About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ncoa2tm1.1Ipc
targeted mutation 1.1, I Pierre Chambon
MGI:2183799
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ncoa2tm1.1Ipc/Ncoa2tm1.1Ipc
Pgrtm2(cre)Lyd/Pgr+
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ MGI:3716551
cn2
Ncoa1tm1Bwo/Ncoa1tm1Bwo
Ncoa2tm1.1Ipc/Ncoa2tm1.1Ipc
Pgrtm2(cre)Lyd/Pgr+
involves: 129/Sv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ MGI:3716555


Genotype
MGI:3716551
cn1
Allelic
Composition
Ncoa2tm1.1Ipc/Ncoa2tm1.1Ipc
Pgrtm2(cre)Lyd/Pgr+
Genetic
Background
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncoa2tm1.1Ipc mutation (0 available); any Ncoa2 mutation (56 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• uterus displays only partial decidual response to the deciduogenic stimulus estradiol + progesterone

reproductive system
N
• gonadotropin-treated ovaries ovulate comparably to wild-type, showing similar oocyte production
• epithelial proliferation in estradiol-treated ovarectomized uteri from mutants is similar to wild-type
• uterus displays only partial decidual response to the deciduogenic stimulus estradiol + progesterone
• implantation sites are absent at 5.5 days post-coitum
• females are infertile, despite normal mating behavior and presence of copulatory plugs; no litters were produced during six months of observation

endocrine/exocrine glands
• after a 3-week estradiol + progesterone treatment regime, full ductal side-branching and alveogenesis does not occur in mutant mammary glands in contrast to wild-type

integument
• after a 3-week estradiol + progesterone treatment regime, full ductal side-branching and alveogenesis does not occur in mutant mammary glands in contrast to wild-type




Genotype
MGI:3716555
cn2
Allelic
Composition
Ncoa1tm1Bwo/Ncoa1tm1Bwo
Ncoa2tm1.1Ipc/Ncoa2tm1.1Ipc
Pgrtm2(cre)Lyd/Pgr+
Genetic
Background
involves: 129/Sv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncoa1tm1Bwo mutation (0 available); any Ncoa1 mutation (150 available)
Ncoa2tm1.1Ipc mutation (0 available); any Ncoa2 mutation (56 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• uterus fails to display any decidual response upon stimulation

embryo
• uterus fails to display any decidual response upon stimulation





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/14/2020
MGI 6.14
The Jackson Laboratory