Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm4Sho mutation
(0 available);
any
Gata1 mutation
(44 available)
Gata2tm2Sho mutation
(0 available);
any
Gata2 mutation
(26 available)
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mortality/aging
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• mice begin to die at late E10.5
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hematopoietic system
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N |
• despite disruptions in erythropoiesis and megakaryopoiesis, granulocytes and macrophages form normally
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• erythropoeisis is arrested in maturation at a precursor stage
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• no megakaryocyte colonies can be generated from yolk sac cells unlike when wild-type cells are cultured
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Allelic
Composition |
Gata1tm4Sho/Y
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Genetic
Background |
involves: 129S6/SvEvTac * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm4Sho mutation
(0 available);
any
Gata1 mutation
(44 available)
|
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mortality/aging
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• remaining mice die shortly after birth
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hematopoietic system
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• late stage maturation of megakaryocytes generated in culture from yolk sac cells is disrupted with fewer platelet granules forming and disorganization in platelet demarcations unlike in wild-type cells
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• yolk sac erythrocytes exhibit arrested maturation unlike in wild-type mice
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• slightly fewer megakaryocyte colonies can be generated from yolk sac cells compared to when wild-type cells are cultured
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cellular
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• late stage maturation of megakaryocytes generated in culture from yolk sac cells is disrupted with fewer platelet granules forming and disorganization in platelet demarcations unlike in wild-type cells
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Analysis Tools