Mouse Genome Informatics
hm1
    Lta/Tnftm1Eug/Lta/Tnftm1Eug
B6.129-Lta/Tnftm1Eug
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• most S. aureus-infected mice die unlike similarly treated wild-type mice

immune system
• in S.aureus-infected mice
• in S.aureus-infected mice
• in S.aureus-infected mice
• in S.aureus-infected mice
• in S.aureus-infected mice
• 28 days after S. aureus infection
• from spleen cells of S. aureus-infected mice
• S. aureus-infected mice exhibit decreased septic arthritis compared with similarly treated wild-type mice
• Staphylococcus aureus-infected mice exhibit greater weight loss, increased mortality, reduced bacterial clearance, decreased IFN-gamma production, decreased septic arthritis, increased IgM serum levels, and decreased antigen-specific IgG serum levels compared with similarly treated wild-type mice
• most S. aureus-infected mice die unlike similarly treated wild-type mice

skeleton
• S. aureus-infected mice exhibit decreased septic arthritis compared with similarly treated wild-type mice

homeostasis/metabolism
• 28 days after S. aureus infection

behavior/neurological
• mice exhibit reduced rapid eye movement (REM) sleep episode frequency compared with wild-type mice
• mice exhibit higher absolute electroencephalogram (EEG) power density non-REM sleep within the slow-wave range compared with wild-type mice
• after sleep deprivation, mice exhibit a greater increase in fast 'slow waves' compared with wild-type mice
• however, a decrease in non-REM sleep episode frequency is compensated by extension of non-REM sleep episode duration

hematopoietic system
• in S.aureus-infected mice
• in S.aureus-infected mice
• in S.aureus-infected mice
• in S.aureus-infected mice
• in S.aureus-infected mice


Mouse Genome Informatics
hm2
    Lta/Tnftm1Eug/Lta/Tnftm1Eug
involves: 129/Sv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice survive doses of LPS that are 100 times as much as the dose that would kill a wild-type mouse
• mice cannot control a dose Listeria monocytogenes that is tolerated by wild-type mice and eventually die from listeriosis with high liver and spleen titers and large necrotic lesions with boundaries of heavily infected hepatocytes

immune system
• CD3+ T cells are decreased (25%+/-3% compared to 45%+/-3% in wild-type mice)
• peripheral T cells are decreased 2-fold compared to wild-type
• leukocyte cell number is increased 4-fold compared to wild-type
• 65%+/-4% B220+ B cells compared to 44%+/-2% in wild-type mice
• peripheral B cells are increased 6-fold compared to wild-type
• the T cell zones are lost and the marginal zone is ill-defined
• spleen lymphocyte composition and micro-architecture are altered
• the marginal zone is ill-defined
• mice are unable to mount a primary IgG response to sheep red blood cells
• mice cannot control a dose Listeria monocytogenes that is tolerated by wild-type mice and eventually die from listeriosis with high liver and spleen titers and large necrotic lesions with boundaries of heavily infected hepatocytes
• response to VV-WR infection is slightly reduced and to LCMV-ARM is strongly reduced
• when footpads are infected with LCMV-ARM or LCMV-WE they fail to swell as in wild-type mice

hematopoietic system
• CD3+ T cells are decreased (25%+/-3% compared to 45%+/-3% in wild-type mice)
• peripheral T cells are decreased 2-fold compared to wild-type
• leukocyte cell number is increased 4-fold compared to wild-type
• 65%+/-4% B220+ B cells compared to 44%+/-2% in wild-type mice
• peripheral B cells are increased 6-fold compared to wild-type
• spleen lymphocyte composition and micro-architecture are altered
• the T cell zones are lost and the marginal zone is ill-defined
• the marginal zone is ill-defined


Mouse Genome Informatics
hm3
    Lta/Tnftm1Eug/Lta/Tnftm1Eug
involves: 129/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• following traumatic brain injury, more mice die than similarly treated wild-type mice

immune system
• following treatment with MOG, mice exhibit delayed onset, decreased severity of disease, and reduced demyelination but increased number of inflammatory foci compared with similarly treated wild-type mice
• mice treated with Plasmodium berghei ANKA (PbA)-infected erythrocytes fail to develop cerebral malaria or vascular leakiness unlike similarly treated wild-type mice
• however, mice treated with PbA-infected with erythrocytes exhibit weight loss, anemia, high parasitemia, and die between 15 and 20 days post-infection

homeostasis/metabolism
• following traumatic brain injury, more mice die than similarly treated wild-type mice
• however, traumatic brain injury-induced blood brain barrier disfunction and accumulation of polymononuclear leukocytes is normal


Mouse Genome Informatics
hm4
    Lta/Tnftm1Eug/Lta/Tnftm1Eug
involves: 129 * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size
• when fed a high cholesterol diet
• whether fed standard chow or a high cholesterol diet
• when fed a high cholesterol diet
• when fed a high cholesterol diet

liver/biliary system
• after 12 weeks on a high cholesterol diet
• after 12 weeks on a high cholesterol diet
• after 12 weeks on a high cholesterol diet

skeleton
• when fed a high cholesterol diet

cardiovascular system
• when fed a high cholesterol diet

homeostasis/metabolism
• when fed a high cholesterol diet

immune system
• when fed a high cholesterol diet

limbs/digits/tail
• when fed a high cholesterol diet

hematopoietic system
• when fed a high cholesterol diet