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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(UcpDta)1Kz
transgene insertion 1, Leslie P Kozak
MGI:2183746
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(APOB)11Rub/0
Tg(UcpDta)1Kz/0
involves: C57BL/6J * FVB/N MGI:2385750
tg2
Tg(UcpDta)1Kz/0 FVB/N-Tg(UcpDta)1Kz/J MGI:4429478
tg3
Tg(UcpDta)1Kz/? involves: FVB/N MGI:2385751


Genotype
MGI:2385750
cx1
Allelic
Composition
Tg(APOB)11Rub/0
Tg(UcpDta)1Kz/0
Genetic
Background
involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APOB)11Rub mutation (0 available)
Tg(UcpDta)1Kz mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• on a high-fat, Western diet by 10 weeks of age, males are significantly heavier than Tg(APOB)11Rub and wild-type controls

homeostasis/metabolism
• males on a Western diet exhibit increased fasting plasma insulin levels
• however, fasting plasma glucose and free fatty acid levels do not vary from controls
• males, but not females, are insulin resistant; males are impaired in their ability to clear exogenously administered glucose
• males display a human-like dyslipidemia
• males exhibit increased synthesis and secretion of very low density lipoprotein (VLDL) triglycerides
• males exhibit increased apolipoprotein B (apoB) secretion rates
• HDL cholesterol is significantly reduced relative to Tg(APOB)11Rub mice
• males on a Western diet exhibit increased fasting plasma total cholesterol concentrations
• LDL cholesterol is increased relative to Tg(APOB)11Rub mice
• males on a Western diet exhibit increased fasting plasma triglyceride concentrations
• IDL/LDL triglyceride levels are increased

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:78211




Genotype
MGI:4429478
tg2
Allelic
Composition
Tg(UcpDta)1Kz/0
Genetic
Background
FVB/N-Tg(UcpDta)1Kz/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(UcpDta)1Kz mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice exhibit impaired glucose tolerance compared with wild-type mice
• however, inhibition of fatty acid oxidation improves glucose tolerance




Genotype
MGI:2385751
tg3
Allelic
Composition
Tg(UcpDta)1Kz/?
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(UcpDta)1Kz mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• by 27 weeks, mice were nearly double the weight of controls
• evident at 16 days of age and progressive

adipose tissue
• lacked brown adipose tissue
• by 19 weeks, mice had greater than 50% body fat

homeostasis/metabolism
N
• normal corticosterone levels
• hypertriglyceridemia
• plasma triglyceride is dramatically increased over that of non-transgenic controls, and this can be reduced by hepatic overexpression of lipin 1

behavior/neurological
• beginning at 5-7 weeks

nervous system
N
• histologically normal hypothalamus

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:78211





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory