Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc8a1tm1Hssh mutation
(0 available);
any
Slc8a1 mutation
(55 available)
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mortality/aging
cardiovascular system
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• a compact nonvascularized cell layer is seen in place of the normal capillary bed
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• increased apoptosis is seen in the myocardium
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• at E9.0 and E10.5, heart rate is reduced to about 4 and 0 bpm compared to 72 and 76 bpm in wild-type and 46 and 57 bpm in partially rescued embryos
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embryo
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• a compact nonvascularized cell layer is seen in place of the normal capillary bed
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• the mesoderm and endoderm are separate with few areas of contact
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• no definitive vasculature is present at E9.5; however some primitive vascular cells are present
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muscle
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• increased apoptosis is seen in the myocardium
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc8a1tm1Hssh mutation
(0 available);
any
Slc8a1 mutation
(55 available)
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mortality/aging
cardiovascular system
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• at E9.5 inner trabeculation is poorly developed
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• the heart loops normally but fails to develop further with only thin atrial and ventricular walls present at E9.0
• at E8.5-E9.5, increased apoptosis is seen in the myocardium; however no significant difference is seen in myocardial proliferation
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• at E9.0 the atrial wall is thin
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• at E9.5 the endocardium is less complex
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• at E9.0 and E9.5 the ventricular wall is thin with irregularly arranged cardiomyocytes
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• at E9.0, only weak atrial contractions are seen and the heart rate is 3.8 +/- 1.5 bpm compared to 53.1 +/- 5.9 bpm in wild-type mice
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embryo
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• at about E9.0; however, development of the neural tube, somites, head folds, and limb buds, and hematopoiesis are normal until E9.0
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muscle
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• at E9.5 inner trabeculation is poorly developed
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cellular
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc8a1tm1Hssh mutation
(0 available);
any
Slc8a1 mutation
(55 available)
Tg(Myh6-SLC8A1)AMord mutation
(0 available)
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mortality/aging
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• between E10.5 and E11.5, about 1 day longer than null mice without the transgene
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cardiovascular system
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• a compact nonvascularized cell layer is seen in place of the normal capillary bed
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• seen at E9.5; however no increase in apoptosis is seen in the myocardium unlike in null mice without the transgene
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• at E9.0 and E10.5, heart rate is reduced to about 46 and 57 bpm compared to 72 and 76 bpm in wild-type but increased compared to null mice without the transgene (about 4 and 0 bpm)
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embryo
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• a compact nonvascularized cell layer is seen in place of the normal capillary bed
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• begins around E9.0; however, the increased number of somites and presence of a forelimb bud at E10.5 indicate that the partially rescued embryos develop beyond E9.0 when null embryos without the transgene stop developing
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• the mesoderm and endoderm are separate with few areas of contact
• at E9.5-E10.5, the yolk sac is wrinkled, shrunken, and anemic
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• no definitive vasculature is present at E9.5; however some primitive vascular cells are present and hematopoiesis is normal
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growth/size/body
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• begins around E9.0; however, the increased number of somites and presence of a forelimb bud at E10.5 indicate that the partially rescued embryos develop beyond E9.0 when null embryos without the transgene stop developing
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Analysis Tools