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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tnfrsf13btm1Vmd
targeted mutation 1, Vishva M Dixit
MGI:2182823
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd involves: C57BL/6 MGI:3847256


Genotype
MGI:3847256
hm1
Allelic
Composition
Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf13btm1Vmd mutation (0 available); any Tnfrsf13b mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 40% of mice die by 18 months of age

immune system
• total B cell numbers in the spleen and mesenteric lymph nodes is about double of controls (J:70172)
• B cell numbers are increased 2-3 fold in the spleen and lymph nodes (J:82331)
• the number of T1 B cells found in the spleen is about double of controls
• number of mature B cells in the spleen is about double of controls
• number of follicular B cells in the spleen is 3 fold higher than controls
• number of marginal zone B cells in the spleen is 4-5 fold higher than controls
• spleen of mice is enlarged (J:70172)
• spleen of mice is enlarged (J:82331)
• B cell follicles are expanded in cellularity and size
• germinal centers are expanded in these mice
• the PALS region appears expanded in the spleen despite the presence of normal number of T cells (J:70172)
• PALS area is increased (J:82331)
• white pulp is expanded by increased numbers of follicle and marginal zone B cells
• B cells hyperproliferate in vitro in response to mitogenic or costimulatory stimuli
• B cells also hyperproliferate in response to Tnfsf13b ligand (BAFF, Blys)
• B cells produce higher levels of immunoglobulins in vitro in response to anti-CD40 stimulus
• mice have 70% higher levels of total and antigen-specific IgG1 in response to immunization with a thymus-dependent antigen
• mice have 70% higher levels of total and antigen-specific IgG1 in response to immunization with a thymus-dependent antigen
• B cell follicles are inconsistently expanded in cellularity and size
• B cell follicles are inconsistently expanded in cellularity and size (J:70172)
• follicle size is increased in these mice (J:82331)
• axillary and mesenteric lymph nodes are enlarged (J:70172)
• lymph nodes are enlarged (J:82331)
• titers of anti-nuclear antibodies are much higher than controls
• titers of anti-dsDNA are much higher than controls
• lymphocytic infiltrate is observed in the liver
• lymphocytic infiltrate is observed in the kidney
• kidneys have mesangial proliferation and inflammatory cell infiltrates
• fibroid necrosis and sclerosis are visible in affected glomeruli with occasional crescent formation
• significant deposition of IgG is detectable in the glomeruli of 90% of mice

renal/urinary system
• levels of proteinuria gradually increase until by 7 months of age all mice have proteinurea greater than 100 mg/dl and 90% of proteinura greater than 300 mg/dl
• lymphocytic infiltrate is observed in the kidney
• significant deposition of IgG is detectable in the glomeruli of 90% of mice
• fibroid necrosis and sclerosis are visible in affected glomeruli with occasional crescent formation
• kidneys have mesangial proliferation and inflammatory cell infiltrates
• occasional crescent formation

homeostasis/metabolism
• levels of proteinuria gradually increase until by 7 months of age all mice have proteinurea greater than 100 mg/dl and 90% of proteinura greater than 300 mg/dl

liver/biliary system
• lymphocytic infiltrate is observed in the liver

hematopoietic system
• total B cell numbers in the spleen and mesenteric lymph nodes is about double of controls (J:70172)
• B cell numbers are increased 2-3 fold in the spleen and lymph nodes (J:82331)
• the number of T1 B cells found in the spleen is about double of controls
• number of mature B cells in the spleen is about double of controls
• number of follicular B cells in the spleen is 3 fold higher than controls
• number of marginal zone B cells in the spleen is 4-5 fold higher than controls
• spleen of mice is enlarged (J:70172)
• spleen of mice is enlarged (J:82331)
• B cell follicles are expanded in cellularity and size
• germinal centers are expanded in these mice
• the PALS region appears expanded in the spleen despite the presence of normal number of T cells (J:70172)
• PALS area is increased (J:82331)
• white pulp is expanded by increased numbers of follicle and marginal zone B cells
• B cells hyperproliferate in vitro in response to mitogenic or costimulatory stimuli
• B cells also hyperproliferate in response to Tnfsf13b ligand (BAFF, Blys)
• B cells produce higher levels of immunoglobulins in vitro in response to anti-CD40 stimulus
• mice have 70% higher levels of total and antigen-specific IgG1 in response to immunization with a thymus-dependent antigen
• mice have 70% higher levels of total and antigen-specific IgG1 in response to immunization with a thymus-dependent antigen

neoplasm
• about 15 % of mice develop a B cell leukemia by 8 months of age
• leukemia infiltrates both spleen and liver
• cells have basophilic cytosol, indistinct cell borders, oval open faced nuclei, and express B220





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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory