Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc2tm1Rao mutation
(3 available);
any
Nfatc2 mutation
(53 available)
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immune system
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• activated mast cells fail to produce IL-4 after stimulation
• IL-13 and TNF production is also reduced
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• IL-13 production by activated mast cells is reduced
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• mast cells fail to produce IL-4 after stimulation
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• TNF production by activated mast cells is reduced
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hematopoietic system
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• activated mast cells fail to produce IL-4 after stimulation
• IL-13 and TNF production is also reduced
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immune system
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• stimulated B cells exhibit reduced ability to induced T cell proliferation
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• from stimulated B cells
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hematopoietic system
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• stimulated B cells exhibit reduced ability to induced T cell proliferation
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc2tm1Rao mutation
(3 available);
any
Nfatc2 mutation
(53 available)
Nfatc3tm1Grc mutation
(0 available);
any
Nfatc3 mutation
(70 available)
Tg(Lck-cre)I57Jxm mutation
(1 available)
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immune system
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• the rate of T cells undergoing apoptosis in culture is slightly greater than in wild-type and Nfatc3tm1Grc/Nfatc3tm1Grc Tg(Lck-cre)I57Jxm mice
• however, the number of T cells initially undergoing apoptosis is normal
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• T cell development is partially blocked after pre-TCR signaling and the DN4 population is reduced compared to in wild-type mice but is not more severe than in Nfatc3tm1Grc/Nfatc3tm1Grc Tg(Lck-cre)I57Jxm mice
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• mice exhibit an increase in DN1 and subsequently a more severe decrease in the number of DN4 T cells compared to in wild-type, Nfactc3 null or Nfact2 null mice
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hematopoietic system
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• the rate of T cells undergoing apoptosis in culture is slightly greater than in wild-type and Nfatc3tm1Grc/Nfatc3tm1Grc Tg(Lck-cre)I57Jxm mice
• however, the number of T cells initially undergoing apoptosis is normal
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• T cell development is partially blocked after pre-TCR signaling and the DN4 population is reduced compared to in wild-type mice but is not more severe than in Nfatc3tm1Grc/Nfatc3tm1Grc Tg(Lck-cre)I57Jxm mice
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• mice exhibit an increase in DN1 and subsequently a more severe decrease in the number of DN4 T cells compared to in wild-type, Nfactc3 null or Nfact2 null mice
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cellular
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• the rate of T cells undergoing apoptosis in culture is slightly greater than in wild-type and Nfatc3tm1Grc/Nfatc3tm1Grc Tg(Lck-cre)I57Jxm mice
• however, the number of T cells initially undergoing apoptosis is normal
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