Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgrtm1Hev mutation
(0 available);
any
Fgr mutation
(129 available)
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immune system
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• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice exhibit partially reduced hemorrhage compared to the thrombohemorrhagic vasculitis observed in wild-type mice
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Allelic
Composition |
Fgrtm1Hev/Fgrtm1Hev
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Genetic
Background |
involves: 129S7/SvEvBrd * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgrtm1Hev mutation
(0 available);
any
Fgr mutation
(129 available)
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immune system
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• stimulated natural killer (NK) cells produce more NKR-P1C-induced IFN-gamma than wild-type NK cells
• however, INF-gamma production by NK T cells is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgrtm1Hev mutation
(0 available);
any
Fgr mutation
(129 available)
Hcktm1Hev mutation
(0 available);
any
Hck mutation
(29 available)
Lyntm1Sor mutation
(2 available);
any
Lyn mutation
(64 available)
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immune system
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• neutrophil degranulation after adhesion is decreased compared to in wild-type mice
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• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice exhibit no hemorrhages and reduced fibrin deposition compared to the thrombohemorrhagic vasculitis observed in wild-type mice
• however, neutrophil migration is normal
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hematopoietic system
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• neutrophil degranulation after adhesion is decreased compared to in wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgrtm1Hev mutation
(0 available);
any
Fgr mutation
(129 available)
Hcktm1Hev mutation
(0 available);
any
Hck mutation
(29 available)
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immune system
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• reduced numbers of filopodia and increased lamellopodia related membrane structures
• abnormal F-actin organization
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• reduced tyrosine phosphorylation of adherent peritoneal exudate macrophage and in response to antibody crosslinking of alpha5 or beta1 integrin subunits
• impaired migration
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• of antibody labeled latex beads while antibody labeled sheep red blood cells undergo normal phagocytosis
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• impaired ability to resolve infection with Listeria monocytogenes
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cardiovascular system
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• angiogenic responses to Cxcl1 and Cxcl2 are disrupted
• neutrophile responses normal but they fail to release VEGF-A in response to Cxcl1 and Cxcl2
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hematopoietic system
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• reduced numbers of filopodia and increased lamellopodia related membrane structures
• abnormal F-actin organization
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• reduced tyrosine phosphorylation of adherent peritoneal exudate macrophage and in response to antibody crosslinking of alpha5 or beta1 integrin subunits
• impaired migration
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• of antibody labeled latex beads while antibody labeled sheep red blood cells undergo normal phagocytosis
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cellular
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• of antibody labeled latex beads while antibody labeled sheep red blood cells undergo normal phagocytosis
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Analysis Tools