All Phenotypes Thrb<tm2Few> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Thrb^tm2Few
targeted mutation 2, Frederic E Wondisford
MGI:2183367

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thrb^tm2Few/Thrb^tm2Few	involves: 129X1/SvJ * C57BL/6	MGI:3588063
ht2	Thrb^tm2Few/Thrb⁺	involves: 129X1/SvJ * C57BL/6	MGI:3588064

Allelic Composition	Thrb^tm2Few/Thrb^tm2Few
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thrb^tm2Few mutation (0 available); any Thrb mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal spatial learning ( J:77623 )

• learning deficit identified in a Morris water maze tes

nervous system

abnormal cerebellar Purkinje cell layer ( J:77623 )

• thin

abnormal Purkinje cell morphology ( J:77623 )

• reduced branching

decreased Purkinje cell number ( J:77623 )

thin cerebellar molecular layer ( J:77623 )

small cerebellum ( J:77623 )

• changes similar to those seen in congenital hypothyroidism

homeostasis/metabolism

increased circulating thyroid-stimulating hormone level ( J:77623 )

• 3 fold elevation over levels seen in Thrb^tm1Df homozygotes

increased thyroxine level ( J:77623 )

increased triiodothyronine level ( J:77623 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
thyroid hormone resistance syndrome		DOID:11633	OMIM:188570 OMIM:274300	J:77623

Allelic Composition	Thrb^tm2Few/Thrb⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6