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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(EEF1A1-SHC1*)1Ravi
transgene insertion 1, Kodi S Ravichandran
MGI:2384188
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Tg(EEF1A1-SHC1*)1Ravi/?
Tg(Lck-cre)1Cwi/?
involves: 129 * C57BL/6 MGI:3851559
cn2
Tg(EEF1A1-SHC1*)1Ravi/0
Tg(Nes-cre)1Kln/0
involves: 129 * C57BL/6 * SJL MGI:3851591


Genotype
MGI:3851559
cn1
Allelic
Composition
Tg(EEF1A1-SHC1*)1Ravi/?
Tg(Lck-cre)1Cwi/?
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(EEF1A1-SHC1*)1Ravi mutation (1 available)
Tg(Lck-cre)1Cwi mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymus cellularity is only 10-30% of controls
• double-negative thymocyte numbers are similar to wild-type but the distribution of the sub-populations differs
• mice have a 83% DN3 stage thymocytes compared to 48% in normal mice, with a concomitant decrease in the DN4 stage thymocytes (46% in normal versus 8% in double-transgenic mice)
• these DN3 cells have less proliferation suggesting a partial block in development
• double-positive thymocyte numbers are decreased compared to wild-type while double-negative numbers are close to normal
• single-positive thymocyte numbers are decreased compared to controls

hematopoietic system
• thymus cellularity is only 10-30% of controls
• double-negative thymocyte numbers are similar to wild-type but the distribution of the sub-populations differs
• mice have a 83% DN3 stage thymocytes compared to 48% in normal mice, with a concomitant decrease in the DN4 stage thymocytes (46% in normal versus 8% in double-transgenic mice)
• these DN3 cells have less proliferation suggesting a partial block in development
• double-positive thymocyte numbers are decreased compared to wild-type while double-negative numbers are close to normal
• single-positive thymocyte numbers are decreased compared to controls

endocrine/exocrine glands
• thymus cellularity is only 10-30% of controls




Genotype
MGI:3851591
cn2
Allelic
Composition
Tg(EEF1A1-SHC1*)1Ravi/0
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(EEF1A1-SHC1*)1Ravi mutation (1 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• at birth and during early postnatal development, there is a slight body weight difference
• the biggest differences occur at 21 days of age
• later in life males have bigger body weight differences than females

nervous system
• apoptosis among neural progenitors is increased during embryonic brain development
• apoptosis is noted in the frontal cortex at E12.5 and in the pons at E10.5 and E12.5
• brain weight is less than controls from 2 days of age to 1 year in age
• the biggest differences occur at 21 days of age
• the stratium area is smaller at 2 days of age than controls and becomes even smaller at 21 days of age
• the entire thickness of the primary somatosensory cortex is reduced to less than 85% of controls
• layers II through IV are more dramatically affected (reduced by less 60% of controls in layer IV) than layers V-VI (reduced by 92% of controls)
• the cerebral cortex is thinner at 2 days of age than controls and becomes even thinner at 21 days of age
• at 2 days of age, the cerebral cortex is 58% smaller than controls which is more affected than other parts of the brain
• olfactory bulb is 82% of controls at 2 days of age
• the SVZ area is smaller at 2 days of age than controls and becomes even smaller at 21 days of age
• apoptosis among neural progenitors is increased during embryonic brain development
• proliferation of neural progenitors is not changed so presumably there are less progenitor cells in the developing brain

cellular
• apoptosis among neural progenitors is increased during embryonic brain development
• apoptosis is noted in the frontal cortex at E12.5 and in the pons at E10.5 and E12.5





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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory