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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Etv1tm2Tmj
targeted mutation 2, Thomas M Jessell
MGI:2384496
Summary 10 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Etv1tm2Tmj/Etv1tm2Tmj involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:3716102
hm2
Etv1tm2Tmj/Etv1tm2Tmj involves: 129S1/Sv MGI:3621018
hm3
Etv1tm2Tmj/Etv1tm2Tmj involves: 129S1/Sv * C57BL/6J MGI:3621014
ht4
Etv1tm2Tmj/Etv1+ involves: 129S1/Sv MGI:3621019
ht5
Etv1tm1(Ewsr1/Etv4)Arbr/Etv1tm2Tmj involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:3716101
cx6
Etv1tm2Tmj/Etv1+
Etv4tm1Arbr/Etv4+
involves: 129S1/Sv MGI:3621024
cx7
Etv1tm1Tmj/Etv1tm2Tmj
Tg(EGR3-WGA)1Tmj/0
involves: 129S1/Sv MGI:5506525
cx8
Etv1tm2Tmj/Etv1tm2Tmj
Ntf3tm1Lfr/Ntf3tm1Lfr
involves: 129S1/Sv * 129S2/SvPas MGI:3621020
cx9
Baxtm1Sjk/Baxtm1Sjk
Etv1tm2Tmj/Etv1tm2Tmj
involves: 129S1/Sv * 129X1/SvJ MGI:5506523
cx10
Etv1tm2Tmj/Etv1tm2Tmj
Tg(Ntrk3-EGFP)BM45Gsat/0
involves: 129S1/Sv * FVB/N MGI:5506522


Genotype
MGI:3716102
hm1
Allelic
Composition
Etv1tm2Tmj/Etv1tm2Tmj
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv1tm2Tmj mutation (0 available); any Etv1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the number of of proprioceptive afferent cell bodies within the dorsal root ganglia of L1 to L5 and proprioceptive afferent cell body projections are reduced




Genotype
MGI:3621018
hm2
Allelic
Composition
Etv1tm2Tmj/Etv1tm2Tmj
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv1tm2Tmj mutation (0 available); any Etv1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• golgi tendon organ numbers are decreased in the soleus (by 77%), medial gastrocnemius (by 64%), and extensor hallucis longus (by 26%)
• in some cases the soleus lacks golgi tendon organs
• spindle density is increased in dorsal and to a lesser extent in ventral crural muscles
• at P20-22, average spindle number is increased by 57% in the soleus, by 80% in the medial gastrocnemius, and by 26% in the extensor hallucis longus
• however, spindle numbers are decreased in proximal hindlimb muscles with dorsal muscles more severely affected than ventral muscles resulting in an overall decrease in spindle density in the hindlimbs
• about 69% of spindles contain fewer than the normal 4 intrafusal fibers and these spindles also have a shorter capsule and smaller periaxial fluid space
• the missing intrafusal fibers are generally the later forming chain fibers
• myelinated nerve fibers in the soleus and medial gastrocnemius are decreased by 12-13% compared to wild-type
• the proprioceptive branch of the soleus muscle nerve has 12% fewer myelinated fibers, innervates more spindles and fewer golgi tendon organs, and contains more group Ia afferents and fewer group Ib afferents
• only 0.2% of 9400 neuron profiles show calbindin 2 expression compared to 5.6% of 700 neuron profiles in wild-type mice
• fewer dorsal root ganglion neurons and axonal projections express calbindin 2 (J:75311)
• about a 14% and 23% decrease in neuron numbers are seen in the L4 and L3 dorsal root ganglia, respectively (J:75311)
• a 25% and 32% decrease in myelinated nerve fiber numbers are seen in the L4 and L3 dorsal root ganglia, respectively (J:75311)
• absent from the crus at P0-P1 (J:107207)
• both L3 and L4 ventral spinal roots contain fewer small caliber motor axons (19% of the myelinated axon population) compared to wild-type mice (38% of the myelinated axon population)

muscle
• golgi tendon organ numbers are decreased in the soleus (by 77%), medial gastrocnemius (by 64%), and extensor hallucis longus (by 26%)
• in some cases the soleus lacks golgi tendon organs
• spindle density is increased in dorsal and to a lesser extent in ventral crural muscles
• at P20-22, average spindle number is increased by 57% in the soleus, by 80% in the medial gastrocnemius, and by 26% in the extensor hallucis longus
• however, spindle numbers are decreased in proximal hindlimb muscles with dorsal muscles more severely affected than ventral muscles resulting in an overall decrease in spindle density in the hindlimbs
• about 69% of spindles contain fewer than the normal 4 intrafusal fibers and these spindles also have a shorter capsule and smaller periaxial fluid space
• the missing intrafusal fibers are generally the later forming chain fibers




Genotype
MGI:3621014
hm3
Allelic
Composition
Etv1tm2Tmj/Etv1tm2Tmj
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv1tm2Tmj mutation (0 available); any Etv1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die between 3 and 5 weeks of age

behavior/neurological
• limb ataxia
• abnormal flexor-extensor posturing of the limbs




Genotype
MGI:3621019
ht4
Allelic
Composition
Etv1tm2Tmj/Etv1+
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv1tm2Tmj mutation (0 available); any Etv1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• distal hindlimb muscles show a 20-25% decrease in golgi tendon organ numbers
• distal hindlimb muscles show a 20-30% increase in spindle numbers
• 15-17% decrease in pacinian corpuscle numbers in the crus at P0-P1
• about a 11% and 13% decrease in neuron numbers are seen in the L4 and L3 dorsal root ganglia, respectively

growth/size/body
• slightly smaller through the first 3 weeks of life

muscle
• distal hindlimb muscles show a 20-25% decrease in golgi tendon organ numbers
• distal hindlimb muscles show a 20-30% increase in spindle numbers




Genotype
MGI:3716101
ht5
Allelic
Composition
Etv1tm1(Ewsr1/Etv4)Arbr/Etv1tm2Tmj
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv1tm1(Ewsr1/Etv4)Arbr mutation (0 available); any Etv1 mutation (30 available)
Etv1tm2Tmj mutation (0 available); any Etv1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice are indistinguishable from wild-type in the number of proprioceptive afferent cell bodies within the dorsal root ganglia of L1 to L5
• proprioceptive afferent cell body projections are also normal




Genotype
MGI:3621024
cx6
Allelic
Composition
Etv1tm2Tmj/Etv1+
Etv4tm1Arbr/Etv4+
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv1tm2Tmj mutation (0 available); any Etv1 mutation (30 available)
Etv4tm1Arbr mutation (0 available); any Etv4 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the interosseous nerve is present but thinner than in wild-type mice
• 20% decrease in pacinian corpuscle numbers in the crus at P0-P1
• remaining corpuscles are smaller than wild-type but structurally similar




Genotype
MGI:5506525
cx7
Allelic
Composition
Etv1tm1Tmj/Etv1tm2Tmj
Tg(EGR3-WGA)1Tmj/0
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv1tm1Tmj mutation (0 available); any Etv1 mutation (30 available)
Etv1tm2Tmj mutation (0 available); any Etv1 mutation (30 available)
Tg(EGR3-WGA)1Tmj mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• mutants exhibit loss of about 65% of WGA-positive muscle spindles relative to controls

nervous system
• mutants exhibit loss of about 65% of WGA-positive muscle spindles relative to controls
• number of wheat germ agglutinin-positive (WGA) proprioceptive sensory neurons in L2 and L5 DRG is significantly reduced (to 20% of control)




Genotype
MGI:3621020
cx8
Allelic
Composition
Etv1tm2Tmj/Etv1tm2Tmj
Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic
Background
involves: 129S1/Sv * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv1tm2Tmj mutation (0 available); any Etv1 mutation (30 available)
Ntf3tm1Lfr mutation (1 available); any Ntf3 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• absent from proximal and distal muscles in newborn double homozygotes
• spindles are absent from proximal and distal muscles in newborn double homozygotes

muscle
• absent from proximal and distal muscles in newborn double homozygotes
• spindles are absent from proximal and distal muscles in newborn double homozygotes




Genotype
MGI:5506523
cx9
Allelic
Composition
Baxtm1Sjk/Baxtm1Sjk
Etv1tm2Tmj/Etv1tm2Tmj
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Baxtm1Sjk mutation (1 available); any Bax mutation (24 available)
Etv1tm2Tmj mutation (0 available); any Etv1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• number of proprioceptive sensory neurons (pSNs) is increased by 2-fold compared to wild-type controls
• about 30% of pSNs in the rostral lumbar DRG have cell body diameters in the wild-type range, with 70% having smaller somatic diameters




Genotype
MGI:5506522
cx10
Allelic
Composition
Etv1tm2Tmj/Etv1tm2Tmj
Tg(Ntrk3-EGFP)BM45Gsat/0
Genetic
Background
involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv1tm2Tmj mutation (0 available); any Etv1 mutation (30 available)
Tg(Ntrk3-EGFP)BM45Gsat mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• in P5-6 mutants, almost complete depletion in the laterally-targeted pSN axon fascicle at T9, L2 and L5 spinal cord levels; medially-oriented pSN axons are greatly reduced in number at all segmental levels compared to controls

nervous system
• in P5-6 mutants, almost complete depletion in the laterally-targeted pSN axon fascicle at T9, L2 and L5 spinal cord levels; medially-oriented pSN axons are greatly reduced in number at all segmental levels compared to controls
• number of proprioceptive sensory neurons (pSNs) detected in DRGs at level of L2 are decreased by 30% at P0 and by P10, there is 80% loss; at L5 levels, pSN number is decreased by 40% at P0 and P10





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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory