Mouse Genome Informatics
cx1
    Tg(APOB)11Rub/0
Tg(UcpDta)1Kz/0

involves: C57BL/6J * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size
• on a high-fat, Western diet by 10 weeks of age, males are significantly heavier than Tg(APOB)11Rub and wild-type controls

homeostasis/metabolism
• males on a Western diet exhibit increased fasting plasma insulin levels
• however, fasting plasma glucose and free fatty acid levels do not vary from controls
• males, but not females, are insulin resistant; males are impaired in their ability to clear exogenously administered glucose
• males display a human-like dyslipidemia
• males exhibit increased synthesis and secretion of very low density lipoprotein (VLDL) triglycerides
• males exhibit increased apolipoprotein B (apoB) secretion rates
• HDL cholesterol is significantly reduced relative to Tg(APOB)11Rub mice
• males on a Western diet exhibit increased fasting plasma total cholesterol concentrations
• LDL cholesterol is increased relative to Tg(APOB)11Rub mice
• males on a Western diet exhibit increased fasting plasma triglyceride concentrations
• IDL/LDL triglyceride levels are increased

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:78211


Mouse Genome Informatics
tg2
    Tg(UcpDta)1Kz/0
FVB/N-Tg(UcpDta)1Kz/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• mice exhibit impaired glucose tolerance compared with wild-type mice
• however, inhibition of fatty acid oxidation improves glucose tolerance


Mouse Genome Informatics
tg3
    Tg(UcpDta)1Kz/?
involves: FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size
• by 19 weeks, mice had greater than 50% body fat
• by 27 weeks, mice were nearly double the weight of controls
• evident at 16 days of age and progressive

adipose tissue
• lacked brown adipose tissue
• by 19 weeks, mice had greater than 50% body fat

homeostasis/metabolism
N
• normal corticosterone levels (J:78211)
• hypertriglyceridemia
• plasma triglyceride is dramatically increased over that of non-transgenic controls, and this can be reduced by hepatic overexpression of lipin 1

behavior/neurological
• beginning at 5-7 weeks

nervous system
N
• histologically normal hypothalamus (J:78211)

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:78211