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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Itgb1tm1Ehi
targeted mutation 1, Emilio Hirsch
MGI:2182640
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Itgb1tm1Ehi/Itgb1tm1Ehi either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) MGI:3703327


Genotype
MGI:3703327
hm1
Allelic
Composition
Itgb1tm1Ehi/Itgb1tm1Ehi
Genetic
Background
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm1Ehi mutation (0 available); any Itgb1 mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Developmental defects in Itgb1tm1Ehi/Itgb1tm1Ehi embryos

mortality/aging

growth/size/body
• appear much smaller than wild-type at E11.5

embryo
• when the allantois is not fused to the chorion, embryos appear abnormally oriented in the decidua
• appear much smaller than wild-type at E11.5
• 90% exhibit abnormally waved or kinky neural tubes at E10.5
• 90% exhibit abnormally waved or kinky neural tubes at E10.5
• at E10.5, 90% of embryos show failure of the allantois to fuse with the chorion

cardiovascular system
• aberrant mesenchyme development with a decrease in density of mesenchymal cells
• at E9.5, 95% of embryos display cardiac abnormalities and/or craniofacial abnormalities
• embryos exhibit a disconnection between myocardium and pericardium
• variable penetrance of pericardial effusion at E10.5, ranging from mild liquid accumulation in the pericardial cavity to severe pericardial swelling
• embryos exhibit blood leakage into the yolk sac and exocoelom

nervous system
• 90% exhibit abnormally waved or kinky neural tubes at E10.5
• 90% exhibit abnormally waved or kinky neural tubes at E10.5
• 20% show exencephaly at E10.5

craniofacial
• at E9.5, 95% of embryos display cardiac abnormalities and/or craniofacial abnormalities

cellular
• MEFs display a defective cell cycle, with a 25% increase of cells in G1, a 30% decrease of cells in S phase and a 76% decrease of cells in G2, indicating an impaired G1/S transition
• E9.5 embryos show an increase in the number of apoptotic cells in the mesenchyme and the heart
• E8.5 and E9.5 embryos show a 10% and 30% decrease of proliferating cells, respectively
• MEFs display impaired proliferation and survival and reduced adhesion-mediated cell survival

homeostasis/metabolism
• variable penetrance of pericardial effusion at E10.5, ranging from mild liquid accumulation in the pericardial cavity to severe pericardial swelling





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory