers are generally the later forming chain fibers
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• myelinated nerve fibers in the soleus and medial gastrocnemius are decreased by 12-13% compared to wild-type
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• the proprioceptive branch of the soleus muscle nerve has 12% fewer myelinated fibers, innervates more spindles and fewer golgi tendon organs, and contains more group Ia afferents and fewer group Ib afferents
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• only 0.2% of 9400 neuron profiles show calbindin 2 expression compared to 5.6% of 700 neuron profiles in wild-type mice
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• fewer dorsal root ganglion neurons and axonal projections express calbindin 2
(J:75311)
• about a 14% and 23% decrease in neuron numbers are seen in the L4 and L3 dorsal root ganglia, respectively
(J:75311)
• a 25% and 32% decrease in myelinated nerve fiber numbers are seen in the L4 and L3 dorsal root ganglia, respectively
(J:75311)
• absent from the crus at P0-P1
(J:107207)
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• both L3 and L4 ventral spinal roots contain fewer small caliber motor axons (19% of the myelinated axon population) compared to wild-type mice (38% of the myelinated axon population)
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• golgi tendon organ numbers are decreased in the soleus (by 77%), medial gastrocnemius (by 64%), and extensor hallucis longus (by 26%)
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• in some cases the soleus lacks golgi tendon organs
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• spindle density is increased in dorsal and to a lesser extent in ventral crural muscles
• at P20-22, average spindle number is increased by 57% in the soleus, by 80% in the medial gastrocnemius, and by 26% in the extensor hallucis longus
• however, spindle numbers are decreased in proximal hindlimb muscles with dorsal muscles more severely affected than ventral muscles resulting in an overall decrease in spindle density in the hindlimbs
• about 69% of spindles contain fewer than the normal 4 intrafusal fibers and these spindles also have a shorter capsule and smaller periaxial fluid space
• the missing intrafusal fibers are generally the later forming chain fibers
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die between 3 and 5 weeks of age
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• abnormal flexor-extensor posturing of the limbs
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• distal hindlimb muscles show a 20-25% decrease in golgi tendon organ numbers
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• distal hindlimb muscles show a 20-30% increase in spindle numbers
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• 15-17% decrease in pacinian corpuscle numbers in the crus at P0-P1
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• about a 11% and 13% decrease in neuron numbers are seen in the L4 and L3 dorsal root ganglia, respectively
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• slightly smaller through the first 3 weeks of life
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• distal hindlimb muscles show a 20-25% decrease in golgi tendon organ numbers
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• distal hindlimb muscles show a 20-30% increase in spindle numbers
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice are indistinguishable from wild-type in the number of proprioceptive afferent cell bodies within the dorsal root ganglia of L1 to L5
• proprioceptive afferent cell body projections are also normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the interosseous nerve is present but thinner than in wild-type mice
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• 20% decrease in pacinian corpuscle numbers in the crus at P0-P1
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• remaining corpuscles are smaller than wild-type but structurally similar
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants exhibit loss of about 65% of WGA-positive muscle spindles relative to controls
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• mutants exhibit loss of about 65% of WGA-positive muscle spindles relative to controls
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• number of wheat germ agglutinin-positive (WGA) proprioceptive sensory neurons in L2 and L5 DRG is significantly reduced (to 20% of control)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• absent from proximal and distal muscles in newborn double homozygotes
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• spindles are absent from proximal and distal muscles in newborn double homozygotes
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• absent from proximal and distal muscles in newborn double homozygotes
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• spindles are absent from proximal and distal muscles in newborn double homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• number of proprioceptive sensory neurons (pSNs) is increased by 2-fold compared to wild-type controls
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• about 30% of pSNs in the rostral lumbar DRG have cell body diameters in the wild-type range, with 70% having smaller somatic diameters
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in P5-6 mutants, almost complete depletion in the laterally-targeted pSN axon fascicle at T9, L2 and L5 spinal cord levels; medially-oriented pSN axons are greatly reduced in number at all segmental levels compared to controls
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• in P5-6 mutants, almost complete depletion in the laterally-targeted pSN axon fascicle at T9, L2 and L5 spinal cord levels; medially-oriented pSN axons are greatly reduced in number at all segmental levels compared to controls
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• number of proprioceptive sensory neurons (pSNs) detected in DRGs at level of L2 are decreased by 30% at P0 and by P10, there is 80% loss; at L5 levels, pSN number is decreased by 40% at P0 and P10
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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