Analysis Tools
behavior/neurological
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• treatment of fasted female mice with CCK-8 inhibited food intake in wild-type mice but not in mutants between 30 and 180 minutes
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Allele Symbol Allele Name Allele ID |
Mc4rtm1Dhu targeted mutation 1, Dennis Huszar MGI:2183586 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• treatment of fasted female mice with CCK-8 inhibited food intake in wild-type mice but not in mutants between 30 and 180 minutes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• slower metabolic response to higher fat in the diet as measured by VO2
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• increased body length at 19 weeks, disregarding tails
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• weight normal until after 4 weeks of age
(J:38224)
• by 5 weeks most mice were heavier than controls
(J:38224)
• after 7 weeks, all mice were heavier than controls, by 50% for males and 2 fold for females
(J:38224)
• conventionally housed mice are heavier than controls and heavier than mice with free access to a running wheel
(J:94617)
• rapidly gain weight when no longer able to exercise but weight gain is reversed somewhat if opportunity to exercise is restored
(J:94617)
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• the stress of isolation inhibits feeding
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• hyperphagia
(J:38224)
• food consumption in females increased by 46%
(J:38224)
• food consumption normal when given free access to a running wheel but become hyperphagic when access to running wheels is removed
(J:94617)
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• tended to exercise somewhat less than controls when given access to a running wheel
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• more active in daylight
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• slower metabolic response to higher fat in the diet as measured by VO2
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• levels elevated 1.5X in males and 4.5X in females at 4-8 weeks of age
• levels elevated 2.5X in males and 6.5X in females at 17-23 weeks of age
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• in males only by 10-14 weeks of age
• at 17-23 weeks of age male blood glucose levels are 2X normal
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• hyperinsulinemia in both males and females
• levels increased 5 fold in males and 9 fold in females at 4-8 weeks of age
• at 17-23 weeks of age levels increased to 14X normal in males and to 60X normal in females
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• conventionally housed animals reproduced poorly, far fewer litters
• reproduced almost as well as controls when able to exercise
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• reduced number of osteoclasts
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• exhibit high bone mass at 6 months of age
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• reduced number of osteoclasts
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• reduced number of osteoclasts
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| obesity | DOID:9970 |
OMIM:601665 |
J:38224 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• compared with either single homozygote
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• compared with either single homozygote
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 26 weeks, female mice are 27% heavier than Mc4rtm1Dhu homozygotes
• at 26 weeks, male mice are 13% heavier than Mc4rtm1Dhu homozygotes
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| obesity | DOID:9970 |
OMIM:601665 |
J:64365 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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