Analysis Tools
mortality/aging
|
• die within 15 hours after birth
|
behavior/neurological
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• homozygotes are unsuccessful at feeding and lack the white 'milk spot'; unable to withdraw milk when fed by a pipette
|
digestive/alimentary system
|
• exhibit abnormalities of the keratohyalin granules in the epithelium of the tongue
|
homeostasis/metabolism
dehydration
(
J:56495
)
|
• exhibit a 5-10% loss of birth weight due to fluid evaporation
|
|
• homozygotes lose skin barrier function, as measured by penetration of external dyes and rapid loss of body fluids
|
craniofacial
|
• exhibit abnormalities of the keratohyalin granules in the epithelium of the tongue
|
integument
|
• homozygotes lose skin barrier function, as measured by penetration of external dyes and rapid loss of body fluids
|
|
• isolated cornified envelopes are rough, irregular and crumpled unlike the rigid, polygonal, plump, and smooth cornified envelopes of wild-type mice
• in the stratum corneum, intercellular lamellae are often discontinuous and highly variable in thickness; the lamellae often show a wavy, disorganized pattern and large internal aggregates of disorganized lamellae are evident
|
parakeratosis
(
J:56495
)
|
• stratum corneum cells fail to flatten and discard their cytoplasmic organelles
|
|
• the granular layer exhibits alterations in its characteristic, darkly stained keratohyalin granules and the granular cells fail to flatten and discard their cytoplasmic organelles
• in the late stages of terminal differentiation, keratohyalin granules in the granular layers are reduced in numbers and are smaller
|
growth/size/body
|
• exhibit abnormalities of the keratohyalin granules in the epithelium of the tongue
|
