Phenotypes associated with this allele

• Allele Symbol: Vdac1^tm1Wjc
• Allele Name: targeted mutation 1, William J Craigen
• Allele ID: MGI:2182154
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vdac1^tm1Wjc/Vdac1^tm1Wjc	involves: 129S7/SvEvBrd	MGI:2653816
cx2	Vdac1^tm1Wjc/Vdac1^tm1Wjc Vdac3^tm1Wjc/Vdac3^tm1Wjc	involves: 129S7/SvEvBrd	MGI:2653814

Genotype
MGI:2653816

hm1

• Allelic Composition: Vdac1^tm1Wjc/Vdac1^tm1Wjc
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:76838 )

• 40% of the expected numbers are seen, with lethality occurring between E10.5 and E11.5

• remaining mutants survive to adulthood

nervous system

reduced long-term potentiation ( J:76838 )

• long term potentiation, induced with two trains of 100 Hz for 1 s tetani separated by 20 s, is significantly attenuated

behavior/neurological

abnormal cued conditioning behavior ( J:76838 )

• mutants exhibit reduced freezing behavior in response to an auditory cue in a novel context

abnormal spatial learning ( J:76838 )

• on a hidden platform Morris water maze, mutants show greater latency than wild-type in finding the hidden platform by 6 days of training, despite no differences in swimming speed

• in a probe test (removal of platform), mutants do not spend more time in the trained quadrant or cross the trained site as seen in wild-type

Genotype
MGI:2653814

cx2

• Allelic Composition: Vdac1^tm1Wjc/Vdac1^tm1Wjc; Vdac3^tm1Wjc/Vdac3^tm1Wjc
• Genetic Background: involves: 129S7/SvEvBrd

mortality/aging

prenatal lethality, incomplete penetrance ( J:76838 )

• fewer than the expected numbers of double mutants are born; time of lethality not specified

growth/size/body

postnatal growth retardation ( J:76838 )

nervous system

reduced long-term potentiation ( J:76838 )

• long term potentiation, induced with two trains of 100 Hz for 1 s tetani separated by 20 s, is significantly impaired

decreased paired-pulse facilitation ( J:76838 )

• hippocampal slices show a significant reduction in paired-pulse facilitation when the two depolarizations are within 100 ms of each other

behavior/neurological

abnormal contextual conditioning behavior ( J:76838 )

• mutants exhibit reduced contextual freezing behavior when introduced to the training context 24 hours following training, indicating impaired contextual fear conditioning

abnormal cued conditioning behavior ( J:76838 )

• mutants exhibit reduced freezing behavior in response to an auditory cue in a novel context