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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rbp3tm1Gil
targeted mutation 1, Gregory I Liou
MGI:2183368
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rbp3tm1Gil/Rbp3tm1Gil involves: 129P2/OlaHsd * C57BL/6J MGI:3039689


Genotype
MGI:3039689
hm1
Allelic
Composition
Rbp3tm1Gil/Rbp3tm1Gil
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbp3tm1Gil mutation (1 available); any Rbp3 mutation (90 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• outer segments are poorly oriented and only about 60% of normal length
• outer segments are short with loss or disruption of many membranous disks
• photoreceptor degeneration is seen in animals raised in darkness (J:57704)
• loss of photoreceptors (J:77624)
• thinning of the outer nuclear layer to a thickness of 6-8 cells rather than 10-11 at age 11 days
• by 1 month of age, outer nuclear layer has become thinner than at 11 days of age
• electroretinogram response in 1 month old rats is reduced in amplitude
• a-wave amplitude is half that of normal controls

nervous system
• outer segments are poorly oriented and only about 60% of normal length
• outer segments are short with loss or disruption of many membranous disks
• photoreceptor degeneration is seen in animals raised in darkness (J:57704)
• loss of photoreceptors (J:77624)





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory