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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fancgtm1Ada
targeted mutation 1, Alan D'Andrea
MGI:2183264
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fancgtm1Ada/Fancgtm1Ada involves: 129S4/SvJae * C57BL/6 MGI:3621365


Genotype
MGI:3621365
hm1
Allelic
Composition
Fancgtm1Ada/Fancgtm1Ada
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancgtm1Ada mutation (0 available); any Fancg mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• ovaries are almost completely devoid of follicles
• testes are mosaic for normal and abnormal tubules
• abnormal tubules are devoid of spermatocytes,containing only Sertoli cells
• testis weight is approximately 50% of normal
• matings of homzygotes maintained for as long as 6 months produce no offspring

endocrine/exocrine glands
• ovaries are almost completely devoid of follicles
• testes are mosaic for normal and abnormal tubules
• abnormal tubules are devoid of spermatocytes,containing only Sertoli cells
• testis weight is approximately 50% of normal

cellular
• primary splenic lymphocytes, bone marrow progenitor cells, and embryo fibroblast cells show increased sensitivity to mitomycin C and ionizing radiation
• primary splenic lymphocytes, bone marrow progenitor cells, and embryo fibroblasts show spontaneous breakage





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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory