All Phenotypes Mlh3<tm1Lpkn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mlh3^tm1Lpkn
targeted mutation 1, Steven M Lipkin
MGI:2384218

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mlh3^tm1Lpkn/Mlh3^tm1Lpkn	involves: 129S/SvEv	MGI:2663891

Allelic Composition	Mlh3^tm1Lpkn/Mlh3^tm1Lpkn
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlh3^tm1Lpkn mutation (1 available); any Mlh3 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

small testis ( J:78200 )

abnormal gametogenesis ( J:78200 )

• germ cell apoptosis following meiotic defects

azoospermia ( J:78200 )

abnormal female meiosis ( J:78200 )

• 7% of oocytes progressed to the 2 cell stage

abnormal male meiosis ( J:78200 )

• some spermatocytes arrest at pachytene

• most spermatocytes progressed to metaphase at which point they showed missegregation and aneuploidy

female infertility ( J:78200 )

male infertility ( J:78200 )

endocrine/exocrine glands

small testis ( J:78200 )

cellular

azoospermia ( J:78200 )

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