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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Efna2tm1Jgf
targeted mutation 1, John G Flanagan
MGI:2182943
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Efna2tm1Jgf/Efna2tm1Jgf involves: 129/Sv * C57BL/6 MGI:3575395
hm2
Efna2tm1Jgf/Efna2tm1Jgf involves: 129S6/SvEvTac MGI:3689582
cx3
Efna2tm1Jgf/Efna2tm1Jgf
Efna5tm1Ddmo/Efna5tm1Ddmo
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ MGI:3689619
cx4
Efna2tm1Jgf/Efna2+
Efna5tm1Ddmo/Efna5+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ MGI:3689620
cx5
Efna2tm1Jgf/Efna2tm1Jgf
Efna3tm1Rax/Efna3tm1Rax
Efna5tm1Ddmo/Efna5tm1Ddmo
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 MGI:3605233
cx6
Efna2tm1Jgf/Efna2tm1Jgf
Efna3tm1Rax/Efna3tm1Rax
involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster MGI:5638914


Genotype
MGI:3575395
hm1
Allelic
Composition
Efna2tm1Jgf/Efna2tm1Jgf
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efna2tm1Jgf mutation (1 available); any Efna2 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increased neurogenesis with increased progenitor cell proliferation in the lateral ventricle wall that is paralleled by a similar increase in the integration of neurons in the olfactory bulb
• increased BrdU incorporation and shortened cell cycle in progenitor cells in the lateral ventricle wall of adult brain and increased proliferation of neural progenitor cells in vitro
• increased number of newborn neurons in the olfactory bulb, indicating that migration of neurons from the lateral ventricle wall to the olfactory bulb is not impeded
• 44% increase in the number of BrdU-labeled cells that integrate in the adult olfactory bulb, a 15% increase in cell density and 7% increase in cell number in the adult olfactory bulb

cellular
• increased neurogenesis with increased progenitor cell proliferation in the lateral ventricle wall that is paralleled by a similar increase in the integration of neurons in the olfactory bulb




Genotype
MGI:3689582
hm2
Allelic
Composition
Efna2tm1Jgf/Efna2tm1Jgf
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efna2tm1Jgf mutation (1 available); any Efna2 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• although arborization of temporal axons from the retina is normal, 57% of mice show additional posterior arborization




Genotype
MGI:3689619
cx3
Allelic
Composition
Efna2tm1Jgf/Efna2tm1Jgf
Efna5tm1Ddmo/Efna5tm1Ddmo
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efna2tm1Jgf mutation (1 available); any Efna2 mutation (10 available)
Efna5tm1Ddmo mutation (1 available); any Efna5 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• ectopic arborization of both retinal temporal axons and nasal axons are more sever than in singly homozygous mice
• usually multiple ectopic arborizations are seen
• normal arborization sometimes lost




Genotype
MGI:3689620
cx4
Allelic
Composition
Efna2tm1Jgf/Efna2+
Efna5tm1Ddmo/Efna5+
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efna2tm1Jgf mutation (1 available); any Efna2 mutation (10 available)
Efna5tm1Ddmo mutation (1 available); any Efna5 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• single ectopic arborizations of temporal axons from the retina but normal nasal arborizations




Genotype
MGI:3605233
cx5
Allelic
Composition
Efna2tm1Jgf/Efna2tm1Jgf
Efna3tm1Rax/Efna3tm1Rax
Efna5tm1Ddmo/Efna5tm1Ddmo
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efna2tm1Jgf mutation (1 available); any Efna2 mutation (10 available)
Efna3tm1Rax mutation (0 available); any Efna3 mutation (4 available)
Efna5tm1Ddmo mutation (1 available); any Efna5 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• localization of innervations from the optic nerve to the dorsal lateral geniculate body are defective




Genotype
MGI:5638914
cx6
Allelic
Composition
Efna2tm1Jgf/Efna2tm1Jgf
Efna3tm1Rax/Efna3tm1Rax
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efna2tm1Jgf mutation (1 available); any Efna2 mutation (10 available)
Efna3tm1Rax mutation (0 available); any Efna3 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants do not exhibit deficits in cue-related or context-related fear conditioning, but time spent freezing remains increased for all testing 24 hours after conditioning
• mutants exhibit a different swim pattern than wild-type mice in the Morris water maze, with a tendency to exhibit small spiral swim patterns along the wall of the pool interrupted by bursts of random swimming that criss-cross the maze compared to wild-type mice that show a combination of large circular swim patterns interspersed with some cross-maze swimming
• in the probe trail, mutants, but not wild-type mice, tend to revert back to their swim patterns during early training
• however, mutants are able to learn the new location of the hidden quadrant during reversal training of the Morris water maze
• although mutants exhibit a normal exploratory response to a novel environment, they engage in exploratory behavior less in the second 10 min of testing than wild-type mice, engaging mostly in grooming behaviors during the non-exploratory time
• mutants bury fewer marbles than wild-type mice
• mutants exhibit increased thigmotaxis in the open field
• however, mice show similar behavior as wild-type mice in the elevated plus maze
• mutants exhibit compulsive facial grooming that becomes apparent around 3 months of age and increases in severity over time, leading to hair loss or skin lesions at site of over-grooming between 4-6 months of age
• mutants engage in exploratory behavior less the second 10 min of testing than wild-type mice, engaging mostly in grooming behaviors during the non-exploratory time
• mutants spend more time grooming during the 5 minutes after receiving a facial spritz of water
• mutants exhibit an attenuated auditory startle compared to wild-type mice on the trials without prepulses
• mutants rear fewer times than wild-type mice
• in the open field, mutants travel less distance than wild-type mice
• mutants are hypolocomotive and this hypoactivity does not change over time, however, the decline in exploratory activity is similar to wild-type mice
• however, mice exhibit normal gait and ambulatory coordination
• in the three-chamber social behavior assay, mutants show less spontaneous locomotor activity
• in the three-chamber social behavior assay, mutants show a social aversion, with social index values less than in wild-type mice

nervous system
• abrasive lesions around the eyes due to excessive grooming are nearly always more severe on the side where the ear tag is placed, suggesting sensorimotor gating problems
• mutants have greater prepulse inhibition (PPI) of acoustic startle response than wild-type mice at all prepulse intensities (3 dB, 6 dB, and 12 dB) tested and there is a greater percent increase in PPI with increasing prepulse intensities

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:216970





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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory