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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nrp2tm1.2Mom
targeted mutation 1.2, Peter Mombaerts
MGI:2183904
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nrp2tm1.2Mom/Nrp2tm1.2Mom involves: 129P2/OlaHsd * C57BL/6 * FVB/NJ MGI:4843917
hm2
Nrp2tm1.2Mom/Nrp2tm1.2Mom involves: 129P2/OlaHsd * C57BL/6 * SJL/J MGI:3618513
ht3
Nrp2tm1.2Mom/Nrp2+ involves: 129P2/OlaHsd * C57BL/6 * FVB/NJ MGI:4843918
cx4
Gucy2dtm1Mom/Gucy2dtm1Mom
Nrp2tm1.2Mom/Nrp2tm1.2Mom
involves: 129P2/OlaHsd * C57BL/6J MGI:3760743
cx5
Nrp2tm1.2Mom/Nrp2tm1.2Mom
Vmn1r49tm1Mom/Vmn1r49tm1Mom
involves: 129P2/OlaHsd * C57BL/6J MGI:3760744


Genotype
MGI:4843917
hm1
Allelic
Composition
Nrp2tm1.2Mom/Nrp2tm1.2Mom
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp2tm1.2Mom mutation (1 available); any Nrp2 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mutants treated with KA to induce seizures die within a week (J:166116)
• all mutants treated with KA to induce seizures die within a week (J:166116)
• some mice die in spontaneous status epilepticus between P7 and P21 (J:166116)
• some mice die in spontaneous status epilepticus between P7 and P21 (J:166116)

behavior/neurological
• all mutants treated with kainic acid (KA) to induce seizures die within a week (J:166116)
• all mutants treated with kainic acid (KA) to induce seizures die within a week (J:166116)
• 12 of 51 mice exhibit random handling-induced seizures (J:166116)
• 12 of 51 mice exhibit random handling-induced seizures (J:166116)
• 12 of 51 mice exhibit random handling-induced seizures (J:166116)
• 12 of 51 mice exhibit random handling-induced seizures (J:166116)

muscle
• 12 of 51 mice exhibit random handling-induced seizures (J:166116)
• 12 of 51 mice exhibit random handling-induced seizures (J:166116)

nervous system
• all mutants treated with kainic acid (KA) to induce seizures die within a week (J:166116)
• all mutants treated with kainic acid (KA) to induce seizures die within a week (J:166116)
• 12 of 51 mice exhibit random handling-induced seizures (J:166116)
• 12 of 51 mice exhibit random handling-induced seizures (J:166116)
• 12 of 51 mice exhibit random handling-induced seizures (J:166116)
• 12 of 51 mice exhibit random handling-induced seizures (J:166116)
• mutants exhibit selective loss of GABAergic cells in the hippocampus (J:166116)
• Parv+ and NPY+ neurons are reduced in the hippocampus (J:166116)
• mutants exhibit selective loss of GABAergic cells in the hippocampus (J:166116)
• Parv+ and NPY+ neurons are reduced in the hippocampus (J:166116)

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:166116




Genotype
MGI:3618513
hm2
Allelic
Composition
Nrp2tm1.2Mom/Nrp2tm1.2Mom
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp2tm1.2Mom mutation (1 available); any Nrp2 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygous mutant pups are born alive at a reduced frequency (10.9% vs expected 25%); however, no increased mortality is noted in juvenile or adult mice (J:76686)
• homozygous mutant pups are born alive at a reduced frequency (10.9% vs expected 25%); however, no increased mortality is noted in juvenile or adult mice (J:76686)

nervous system
• homozygotes display aberrant axonal innervation of the main olfactory bulb and accessory olfactory bulb by olfactory sensory neurons and vomeronasal sensory neurons, respectively (J:76686)
• homozygotes display aberrant axonal innervation of the main olfactory bulb and accessory olfactory bulb by olfactory sensory neurons and vomeronasal sensory neurons, respectively (J:76686)
• in the vomeronasal system, homozygotes exhibit axonal defasciculation within the vomeronasal nerve (J:76686)
• in the vomeronasal system, homozygotes exhibit axonal defasciculation within the vomeronasal nerve (J:76686)
• 63.6% of homozygotes exhibit hydrocephalus (not observed in heterozygotes) (J:76686)
• 63.6% of homozygotes exhibit hydrocephalus (not observed in heterozygotes) (J:76686)
• in the vomeronasal system, some apical vomeronasal sensory neuron axons are misrouted and innervate glomeruli in an ectopic domain of the accessory olfactory bulb (J:76686)
• in the vomeronasal system, some apical vomeronasal sensory neuron axons are misrouted and innervate glomeruli in an ectopic domain of the accessory olfactory bulb (J:76686)
• homozygotes display marked and distinct abnormalities on target innervation within the olfactory bulb (J:76686)
• in the main olfactory system, axons of mutant olfactory sensory neurons penetrate into the deeper layers of the main olfactory bulb, overshooting their glomerular target and extending into the external plexiform layer (J:76686)
• homozygotes display marked and distinct abnormalities on target innervation within the olfactory bulb (J:76686)
• in the main olfactory system, axons of mutant olfactory sensory neurons penetrate into the deeper layers of the main olfactory bulb, overshooting their glomerular target and extending into the external plexiform layer (J:76686)
• some apical vomeronasal sensory neuron axons are misrouted and innervate glomeruli in an ectopic domain of the accessory olfactory bulb (J:76686)
• some apical vomeronasal sensory neuron axons are misrouted and innervate glomeruli in an ectopic domain of the accessory olfactory bulb (J:76686)

growth/size/body
• in the vomeronasal system, homozygotes exhibit axonal defasciculation within the vomeronasal nerve (J:76686)
• in the vomeronasal system, homozygotes exhibit axonal defasciculation within the vomeronasal nerve (J:76686)
• at P2-P3, mutant pups display a striking reduction of overall body size, resulting in ~50% of normal size at 3 weeks of age (J:76686)
• however, mutant mice catch up with their wild-type littermates at weaning, and exhibit a normal body size after 6-8 weeks (J:76686)
• at P2-P3, mutant pups display a striking reduction of overall body size, resulting in ~50% of normal size at 3 weeks of age (J:76686)
• however, mutant mice catch up with their wild-type littermates at weaning, and exhibit a normal body size after 6-8 weeks (J:76686)

reproductive system
• homozygotes often are not able to reproduce (J:76686)
• homozygotes often are not able to reproduce (J:76686)

respiratory system
• in the vomeronasal system, homozygotes exhibit axonal defasciculation within the vomeronasal nerve (J:76686)
• in the vomeronasal system, homozygotes exhibit axonal defasciculation within the vomeronasal nerve (J:76686)

craniofacial
• in the vomeronasal system, homozygotes exhibit axonal defasciculation within the vomeronasal nerve (J:76686)
• in the vomeronasal system, homozygotes exhibit axonal defasciculation within the vomeronasal nerve (J:76686)

cellular
• homozygotes display aberrant axonal innervation of the main olfactory bulb and accessory olfactory bulb by olfactory sensory neurons and vomeronasal sensory neurons, respectively (J:76686)
• homozygotes display aberrant axonal innervation of the main olfactory bulb and accessory olfactory bulb by olfactory sensory neurons and vomeronasal sensory neurons, respectively (J:76686)




Genotype
MGI:4843918
ht3
Allelic
Composition
Nrp2tm1.2Mom/Nrp2+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp2tm1.2Mom mutation (1 available); any Nrp2 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• 7 of 9 mutants treated with kainic acid (KA) to induce seizures, develop at least two spontaneous seizures that qualify as epilepsy (J:166116)
• mutants treated with KA to induce seizures exhibit a shorter latency to onset of seizures (J:166116)
• mutants treated with pentylenetretrazol (PTZ) to induce seizures exhibit a significantly shorter latency to onset of seizures than controls but exhibit a similar number of acute seizures as controls (J:166116)
• 7 of 9 mutants treated with kainic acid (KA) to induce seizures, develop at least two spontaneous seizures that qualify as epilepsy (J:166116)
• mutants treated with KA to induce seizures exhibit a shorter latency to onset of seizures (J:166116)
• mutants treated with pentylenetretrazol (PTZ) to induce seizures exhibit a significantly shorter latency to onset of seizures than controls but exhibit a similar number of acute seizures as controls (J:166116)
• 14 of 273 mice exhibit random handling-induced seizures (J:166116)
• 14 of 273 mice exhibit random handling-induced seizures (J:166116)
• 14 of 273 mice exhibit random handling-induced seizures (J:166116)
• 14 of 273 mice exhibit random handling-induced seizures (J:166116)

muscle
• 14 of 273 mice exhibit random handling-induced seizures (J:166116)
• 14 of 273 mice exhibit random handling-induced seizures (J:166116)

nervous system
• moderate decrease in dendritic branching and total dendritic length of CA1 pyramidal cells (J:166116)
• moderate decrease in dendritic branching and total dendritic length of CA1 pyramidal cells (J:166116)
• N type and D type spines are increased 11% compared to CA1 neurons from wild-type (J:166116)
• N type and D type spines are increased 11% compared to CA1 neurons from wild-type (J:166116)
• mutants exhibit enhanced excitability in the hippocampus as indicated by an increase in population spike (PS) amplitude (J:166116)
• mutants exhibit enhanced excitability in the hippocampus as indicated by an increase in population spike (PS) amplitude (J:166116)
• 7 of 9 mutants treated with kainic acid (KA) to induce seizures, develop at least two spontaneous seizures that qualify as epilepsy (J:166116)
• mutants treated with KA to induce seizures exhibit a shorter latency to onset of seizures (J:166116)
• mutants treated with pentylenetretrazol (PTZ) to induce seizures exhibit a significantly shorter latency to onset of seizures than controls but exhibit a similar number of acute seizures as controls (J:166116)
• 7 of 9 mutants treated with kainic acid (KA) to induce seizures, develop at least two spontaneous seizures that qualify as epilepsy (J:166116)
• mutants treated with KA to induce seizures exhibit a shorter latency to onset of seizures (J:166116)
• mutants treated with pentylenetretrazol (PTZ) to induce seizures exhibit a significantly shorter latency to onset of seizures than controls but exhibit a similar number of acute seizures as controls (J:166116)
• 14 of 273 mice exhibit random handling-induced seizures (J:166116)
• 14 of 273 mice exhibit random handling-induced seizures (J:166116)
• 14 of 273 mice exhibit random handling-induced seizures (J:166116)
• 14 of 273 mice exhibit random handling-induced seizures (J:166116)
• short-term plasticity is altered as indicated by a decrease in the facilitation of the secondary population spike (PS) elicited during the 7 Hz stimulation train (J:166116)
• short-term plasticity is altered as indicated by a decrease in the facilitation of the secondary population spike (PS) elicited during the 7 Hz stimulation train (J:166116)




Genotype
MGI:3760743
cx4
Allelic
Composition
Gucy2dtm1Mom/Gucy2dtm1Mom
Nrp2tm1.2Mom/Nrp2tm1.2Mom
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gucy2dtm1Mom mutation (1 available); any Gucy2d mutation (2 available)
Nrp2tm1.2Mom mutation (1 available); any Nrp2 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• guanylate cyclase- D (GC-D) positive glomeruli fan out more than in wild-type mice and glomeruli form at inappropriate locations (J:125485)
• many GC-D+ glomeruli scatter ectopically across the main olfactory bulb up to the rostral tip (J:125485)
• fewer GC-D+ glomeruli are found in the necklace compared to in wild-type mice (J:125485)
• the number of GC-D+ glomeruli is increased compared to in wild-type mice (J:125485)
• Npr2+ axons erroneously project into the posterior accessory olfactory bulb (J:125485)
• guanylate cyclase- D (GC-D) positive glomeruli fan out more than in wild-type mice and glomeruli form at inappropriate locations (J:125485)
• many GC-D+ glomeruli scatter ectopically across the main olfactory bulb up to the rostral tip (J:125485)
• fewer GC-D+ glomeruli are found in the necklace compared to in wild-type mice (J:125485)
• the number of GC-D+ glomeruli is increased compared to in wild-type mice (J:125485)
• Npr2+ axons erroneously project into the posterior accessory olfactory bulb (J:125485)




Genotype
MGI:3760744
cx5
Allelic
Composition
Nrp2tm1.2Mom/Nrp2tm1.2Mom
Vmn1r49tm1Mom/Vmn1r49tm1Mom
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp2tm1.2Mom mutation (1 available); any Nrp2 mutation (30 available)
Vmn1r49tm1Mom mutation (1 available); any Vmn1r49 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• axonal projections exhibit defasciculation across the medial surface of the main olfactory bulb (J:125485)
• axonal projections exhibit defasciculation across the medial surface of the main olfactory bulb (J:125485)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory