All Phenotypes Nr4a1<tm1Jmi> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr4a1^tm1Jmi/Nr4a1^tm1Jmi	involves: 129S2/SvPas	MGI:3042263
hm2	Nr4a1^tm1Jmi/Nr4a1^tm1Jmi	involves: 129S2/SvPas * C57BL/6	MGI:5829822
cx3	Ifi27^tm1Npm/Ifi27^tm1Npm Nr4a1^tm1Jmi/Nr4a1^tm1Jmi	involves: 129 * C57BL/6 * Swiss Webster	MGI:5582318
cx4	Nr4a1^tm1Jmi/Nr4a1^tm1Jmi Nr4a3^tm1Omc/Nr4a3^tm1Omc	involves: 129S/SvEv * 129S2/SvPas * C57BL/6	MGI:3713721

Allelic Composition	Nr4a1^tm1Jmi/Nr4a1^tm1Jmi
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr4a1^tm1Jmi mutation (3 available); any Nr4a1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased B cell apoptosis ( J:306652 )

• greater survival of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)

• normal survival of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes, anti-immunoglobulin M (anti-IgM) and B cell-activating factor (BAFF)

increased B cell proliferation ( J:306652 )

• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM), with or without B cell-activating factor (BAFF)

• normal proliferation when co-cultured in the presence of LPS, CpG, IL4 or anti-CD40 for 72 hours with congenically marked wild-type CD45.1+ lymphocytes, with or without anti-immunoglobulin M (anti-IgM)

reproductive system

abnormal uterus physiology ( J:205553 )

• change in permeability of uterine vasculature following hormone treatment (E2 + P4) is significantly reduced

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:27227 )

• in homozygous null mice, the adrenal glands and hypothalamic paraventricular nucleus appeared histologically normal relative to wild-type

• overall, homozygous null mice displayed a normal HPA axis structure, normal basal regulation of hypothalamic and pituitary functions, as well as normal adrenocortical steroidogenesis

hematopoietic system

decreased B cell apoptosis ( J:306652 )

• greater survival of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)

• normal survival of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes, anti-immunoglobulin M (anti-IgM) and B cell-activating factor (BAFF)

increased B cell proliferation ( J:306652 )

immune system

immune system phenotype ( J:77686 )

N	• homozygous null mice exhibited a completely normal thymic and peripheral T cell deletion relative to wild-type

decreased B cell apoptosis ( J:306652 )

• greater survival of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)

• normal survival of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes, anti-immunoglobulin M (anti-IgM) and B cell-activating factor (BAFF)

increased B cell proliferation ( J:306652 )

cardiovascular system

abnormal vascular permeability ( J:205553 )

• change in permeability of uterine vasculature following hormone treatment (E2 + P4) is significantly reduced

Allelic Composition	Nr4a1^tm1Jmi/Nr4a1^tm1Jmi
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr4a1^tm1Jmi mutation (3 available); any Nr4a1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased Ly6C low monocyte number ( J:239509 )

• following injection of B16F10 melanoma cells, mice exhibit a loss of Ly6^low monocytes

immune system

decreased Ly6C low monocyte number ( J:239509 )

• following injection of B16F10 melanoma cells, mice exhibit a loss of Ly6^low monocytes

increased susceptibility to endotoxin shock ( J:239509 )

• mice exhibit a higher mortality following administration of high dose LPS (2.5 mg/kg) as compared to controls

neoplasm

increased tumor growth/size ( J:239509 )

• following injection of B16F10 melanoma cells, mice exhibit a higher tumor burden than wild-type controls

Allelic Composition	Ifi27^tm1Npm/Ifi27^tm1Npm Nr4a1^tm1Jmi/Nr4a1^tm1Jmi
Genetic Background	involves: 129 * C57BL/6 * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifi27^tm1Npm mutation (0 available); any Ifi27 mutation (10 available)
Nr4a1^tm1Jmi mutation (3 available); any Nr4a1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:212520 )

N	• mice exhibit normal induced restenosis

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:121903 )

• mice fail to thrive and die between 2 - 4 weeks after birth

neoplasm

increased leukemia incidence ( J:121903 )

• acute myeloid leukemia that is rapidly lethal and transplantable

• perivascular infiltrates are seen in nonhematopoietic tissues including the liver and lung

• disseminated myeloid cells are seen in the spleen and lung

hematopoietic system

abnormal thymus morphology ( J:121903 )

• severe disruption of the architecture at 2 - 3 weeks of age

abnormal common myeloid progenitor cell morphology ( J:121903 )

• significant expansion of myeloid progenitors

abnormal leukopoiesis ( J:121903 )

• immature blasts make up as much as 80% of white blood cells

abnormal myelopoiesis ( J:121903 )

• increase in the number of CD11b+ progenitor cells and these cells display a significant increase in the number of cells in the S and G2/M phases of the cell cycle

anemia ( J:121903 )

• at 2 -3 weeks of age

abnormal bone marrow cell number ( J:121903 )

• reduction in the number of lymphoid and erythroid cells and increase in the number of granulocytes

decreased lymphocyte cell number ( J:121903 )

• marked reduction of the number of lymphoid cells in the spleen, bone marrow, and thymus

increased leukocyte cell number ( J:121903 )

• variable incidence of leukocytosis at 2 -3 weeks of age

• however, all homozygotes show an increase in immature/blast myeloid forms in the bone marrow, spleen, and peripheral blood

increased granulocyte number ( J:121903 )

• marked expansion of granulocytes in the bone marrow, spleen, thymus, and lymph nodes

increased eosinophil cell number ( J:121903 )

• variable incidence of eosinophilia at 2 -3 weeks of age

increased neutrophil cell number ( J:121903 )

• variable incidence of eosinophilia at 2 -3 weeks of age

increased hematopoietic stem cell number ( J:121903 )

• 2.6-fold increase in the number of long term hematopoietic stem cells in bone marrow

• however, the number of short term hematopoietic stem cells is not increased

abnormal spleen morphology ( J:121903 )

• severe disruption of the architecture at 2 - 3 weeks of age

enlarged spleen ( J:121903 )

• at 2 -3 weeks of age

growth/size/body

decreased body size ( J:121903 )

enlarged liver ( J:121903 )

• at 2 -3 weeks of age

enlarged spleen ( J:121903 )

• at 2 -3 weeks of age

behavior/neurological

hunched posture ( J:121903 )

liver/biliary system

enlarged liver ( J:121903 )

• at 2 -3 weeks of age

immune system

abnormal thymus morphology ( J:121903 )

• severe disruption of the architecture at 2 - 3 weeks of age

abnormal leukopoiesis ( J:121903 )

• immature blasts make up as much as 80% of white blood cells

abnormal myelopoiesis ( J:121903 )

• increase in the number of CD11b+ progenitor cells and these cells display a significant increase in the number of cells in the S and G2/M phases of the cell cycle

decreased lymphocyte cell number ( J:121903 )

• marked reduction of the number of lymphoid cells in the spleen, bone marrow, and thymus

increased leukocyte cell number ( J:121903 )

• variable incidence of leukocytosis at 2 -3 weeks of age

• however, all homozygotes show an increase in immature/blast myeloid forms in the bone marrow, spleen, and peripheral blood

increased granulocyte number ( J:121903 )

• marked expansion of granulocytes in the bone marrow, spleen, thymus, and lymph nodes

increased eosinophil cell number ( J:121903 )

• variable incidence of eosinophilia at 2 -3 weeks of age

increased neutrophil cell number ( J:121903 )

• variable incidence of eosinophilia at 2 -3 weeks of age

abnormal spleen morphology ( J:121903 )

• severe disruption of the architecture at 2 - 3 weeks of age

enlarged spleen ( J:121903 )

• at 2 -3 weeks of age

enlarged lymph nodes ( J:121903 )

• at 2 -3 weeks of age

integument

ruffled hair ( J:121903 )

endocrine/exocrine glands

abnormal thymus morphology ( J:121903 )

• severe disruption of the architecture at 2 - 3 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute myeloid leukemia		DOID:9119	OMIM:601626	J:121903

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