Analysis Tools
adipose tissue
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• mice exhibit decreased white adipose tissue and perirenal, retroperitoneal, and subcutaneous abdominal fat compared to in wild-type mice
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• brown fat cells from lipodystrophic mice exhibit a reduction in number and size with a corresponding increase in the cytoplasm volume unlike in brown adipose tissue
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• white fat cells from lipodystrophic mice are small, contain small fat vacuoles, and exhibit a 3-fold increase in cell density compared to in normal wild-type white adipose tissue
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lipodystrophy
(
J:73977
)
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• 25% of mice display lipodystrophy
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• release of free fatty acid from epididymal adipose tissue is increased compared to in wild-type mice and not inhibited by the addition of pyruvate
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homeostasis/metabolism
| N |
• mice exhibit normal levels of circulating insulin, and glucose levels
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hyperglycemia
(
J:73977
)
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• moderate after overnight fasting
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• in fed and fasted lipodystrophic mice despite an increase upon fasting
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• in fed and fasted lipodystrophic mice despite an increase upon fasting
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• in lipodystrophic mice
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liver/biliary system
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• in lipodystrophic mice
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