All Phenotypes Hlx<tm1Rph> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hlx^tm1Rph/Hlx^tm1Rph	FVB.129P2-Hlx^tm1Rph	MGI:3773352
hm2	Hlx^tm1Rph/Hlx^tm1Rph	involves: 129P2/OlaHsd	MGI:3615521
cx3	Hlx^tm1Rph/Hlx^tm1Rph Tg(DBHn-lacZ)8Rpk/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	MGI:3773359

Allelic Composition	Hlx^tm1Rph/Hlx^tm1Rph
Genetic Background	FVB.129P2-Hlx^tm1Rph

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hlx^tm1Rph mutation (2 available); any Hlx mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Hlx^tm1Rph/Hlx^tm1Rph mice at E17.5 are pale, reduced in size and exhibit hydrops

mortality/aging

perinatal lethality, complete penetrance ( J:119681 )

• Background Sensitivity: mutants on the FVB/N background survive longer (embryos are seen through E18.5 and only newborn pups are found dead) than mutants on a 129P2/OlaHsd background (die around E15.5)

growth/size/body

decreased fetal size ( J:119681 )

• late-gestation embryos are small

nervous system

abnormal enteric neuron morphology ( J:119681 )

• marker analysis of the intestinal mesenchyme from E10.5 to E16.5 shows that neural crest cells/early enteric neurons are largely absent in the intestine

liver/biliary system

abnormal liver development ( J:119681 )

• lack hepatic development

homeostasis/metabolism

decreased circulating serum albumin level ( J:119681 )

• decease in serum albumin concentrations

hydrops fetalis ( J:119681 )

• late-gestation embryos exhibit hydrops, with the skin ballooning by subcutaneous fluid

integument

pallor ( J:119681 )

• late-gestation embryos are pale

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:31553 )

• embryos are dead by E15

• defects in organogenesis although embryo size normal

liver/biliary system

absent gallbladder ( J:31553 )

abnormal liver development ( J:31553 )

• liver development starts normally at about E9

• no liver buds formed by E10.5

• at E14.5 liver composed of a small dorsal bud and very rudimentary ventral lobe

• general architecture and cell composition normal at E14.5

• hepatocyte differentiation normal

abnormal liver bud morphology ( J:31553 )

• no liver buds formed by E10.5

liver hypoplasia ( J:31553 )

• liver minute in size at death

• at E12.5 only 3% of normal number of cells

digestive/alimentary system

abnormal intestine morphology ( J:31553 )

• gut appears normal at E10.5

• only a single intestinal loop at E13.5 and E14.5 as opposed to more extensive looping in controls

• intestine only about 1/4 normal length at death

hematopoietic system

abnormal erythropoiesis ( J:31553 )

• erythroid precursors in liver at normal proportions but low absolute numbers

anemia ( J:31553 )

• at E13.5

• embryos pallid at death

impaired hematopoiesis ( J:31553 )

• hematopoietic cells function normally when transplanted

• proportion of multilinear precursors is reduced

• deficient fetal hematopoiesis which occurs in the liver starting around E10

• yolk sac hematopoesis is normal

respiratory system

enlarged lung ( J:31553 )

• appear somewhat enlarged and protrude through the diaphragm

muscle

abnormal diaphragm morphology ( J:31553 )

• contains few muscle cells

diaphragmatic hernia ( J:31553 )

endocrine/exocrine glands

absent gallbladder ( J:31553 )

small pancreas ( J:31553 )

• pancreas reduced in size but otherwise normal