Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgals3tm1Poi mutation
(4 available);
any
Lgals3 mutation
(26 available)
|
|
|
adipose tissue
|
|
• 6-7 month old mice exhibit an increase in adiposity
|
behavior/neurological
|
|
• 2-3 and 6-7 month old mice exhibit less total movement compared to wild-type mice, especially during the circadian dark cycle
|
|
|
• 2-3 and 6-7 month old mice exhibit decreased movement-in-place behaviors due to decreased bout numbers, initiation rates, and durations
• 6-7 month old mice exhibit decreased forward locomotion due to decreased bout numbers, initiation rates, and durations
|
|
|
• 2-3 and 6-7 month old mice exhibit perturbed behavioral circadian rhythms, with greater day-to-day variability in feeding, drinking, and movement
|
growth/size/body
|
|
• 6-7, but not 2-3, month old mice exhibit greater body weights
|
skeleton
|
|
• 6-7 month old mice exhibit an increase in bone mineral density
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgals3tm1Poi mutation
(4 available);
any
Lgals3 mutation
(26 available)
|
|
|
mortality/aging
|
N |
• mice exhibit a normal lifespan
|
reproductive system
|
N |
• mice exhibit normal reproduction
|
integument
|
N |
• mice exhibit normal skin structure
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgals3tm1Poi mutation
(4 available);
any
Lgals3 mutation
(26 available)
|
|
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgals3tm1Poi mutation
(4 available);
any
Lgals3 mutation
(26 available)
|
|
|
hematopoietic system
|
|
• while recruitment of granulocytes following treatment with thioglycolate is normal, granulocyte numbers 3 to 4 days after treatment are reduced 4-fold compared to in wild-type mice
• however, granulocyte apoptosis rates and phagocytosis of apoptotic granulocytes are normal
|
immune system
|
|
• while recruitment of granulocytes following treatment with thioglycolate is normal, granulocyte numbers 3 to 4 days after treatment are reduced 4-fold compared to in wild-type mice
• however, granulocyte apoptosis rates and phagocytosis of apoptotic granulocytes are normal
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgals3tm1Poi mutation
(4 available);
any
Lgals3 mutation
(26 available)
|
|
|
mortality/aging
|
|
• mice infected with S. pneumoniae exhibit high mortality after 24 hours
|
immune system
|
|
• 15 hours after infection with S. pneumoniae
• however, myeloperoxidase activity is similar to in wild-type mice 15 hours after infection with S. pneumoniae
|
|
|
• macrophage activation by IL-4 and IL-13 stimulation Is impaired
• however, macrophage activation by IFN-gamma and LPS is normal
|
|
|
• when stimulated by IL-4 and IL-13
|
|
|
• phagocytosis of apoptotic neutrophils by bone marrow-derived macrophages is impaired
• however, phagocytosis of S. pneumonia is normal
|
|
|
• 15 hours after infection with S. pneumoniae, IL-6 concentration in bronchoalveolar lavage is increased compared to in wild-type mice
|
|
|
• 15 hours after infection with S. pneumoniae, TNF-alpha concentration in bronchoalveolar lavage is increased compared to in wild-type mice
|
|
|
• after 15 hours, mice infected with S. pneumoniae exhibit increased cell infiltrate in the lungs and develop severe pneumonia with increased lung injury and septicemia compared to wild-type mice
|
|
|
• mice infected with S. pneumoniae exhibit high mortality after 24 hours
• after 15 hours, mice infected with S. pneumoniae exhibit increased cell infiltrate but decreased total cell counts in the lungs and develop severe pneumonia with increased lung injury and septicemia compared to wild-type mice
• after 15 hours, mice infected with S. pneumoniae exhibit a 450-fold increase in bacterial load compared to wild-type mice and blood cultures indicate 100 % bacteremia compared to 30% in wild-type mice
|
|
|
• after 15 hours, mice infected with S. pneumoniae exhibit septicemia unlike wild-type mice
|
skeleton
|
|
• unlike in wild-type mice, a large zone of empty lacunae is observed between the last row of hypertrophic cells and the vascular invasion front
|
|
|
• chondrocytes within the hypertrophic zone are larger and more vacuolated than in wild-type mice
• mice exhibit an increased number of nonhypertrophic cells in the late hyprtrophic zone compared to in wild-type mice
• chondrocytes in the zone contain unusually large intracellular glycogen aggregates
|
|
|
• the hypertrophic zone is reduced in size and contains 20% fewer hypertrophic cells than in wild type mice
|
renal/urinary system
|
|
• mice exhibit less renal fibrosis following unilateral ureter obstruction (UUO) compared to wild-type mice
• however, macrophage recruitment and cytokine production induced by UUO is normal
|
respiratory system
|
|
• after 15 hours, mice infected with S. pneumoniae exhibit increased cell infiltrate in the lungs and develop severe pneumonia with increased lung injury and septicemia compared to wild-type mice
|
homeostasis/metabolism
cellular
|
|
• when stimulated by IL-4 and IL-13
|
|
|
• phagocytosis of apoptotic neutrophils by bone marrow-derived macrophages is impaired
• however, phagocytosis of S. pneumonia is normal
|
hematopoietic system
|
|
• 15 hours after infection with S. pneumoniae
• however, myeloperoxidase activity is similar to in wild-type mice 15 hours after infection with S. pneumoniae
|
|
|
• macrophage activation by IL-4 and IL-13 stimulation Is impaired
• however, macrophage activation by IFN-gamma and LPS is normal
|
|
|
• when stimulated by IL-4 and IL-13
|
|
|
• phagocytosis of apoptotic neutrophils by bone marrow-derived macrophages is impaired
• however, phagocytosis of S. pneumonia is normal
|
mortality/aging
|
N |
• mice exhibit a normal lifespan
|
reproductive system
|
N |
• mice exhibit normal reproduction
|
integument
|
N |
• mice exhibit normal skin structure
|
cardiovascular system
|
|
• at 25 to 31 weeks of age, mice exhibit a lower number inflammatory infiltrate and mast cells in adventitia than Apoetm1Unc homozygotes
• at 36 to 44 months of age, mice exhibit fewer atherosclerotic lesions and atheromatous plaques compared to in Apoetm1Unc homozygotes and do not exhibit an age-related increase in lesion number, athlerosclerotic microaneurysms or periaortic vascular channels that are evident in Apoetm1Unc homozygotes
|
homeostasis/metabolism
Analysis Tools