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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ets1tm2Jml
targeted mutation 2, Jeffrey M Leiden
MGI:2182780
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ets1tm2Jml/Ets1tm2Jml involves: 129X1/SvJ * C57BL/6 MGI:3608775


Genotype
MGI:3608775
hm1
Allelic
Composition
Ets1tm2Jml/Ets1tm2Jml
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1tm2Jml mutation (0 available); any Ets1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• splenic T cells display a defect in activation following cross-linking of the T cell receptor

mortality/aging
• approximately 50% of homozygotes survive until 4 weeks of age

hematopoietic system
N
• normal numbers of splenic IgM+ B220+ B cells
• splenocytes have normal expression of IL2RB, IL2RG, IL15RA and IL18
• increased numbers of splenic and lymph node plasma cells with serum IgM levels elevated by approximately 5 fold
• reduced NK cell numbers evidenced by diminished splenic DX5+ CD3- cells and diminished splenic NK1.1+ CD3- cells
• lymph nodes and bone marrow do not contain detectable DX5+ CD3- cells
• slightly reduced numbers of splenic T cells, particularly CD8+ T cells
• 4 to 8 week old homozygotes have approximately 65% reduction in thymocyte numbers with low levels of CD4 expressed on many CD8+ thymocytes
• poly (I:C) stimulated splenocytes produce reduced amounts of IFNG and IL12
• splenocytes fail to lyse YAC-1 tumor cells, B2m-/- lyphoid blasts, and MHC class I deficient RMA-S tumor cells are not rejected at a normal rate in vivo
• addition of IL12, IL2 and IL15 fails to restore YAC-1 cytolysis
• splenic T cells display a defect in activation following cross-linking of the T cell receptor

immune system
• increased numbers of splenic and lymph node plasma cells with serum IgM levels elevated by approximately 5 fold
• reduced NK cell numbers evidenced by diminished splenic DX5+ CD3- cells and diminished splenic NK1.1+ CD3- cells
• lymph nodes and bone marrow do not contain detectable DX5+ CD3- cells
• slightly reduced numbers of splenic T cells, particularly CD8+ T cells
• 4 to 8 week old homozygotes have approximately 65% reduction in thymocyte numbers with low levels of CD4 expressed on many CD8+ thymocytes
• poly (I:C) stimulated splenocytes produce reduced amounts of IFNG and IL12
• splenocytes fail to lyse YAC-1 tumor cells, B2m-/- lyphoid blasts, and MHC class I deficient RMA-S tumor cells are not rejected at a normal rate in vivo
• addition of IL12, IL2 and IL15 fails to restore YAC-1 cytolysis
• splenic T cells display a defect in activation following cross-linking of the T cell receptor

endocrine/exocrine glands
• 4 to 8 week old homozygotes have approximately 65% reduction in thymocyte numbers with low levels of CD4 expressed on many CD8+ thymocytes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory