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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Plcb4tm1Dwu
targeted mutation 1, Dianqing Wu
MGI:2183374
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Plcb4tm1Dwu/Plcb4tm1Dwu involves: 129S1/Sv MGI:3715029


Genotype
MGI:3715029
hm1
Allelic
Composition
Plcb4tm1Dwu/Plcb4tm1Dwu
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcb4tm1Dwu mutation (1 available); any Plcb4 mutation (106 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Retinal morphology of Plcb4tm1Dwu/Plcb4tm1Dwu mice

vision/eye
• 4-fold reduction in the maximal amplitude of the rod a- and b-wave components
• however, recording from single rod photoreceptors does not show any differences and retinas show no apparent histological abnormalities
• in a shuttle box avoidance learning test in conjunction with either light or sound stimulation, mutants are unable to associate light with foot-shock but are able to associate sound with foot-shock, indicating impaired visual processing

behavior/neurological
• when placed on a thin rod, mutants cannot coordinate the placement of the hind feet
• duration of balancing on a rotorod is shorter
• however, mutants exhibit normal grasping responses
• mutants cannot walk for an extended time on a straight path
• mutants exhibit signs of ataxia that become obvious 2-3 weeks after birth, including general uncoordinated movements, body swaying while moving, ataxic gait and intention tremors

nervous system
• a significantly higher number of Purkinje cells remain multiply-innervated, particularly in the rostral portion of the cerebellar vermis, indicating that elimination of multiple climbing fiber innervation is impaired
• however, cerebellar histology, parallel fiber synapse formation and basic electrophysiology appear normal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory