Phenotypes associated with this allele

• Allele Symbol: Fes^tm1Mcs
• Allele Name: targeted mutation 1, M Celeste Simon
• Allele ID: MGI:2182586
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fes^tm1Mcs/Fes^tm1Mcs	involves: 129X1/SvJ	MGI:3844904

Genotype
MGI:3844904

hm1

• Allelic Composition: Fes^tm1Mcs/Fes^tm1Mcs
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:64748 )

• reduced numbers of homozygotes at birth

• no further deaths between birth and weaning

hematopoietic system

thymus hypoplasia ( J:64748 )

• hypocellularity often observed at three weeks of age

abnormal bone marrow cell morphology/development ( J:64748 )

decreased bone marrow cell number ( J:64748 )

• hypocellularity often observed at 3 weeks of age

abnormal megakaryocyte progenitor cell morphology ( J:64748 )

• spleen with a 2 fold increase of CFU-M progenitors

abnormal leukocyte cell number ( J:64748 )

increased granulocyte number ( J:64748 )

• in bone marrow and spleen

increased neutrophil cell number ( J:64748 )

decreased B cell number ( J:64748 )

increased monocyte cell number ( J:64748 )

• elevated 2 fold in spleen and bone marrow

• elevated 7-8 fold in peripheral blood

abnormal macrophage physiology ( J:64748 )

• decreased adhesion of macrophage to extra-cellular matrices

• increased macrophage proliferation in response to GM-CSF

growth/size/body

postnatal growth retardation ( J:64748 )

• three week old mice are often runted, weak, and generally unhealthy

immune system

thymus hypoplasia ( J:64748 )

• hypocellularity often observed at three weeks of age

abnormal leukocyte cell number ( J:64748 )

increased granulocyte number ( J:64748 )

• in bone marrow and spleen

increased neutrophil cell number ( J:64748 )

decreased B cell number ( J:64748 )

increased monocyte cell number ( J:64748 )

• elevated 2 fold in spleen and bone marrow

• elevated 7-8 fold in peripheral blood

abnormal macrophage physiology ( J:64748 )

• decreased adhesion of macrophage to extra-cellular matrices

• increased macrophage proliferation in response to GM-CSF

conjunctivitis ( J:64748 )

• frequently seen in mice 6-10 weeks of age

increased susceptibility to bacterial infection ( J:64748 )

• increased ankle swelling in response to infection with Borrelia burgdorferi

vision/eye

conjunctivitis ( J:64748 )

• frequently seen in mice 6-10 weeks of age

integument

skin lesions ( J:64748 )

• frequently seen in mice 6-10 weeks of age

endocrine/exocrine glands

thymus hypoplasia ( J:64748 )

• hypocellularity often observed at three weeks of age