Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Diablotm1Mak mutation
(1 available);
any
Diablo mutation
(13 available)
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normal phenotype
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• viable and fertile; no gross morphological or histological abnormalities
• normal induction of apoptosis in UV-irradiated or Fas-antibody treated cells was noted
• mice also exhibit normal T and B cell proliferative responses
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Diablotm1Mak mutation
(1 available);
any
Diablo mutation
(13 available)
Htra2tm1Jdo mutation
(0 available);
any
Htra2 mutation
(19 available)
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behavior/neurological
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• progressive movement disorder beginning at P18, identical to the phenotype observed in homozygous Prss25 null mice
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cellular
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• increased sensitivity to apoptosis induction by DNA-damaging agent etoposide
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growth/size/body
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• failed to gain weight after P18 and exhibited a phenotype identical to homozygous Prss25 null mice
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