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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fgf2tm1Bas
targeted mutation 1, Claudio Basilico
MGI:2384001
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fgf2tm1Bas/Fgf2tm1Bas involves: 129P2/OlaHsd * C57BL/6 MGI:3663305
hm2
 		Fgf2tm1Bas/Fgf2tm1Bas involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:3763719
cx3
 		Fgf1tm1Bas/Fgf1tm1Bas
Fgf2tm1Bas/Fgf2tm1Bas 		involves: 129P2/OlaHsd * C57BL/6 MGI:3663306


Genotype
MGI:3663305
hm1
Allelic
Composition		 Fgf2tm1Bas/Fgf2tm1Bas
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf2tm1Bas mutation (0 available); any Fgf2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal stratification in cerebral cortex ( J:47664 )
• layering in the cerebral cortex is less defined
• statistically reduced neuronal density in layers II-VI
thickened cerebral cortex ( J:47664 )
• layers V and VI are particularly thickened
abnormal frontal lobe morphology ( J:47664 )
• barrel structures in the barrel field of the S1 area are reduced

hematopoietic system
abnormal myeloblast morphology/development ( J:60597 )
• deficiency of myeloid precursors

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:104949 )
N
• homozygotes exhibit normal inner ear morphogenesis with no detectable abnormalities in adulthood
• in addition, homozygotes show no significant differences in hearing thresholds before and after noise-induced cochlear damage relative to wild-type littermates

homeostasis/metabolism
delayed wound healing ( J:47664 )
• wound healing is noticeably slowed but not impaired




Genotype
MGI:3763719
hm2
Allelic
Composition		 Fgf2tm1Bas/Fgf2tm1Bas
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf2tm1Bas mutation (0 available); any Fgf2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
loss of glutamate neurons ( J:126973 )
• fewer glutamate staining cells are found in the entire cerebral cortex compared to in wild-type mice with anterior cortical region exhibiting a more pronounced lack than the posterior region




Genotype
MGI:3663306
cx3
Allelic
Composition		 Fgf1tm1Bas/Fgf1tm1Bas
Fgf2tm1Bas/Fgf2tm1Bas
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf1tm1Bas mutation (0 available); any Fgf1 mutation (40 available)
Fgf2tm1Bas mutation (0 available); any Fgf2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neocortex morphology ( J:60597 )
• thickening of the neocortex and decreased neuronal cell density is seen which is similar to that in homozygous Fgf2tm1Bas mice

hematopoietic system
abnormal bone marrow cell morphology/development ( J:60597 )
• deficiency of myeloid precursors as seen in homozygous Fgf2tm1Bas mice

homeostasis/metabolism
delayed wound healing ( J:60597 )
• delayed wound healing similar to that in homozygous Fgf2tm1Bas mice is seen




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory