Mouse Genome Informatics
hm1
    Efna2tm1Jgf/Efna2tm1Jgf
involves: 129/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• increased neurogenesis with increased progenitor cell proliferation in the lateral ventricle wall that is paralleled by a similar increase in the integration of neurons in the olfactory bulb
• increased BrdU incorporation and shortened cell cycle in progenitor cells in the lateral ventricle wall of adult brain and increased proliferation of neural progenitor cells in vitro
• increased number of newborn neurons in the olfactory bulb, indicating that migration of neurons from the lateral ventricle wall to the olfactory bulb is not impeded
• 44% increase in the number of BrdU-labeled cells that integrate in the adult olfactory bulb, a 15% increase in cell density and 7% increase in cell number in the adult olfactory bulb

cellular
• increased neurogenesis with increased progenitor cell proliferation in the lateral ventricle wall that is paralleled by a similar increase in the integration of neurons in the olfactory bulb


Mouse Genome Informatics
hm2
    Efna2tm1Jgf/Efna2tm1Jgf
involves: 129S6/SvEvTac
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• although arborization of temporal axons from the retina is normal, 57% of mice show additional posterior arborization


Mouse Genome Informatics
cx3
    Efna2tm1Jgf/Efna2tm1Jgf
Efna5tm1Ddmo/Efna5tm1Ddmo

involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• ectopic arborization of both retinal temporal axons and nasal axons are more sever than in singly homozygous mice
• usually multiple ectopic arborizations are seen
• normal arborization sometimes lost


Mouse Genome Informatics
cx4
    Efna2tm1Jgf/Efna2+
Efna5tm1Ddmo/Efna5+

involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• single ectopic arborizations of temporal axons from the retina but normal nasal arborizations


Mouse Genome Informatics
cx5
    Efna2tm1Jgf/Efna2tm1Jgf
Efna3tm1Rax/Efna3tm1Rax
Efna5tm1Ddmo/Efna5tm1Ddmo

involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• localization of innervations from the optic nerve to the dorsal lateral geniculate body are defective