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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ptentm1.1Mro
targeted mutation 1.1, Silvia Marino
MGI:2183285
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ptentm1.1Mro/Ptentm1.1Mro involves: BALB/cJ MGI:3805881
ht2
Ptentm1.1Mro/Pten+ Not Specified MGI:5812675
cx3
Ptentm1.1Mro/Pten+
Sdhbtm1.2Ics/Sdhb+
involves: 129S2/SvPas * BALB/c * C57BL/6 MGI:5812674


Genotype
MGI:3805881
hm1
Allelic
Composition
Ptentm1.1Mro/Ptentm1.1Mro
Genetic
Background
involves: BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1.1Mro mutation (0 available); any Pten mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• authors state that mice exhibit a phenotype that mimicked the phenotype observed in other Pten knockout mice

embryo
• authors state that mice exhibit a phenotype that mimicked the phenotype observed in other Pten knockout mice

neoplasm
• authors state that mice exhibit a phenotype that mimicked the phenotype observed in other Pten knockout mice




Genotype
MGI:5812675
ht2
Allelic
Composition
Ptentm1.1Mro/Pten+
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1.1Mro mutation (0 available); any Pten mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• at 10 months of age, 73% of mice develop a pheochromocytoma
• tumors do not show accumulation of succinate

neoplasm
• at 10 months of age, 73% of mice develop a pheochromocytoma
• tumors do not show accumulation of succinate
• lung micro-metastasis are seen in 64% of mice




Genotype
MGI:5812674
cx3
Allelic
Composition
Ptentm1.1Mro/Pten+
Sdhbtm1.2Ics/Sdhb+
Genetic
Background
involves: 129S2/SvPas * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1.1Mro mutation (0 available); any Pten mutation (81 available)
Sdhbtm1.2Ics mutation (0 available); any Sdhb mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• at 10 months of age, 80% of mice develop a pheochromocytoma

neoplasm
• at 10 months of age, 80% of mice develop a pheochromocytoma
• lung micro-metastasis are seen in 73% of mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory