Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad52tm1Aps mutation
(1 available);
any
Rad52 mutation
(18 available)
|
|
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immune system
N |
• mice exhibit normal lymphocyte development and Ig class switching
|
reproductive system
N |
• mice exhibit normal reproductive system morphology and physiology
|
mortality/aging
|
• median survival is 33 weeks compared to 16 weeks for Atmtm1Awb homozygotes
|
neoplasm
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• mice develop thymic tumors
|
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• unlike in Atmtm1Awb homozygotes, mice rarely develop T cell lymphomas
|
immune system
growth/size/body
hematopoietic system
homeostasis/metabolism
endocrine/exocrine glands
|
• mice develop thymic tumors
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad52tm1Aps mutation
(1 available);
any
Rad52 mutation
(18 available)
Rad54ltm1Jhjh mutation
(0 available);
any
Rad54l mutation
(46 available)
|
|
|
mortality/aging
|
• following treatment with mitomycine C, mice exhibit increased lethality compared with similarly treated wild-type mice and Rad54ltm1Jhjh homozygotes
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hematopoietic system
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• following treatment with X-rays, mice exhibit severe hematopoietic depression compared with similarly treated wild-type mice and Rad54ltm1Jhjh homozygotes
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cellular
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• following mitomycine C treatment, mice exhibit a small reduction in the frequency of sister chromatid exchange compared with similarly treated wild-type mice
|
homeostasis/metabolism