All Phenotypes Pten<tm1Mro> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pten^tm1Mro
targeted mutation 1, Silvia Marino
MGI:2183284

Summary

16 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Braf^tm1Mmcm/Braf⁺ Pten^tm1Mro/Pten^tm1Mro Tg(Tyr-cre/ERT2)1Lru/0	B6.Cg-Braf^tm1Mmcm Tg(Tyr-cre/ERT2)1Lru Pten^tm1Mro	MGI:5447169
cn2	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor Pten^tm1Mro/Pten^tm1Mro Rb1^tm2Brn/Rb1^tm2Brn Trp53^tm1Brn/Trp53^tm1Brn	involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:5563247
cn3	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor Pten^tm1Mro/Pten^tm1Mro Rb1^tm2Brn/Rb1^tm2Brn	involves: 129 * 129S4/SvJaeSor * C57BL/6 * FVB	MGI:5563246
cn4	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor Pten^tm1Mro/Pten^tm1Mro Slc1a3^{tm1(cre/ERT2)Mgoe}/Slc1a3⁺ Trp53^tm1Brn/Trp53^tm1Brn	involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor	MGI:5790976
cn5	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor Pten^tm1Mro/Pten^tm1Mro Trp53^tm1Brn/Trp53^tm1Brn	involves: 129P2/OlaHsd * 129S4/SvJaeSor	MGI:5790977
cn6	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor Pten^tm1Mro/Pten^tm1Mro Trp53^tm1Brn/Trp53^tm1Brn	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB	MGI:5563238
cn7	Pten^tm1Mro/Pten^tm1Mro Tg(KRT14-cre)8Brn/0 Trp53^tm1Brn/Trp53^tm1Brn	involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * DBA/2J * FVB/N	MGI:3842835
cn8	Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺ Pten^tm1Mro/Pten⁺ Tg(Pbsn-cre)4Prb/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N	MGI:5427498
cn9	Pten^tm1Mro/Pten⁺ Tg(KLK3-cre)D4Trp/0	involves: 129P2/OlaHsd * FVB	MGI:3761927
cn10	Pten^tm1Mro/Pten^tm1Mro Tg(KLK3-cre)D4Trp/0	involves: 129P2/OlaHsd * FVB	MGI:3761928
cn11	Pten^tm1Mro/Pten^tm1Mro Sdhb^tm1.1Ics/Sdhb^tm1.2Ics Tg(KLK3-cre)D4Trp/0	involves: 129S2/SvPas * BALB/c * C57BL/6 * FVB	MGI:5812678
cn12	Pten^tm1Mro/Pten^tm1Mro Sdhb^tm1.1Ics/Sdhb⁺ Tg(KLK3-cre)D4Trp/0	involves: 129S2/SvPas * FVB	MGI:5812676
cn13	Pten^tm1Mro/Pten⁺ Sdhb^tm1.1Ics/Sdhb⁺ Tg(KLK3-cre)D4Trp/0	involves: 129S2/SvPas * FVB	MGI:5812679
cn14	Pten^tm1Mro/Pten⁺ Tg(Pbsn-cre)4Prb/0	involves: C57BL/6 * DBA/2	MGI:5427499
cn15	Pten^tm1Mro/Pten^tm1Mro Tg(Pcp2-cre)756Mro/0	involves: FVB/N	MGI:3805877
cn16	Pten^tm1Mro/Pten^tm1Mro Tg(En2-cre)22Alj/0	Not Specified	MGI:3805876

Allelic Composition	Braf^tm1Mmcm/Braf⁺ Pten^tm1Mro/Pten^tm1Mro Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background	B6.Cg-Braf^tm1Mmcm Tg(Tyr-cre/ERT2)1Lru Pten^tm1Mro

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braf^tm1Mmcm mutation (3 available); any Braf mutation (58 available)
Pten^tm1Mro mutation (1 available); any Pten mutation (81 available)
Tg(Tyr-cre/ERT2)1Lru mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:188523 )

• tamoxifen-treated mice must be euthanized between 40 and 70 days due to tumor load or ulceration

decreased tumor-free survival time ( J:188523 )

• in tamoxifen treated mice

neoplasm

increased cutaneous melanoma incidence ( J:188523 )

• tamoxifen-treated mice develop multiple heavily pigmented papules with an average latency of 18 days

• tamoxifen-treated mice exhibit metastasis in draining lymph nodes as early as 4 weeks after tumor induction

• however, no visceral metastasis is observed

• however, treatment with PLX4720 decreases tumor outgrowth

• in the absences of tamoxifen, most mice develop spontaneous melanomas due to leaky cre expression

integument

spontaneous skin ulceration ( J:188523 )

• in tamoxifen-treated mice

increased cutaneous melanoma incidence ( J:188523 )

• tamoxifen-treated mice develop multiple heavily pigmented papules with an average latency of 18 days

• tamoxifen-treated mice exhibit metastasis in draining lymph nodes as early as 4 weeks after tumor induction

• however, no visceral metastasis is observed

• however, treatment with PLX4720 decreases tumor outgrowth

• in the absences of tamoxifen, most mice develop spontaneous melanomas due to leaky cre expression

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor Pten^tm1Mro/Pten^tm1Mro Rb1^tm2Brn/Rb1^tm2Brn Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (942 available)
Pten^tm1Mro mutation (1 available); any Pten mutation (81 available)
Rb1^tm2Brn mutation (3 available); any Rb1 mutation (106 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased nervous system tumor incidence ( J:204385 )

• mice injected with an adenovirus expressing cre (adeno-cre) into the lateral ventricle predominantly develop poorly differentiated, well-circumscribed neoplasms with similarity to supratentorial primitive neuroectodermal tumors (sPNET)

• expression profiles of tumors resemble human atypical teratoid/rhabdoid tumor

nervous system

increased nervous system tumor incidence ( J:204385 )

• expression profiles of tumors resemble human atypical teratoid/rhabdoid tumor

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor Pten^tm1Mro/Pten^tm1Mro Rb1^tm2Brn/Rb1^tm2Brn
Genetic Background	involves: 129 * 129S4/SvJaeSor * C57BL/6 * FVB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:204385 )

N	• mice injected with an adenovirus expressing cre (adeno-cre) into the lateral ventricle do not develop tumors after up to 440 days

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor Pten^tm1Mro/Pten^tm1Mro Slc1a3^{tm1(cre/ERT2)Mgoe}/Slc1a3⁺ Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (942 available)
Pten^tm1Mro mutation (1 available); any Pten mutation (81 available)
Slc1a3^{tm1(cre/ERT2)Mgoe} mutation (0 available); any Slc1a3 mutation (66 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased glioma incidence ( J:229481 )

• 3 of 16 mice injected with endoxifen develop glial tumors with lesions of different sizes and varying extents of infiltration

• small neoplastic lesions in endoxifen-induced mice arise from beneath the SVZ and extend into the striatum and dorsally into the corpus callosum

• larger tumors of endoxifen-induced mice show expansion into and a diffuse infiltration of the entire caudate nucleus

• some tumors contain areas of necrosis and occasional microvascular proliferations similar to those in malignant gliomas

increased astrocytoma incidence ( J:229481 )

• endoxifen-induced tumors show glial morphology with features typical of astrocytomas and oligodendrogliomas

increased oligodendroglioma incidence ( J:229481 )

• endoxifen-induced tumors show glial morphology with features typical of astrocytomas and oligodendrogliomas

nervous system

increased glioma incidence ( J:229481 )

• 3 of 16 mice injected with endoxifen develop glial tumors with lesions of different sizes and varying extents of infiltration

• small neoplastic lesions in endoxifen-induced mice arise from beneath the SVZ and extend into the striatum and dorsally into the corpus callosum

• larger tumors of endoxifen-induced mice show expansion into and a diffuse infiltration of the entire caudate nucleus

• some tumors contain areas of necrosis and occasional microvascular proliferations similar to those in malignant gliomas

increased astrocytoma incidence ( J:229481 )

• endoxifen-induced tumors show glial morphology with features typical of astrocytomas and oligodendrogliomas

increased oligodendroglioma incidence ( J:229481 )

• endoxifen-induced tumors show glial morphology with features typical of astrocytomas and oligodendrogliomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
high grade glioma		DOID:3070	OMIM:PS137800	J:229481

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor Pten^tm1Mro/Pten^tm1Mro Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (942 available)
Pten^tm1Mro mutation (1 available); any Pten mutation (81 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased glioma incidence ( J:229481 )

• mice injected with an adenovirus expressing cre recombinase (Ad-Cre) into the left ventricle exhibit a 33.3% incidence of glioma

increased astrocytoma incidence ( J:229481 )

• in left ventricle Ad-cre injected mice

increased oligodendroglioma incidence ( J:229481 )

• in left ventricle Ad-cre injected mice

nervous system

increased glioma incidence ( J:229481 )

• mice injected with an adenovirus expressing cre recombinase (Ad-Cre) into the left ventricle exhibit a 33.3% incidence of glioma

increased astrocytoma incidence ( J:229481 )

• in left ventricle Ad-cre injected mice

increased oligodendroglioma incidence ( J:229481 )

• in left ventricle Ad-cre injected mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
high grade glioma		DOID:3070	OMIM:PS137800	J:229481

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor Pten^tm1Mro/Pten^tm1Mro Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (942 available)
Pten^tm1Mro mutation (1 available); any Pten mutation (81 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased glioma incidence ( J:204385 )

• mice injected with an adenovirus expressing cre (adeno-cre) into the lateral ventricle develop a spectrum of gliomas, including anaplastic astrocytomas, oligodendrogliomas, and most commonly, anaplastic oligoastrocytomas

• however, adeno-cre injected mice do not develop glioblastoma with palisading necrosis or microvascular proliferation

• tumors in adeno-cre injected mice resemble The Cancer Genome Atlas (TCGA) classical glioblastomas, Phillips proneural and TACG neural gliomas

increased astrocytoma incidence ( J:204385 )

• mice injected with an adeno-cre into the lateral ventricle develop anaplastic oligoastrocytoma

• oligoastrocytomas do not resemble any human gliobastoma subtypes

increased oligodendroglioma incidence ( J:204385 )

• mice injected with an adeno-cre into the lateral ventricle develop oligodendrogliomas

nervous system

increased glioma incidence ( J:204385 )

• however, adeno-cre injected mice do not develop glioblastoma with palisading necrosis or microvascular proliferation

• tumors in adeno-cre injected mice resemble The Cancer Genome Atlas (TCGA) classical glioblastomas, Phillips proneural and TACG neural gliomas

increased astrocytoma incidence ( J:204385 )

• mice injected with an adeno-cre into the lateral ventricle develop anaplastic oligoastrocytoma

• oligoastrocytomas do not resemble any human gliobastoma subtypes

increased oligodendroglioma incidence ( J:204385 )

• mice injected with an adeno-cre into the lateral ventricle develop oligodendrogliomas

Allelic Composition	Pten^tm1Mro/Pten^tm1Mro Tg(KRT14-cre)8Brn/0 Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * DBA/2J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Mro mutation (1 available); any Pten mutation (81 available)
Tg(KRT14-cre)8Brn mutation (4 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:144831 )

• mice die by 20 weeks of age of unknown cause

neoplasm

increased carcinoma incidence ( J:144831 )

• all mice develop malignant carcinomas in the oral cavity or lips by 18 weeks of age

• tumors are similar to those that develop in Trp53^tm1Brn/Trp53^tm1Brn Tg(KRT14-cre)8Brn Tg(KRT5-Akt1*)Jmpa mice

behavior/neurological

weakness ( J:144831 )

• mice display a progressive weakening

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺ Pten^tm1Mro/Pten⁺ Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki} mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Pten^tm1Mro mutation (1 available); any Pten mutation (81 available)
Tg(Pbsn-cre)4Prb mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Prostate cancer progression in Tg(Pbsn-cre)4Prb/0 Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺, Tg(Pbsn-cre)4Prb/0 Pten^tm1Mro/Pten⁺, and Tg(Pbsn-cre)4Prb/0 Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺ Pten^tm1Mro/Pten⁺ mice

neoplasm

increased prostate gland adenocarcinoma incidence ( J:184533 )

• 55% penetrance at 1 year

• multifocal, predominantly localized in the dorsolateral lobe that are locally invasive and highly vascularized

increased prostate intraepithelial neoplasia incidence ( J:184533 )

• at 6 months

renal/urinary system

urinary bladder obstruction ( J:184533 )

• frequently

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:184533 )

• 55% penetrance at 1 year

• multifocal, predominantly localized in the dorsolateral lobe that are locally invasive and highly vascularized

increased prostate intraepithelial neoplasia incidence ( J:184533 )

• at 6 months

reproductive system

increased prostate gland adenocarcinoma incidence ( J:184533 )

• 55% penetrance at 1 year

• multifocal, predominantly localized in the dorsolateral lobe that are locally invasive and highly vascularized

increased prostate intraepithelial neoplasia incidence ( J:184533 )

• at 6 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:184533

Allelic Composition	Pten^tm1Mro/Pten⁺ Tg(KLK3-cre)D4Trp/0
Genetic Background	involves: 129P2/OlaHsd * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Mro mutation (1 available); any Pten mutation (81 available)
Tg(KLK3-cre)D4Trp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal prostate gland epithelium morphology ( J:99524 )

• at 4-5 months, epithelial cell lining of prostate tubules is disorganized, with tufting and/or cribriform growth patterns, unlike the regularly-layered columnar epithelial lining in controls

• epithelial cells are generally enlarged with some foci showing dysplasia characterized by cells with dense cytoplasm enlarged, somewhat vesicular nuclei with conspicuous nuclei

• at 7-9 months, distention of glands continues, with dysplasia becoming more diffuse

increased prostate gland weight ( J:99524 )

• prostate lobes are obviously enlarged compared with control prostates; at 4-5 months, average weight is increased 2-fold and at 7-9 months increase is 3-fold

• at 14 months with prostate cancer, weight has rapidly increased

prostate gland hyperplasia ( J:99524 )

• at 4-5 months of age, most glands of the different lobes show hyperplasia with accumulation of luminal cells, with distension of individual preexisting glands

• at 7-9 months hyperplasia continues to progress

increased prostate gland tumor incidence ( J:99524 )

• progressive tumor development is observed in mice at 4-5 months along with focal prostatic intraepithelial neoplasia (PIN) lesions, 7-9 months with more widespread PIN and focal microinvasion and at 10-14 months with invasive tumors

• in 14-month old mice, tumors are all shown to be epithelial in origin, classified as adenocarcinoma of poor, low or moderate grade differentiation

increased prostate gland adenocarcinoma incidence ( J:99524 )

increased prostate intraepithelial neoplasia incidence ( J:99524 )

endocrine/exocrine glands

abnormal prostate gland epithelium morphology ( J:99524 )

• at 4-5 months, epithelial cell lining of prostate tubules is disorganized, with tufting and/or cribriform growth patterns, unlike the regularly-layered columnar epithelial lining in controls

• epithelial cells are generally enlarged with some foci showing dysplasia characterized by cells with dense cytoplasm enlarged, somewhat vesicular nuclei with conspicuous nuclei

• at 7-9 months, distention of glands continues, with dysplasia becoming more diffuse

increased prostate gland weight ( J:99524 )

• prostate lobes are obviously enlarged compared with control prostates; at 4-5 months, average weight is increased 2-fold and at 7-9 months increase is 3-fold

• at 14 months with prostate cancer, weight has rapidly increased

prostate gland hyperplasia ( J:99524 )

• at 4-5 months of age, most glands of the different lobes show hyperplasia with accumulation of luminal cells, with distension of individual preexisting glands

• at 7-9 months hyperplasia continues to progress

increased prostate gland tumor incidence ( J:99524 )

• in 14-month old mice, tumors are all shown to be epithelial in origin, classified as adenocarcinoma of poor, low or moderate grade differentiation

increased prostate gland adenocarcinoma incidence ( J:99524 )

increased prostate intraepithelial neoplasia incidence ( J:99524 )

neoplasm

increased prostate gland tumor incidence ( J:99524 )

• in 14-month old mice, tumors are all shown to be epithelial in origin, classified as adenocarcinoma of poor, low or moderate grade differentiation

increased prostate gland adenocarcinoma incidence ( J:99524 )

increased prostate intraepithelial neoplasia incidence ( J:99524 )

Allelic Composition	Pten^tm1Mro/Pten^tm1Mro Tg(KLK3-cre)D4Trp/0
Genetic Background	involves: 129P2/OlaHsd * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Mro mutation (1 available); any Pten mutation (81 available)
Tg(KLK3-cre)D4Trp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

prostate gland epithelial hyperplasia ( J:99524 )

• mutants show a 2-fold higher number of proliferating (BrdU-positive) cells at 4-5, 7-9, and 10-14 months

endocrine/exocrine glands

prostate gland epithelial hyperplasia ( J:99524 )

• mutants show a 2-fold higher number of proliferating (BrdU-positive) cells at 4-5, 7-9, and 10-14 months

Allelic Composition	Pten^tm1Mro/Pten^tm1Mro Sdhb^tm1.1Ics/Sdhb^tm1.2Ics Tg(KLK3-cre)D4Trp/0
Genetic Background	involves: 129S2/SvPas * BALB/c * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Mro mutation (1 available); any Pten mutation (81 available)
Sdhb^tm1.1Ics mutation (0 available); any Sdhb mutation (27 available)
Sdhb^tm1.2Ics mutation (0 available); any Sdhb mutation (27 available)
Tg(KLK3-cre)D4Trp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased pheochromocytoma incidence ( J:236514 )

• 42% incidence of pheochromocytoma

• tumors do not show accumulation of succinate

neoplasm

increased pheochromocytoma incidence ( J:236514 )

• 42% incidence of pheochromocytoma

• tumors do not show accumulation of succinate

Allelic Composition	Pten^tm1Mro/Pten^tm1Mro Sdhb^tm1.1Ics/Sdhb⁺ Tg(KLK3-cre)D4Trp/0
Genetic Background	involves: 129S2/SvPas * FVB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased pheochromocytoma incidence ( J:236514 )

• 89% of mice show pheochromocytoma at 12.9 months of age

• tumors do not show accumulation of succinate

neoplasm

increased pheochromocytoma incidence ( J:236514 )

• 89% of mice show pheochromocytoma at 12.9 months of age

• tumors do not show accumulation of succinate

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pheochromocytoma		DOID:0050771	OMIM:171300	J:236514

Allelic Composition	Pten^tm1Mro/Pten⁺ Sdhb^tm1.1Ics/Sdhb⁺ Tg(KLK3-cre)D4Trp/0
Genetic Background	involves: 129S2/SvPas * FVB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased pheochromocytoma incidence ( J:236514 )

• 64% of mice develop pheochromocytoma

neoplasm

increased pheochromocytoma incidence ( J:236514 )

• 64% of mice develop pheochromocytoma

Allelic Composition	Pten^tm1Mro/Pten⁺ Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Mro mutation (1 available); any Pten mutation (81 available)
Tg(Pbsn-cre)4Prb mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:184533 )

• in 40% of mice at 9 months

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:184533 )

• in 40% of mice at 9 months

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:184533 )

• in 40% of mice at 9 months

Allelic Composition	Pten^tm1Mro/Pten^tm1Mro Tg(Pcp2-cre)756Mro/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Mro mutation (1 available); any Pten mutation (81 available)
Tg(Pcp2-cre)756Mro mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar Purkinje cell layer ( J:77123 )

• mice exhibit subtle irregularities in the Purkinje cell lining compared to in wild-type mice

abnormal Purkinje cell morphology ( J:77123 )

• increased in size compared to in wild-type mice

Purkinje cell degeneration ( J:77123 )

• at 17 and 20 weeks

abnormal Purkinje cell dendrite morphology ( J:77123 )

• dendrites and descending axons are thickened compared to in wild-type mice

Allelic Composition	Pten^tm1Mro/Pten^tm1Mro Tg(En2-cre)22Alj/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Mro mutation (1 available); any Pten mutation (81 available)
Tg(En2-cre)22Alj mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuronal migration ( J:77123 )

• migration of Purkinje cells is impaired with the majority of cells clustering above the fourth ventricle without recognizable orientation

• Golgi, stellate, basket, Bergmann glial and oligodendrocyte cells fail to migrate properly and are randomly distributed throughout the cerebellum

abnormal cerebellum morphology ( J:77123 )

• at P1 and P9, cerebellar cell proliferation is increased and cell death is decreased compared to in wild-type mice

abnormal cerebellum development ( J:77123 )

• at E15.5, mice exhibit increased precursor cell size resulting in an increase in cerebellar anlage size

• at E15.5, cerebellar cell proliferation is increased and cell death is decreased compared to in wild-type mice

absent cerebellar foliation ( J:77123 )

• at P1

abnormal cerebellum external granule cell layer morphology ( J:77123 )

• thickened

Purkinje cell degeneration ( J:77123 )

ectopic Purkinje cell ( J:77123 )

• several Purkinje cells migrate towards the cerebellar surface and intermingle with granule cells

abnormal cerebellar molecular layer ( J:77123 )

• unlike in wild-type mice, mature granule cells are found within the molecular layer due to disrupted migration

abnormal cerebellum vermis morphology ( J:77123 )

• the cerebellar vermis is enlarged after 3 weeks

enlarged cerebellum ( J:77123 )

behavior/neurological

ataxia ( J:77123 )

• after 3 weeks mice exhibit ataxia that worsens until 8 weeks of age

impaired balance ( J:77123 )

• after 3 weeks

decreased locomotor activity ( J:77123 )

• after 3 weeks

neoplasm

neoplasm ( J:77123 )

N	• despite the loss of Pten in several human tumors including glioblastoma, mice do not exhibit any neoplastic transformation

cellular

abnormal neuronal migration ( J:77123 )

• migration of Purkinje cells is impaired with the majority of cells clustering above the fourth ventricle without recognizable orientation

• Golgi, stellate, basket, Bergmann glial and oligodendrocyte cells fail to migrate properly and are randomly distributed throughout the cerebellum

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