About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(NFH)120Jpj
transgene insertion 120, Jean-Pierre Julien
MGI:2182067
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(NFH)120Jpj/Tg(NFH)120Jpj Not Specified MGI:2183662
tg2
Tg(NFH)120Jpj/0 Not Specified MGI:2183668


Genotype
MGI:2183662
tg1
Allelic
Composition
Tg(NFH)120Jpj/Tg(NFH)120Jpj
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• spinal cord sections revealed many abnormalities in motor neurons of the anterior horn and the dorsal root ganglia, including swelling of perikaraya and proximal axons (J:69180)
• immunofluorescence staining demonstrated that the swelling was the result of heteropolymerization of multiple neurofilament subunits (J:69180)
• spinal cord sections revealed many abnormalities in motor neurons of the anterior horn and the dorsal root ganglia, including swelling of perikaraya and proximal axons (J:69180)
• immunofluorescence staining demonstrated that the swelling was the result of heteropolymerization of multiple neurofilament subunits (J:69180)
• distal axons of the sciatic nerve appear shrunken in caliber with thick myelin sheaths (J:69180)
• distal axons of the sciatic nerve appear shrunken in caliber with thick myelin sheaths (J:69180)

behavior/neurological
• when lifted by the tail, mice contract their forelimbs and hindlimbs, compared to control mice that extend their legs (J:69180)
• when lifted by the tail, mice contract their forelimbs and hindlimbs, compared to control mice that extend their legs (J:69180)
• mice are described as displaying fine tremors by 6 months of age (J:69180)
• mice are described as displaying fine tremors by 6 months of age (J:69180)

muscle
• severely affected mice are unable to support their weight when grasping a pencil (J:69180)
• severely affected mice are unable to support their weight when grasping a pencil (J:69180)

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:69180




Genotype
MGI:2183668
tg2
Allelic
Composition
Tg(NFH)120Jpj/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• spinal cord sections revealed many abnormalities in motor neurons of the anterior horn and the dorsal root ganglia, including swelling of perikaraya and proximal axons (J:69180)
• immunofluorescence staining demonstrated that the swelling was the result of heteropolymerization of multiple neurofilament subunits (J:69180)
• spinal cord sections revealed many abnormalities in motor neurons of the anterior horn and the dorsal root ganglia, including swelling of perikaraya and proximal axons (J:69180)
• immunofluorescence staining demonstrated that the swelling was the result of heteropolymerization of multiple neurofilament subunits (J:69180)
• distal axons of the sciatic nerve appear shrunken in caliber with thick myelin sheaths (J:69180)
• distal axons of the sciatic nerve appear shrunken in caliber with thick myelin sheaths (J:69180)

behavior/neurological
• when lifted by the tail, mice contract their forelimbs and hindlimbs, compared to control mice that extend their legs (J:69180)
• when lifted by the tail, mice contract their forelimbs and hindlimbs, compared to control mice that extend their legs (J:69180)
• mice are described as displaying fine tremors by 6 months of age (J:69180)
• mice are described as displaying fine tremors by 6 months of age (J:69180)

muscle
• severely affected mice are unable to support their weight when grasping a pencil (J:69180)
• severely affected mice are unable to support their weight when grasping a pencil (J:69180)

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:69180





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory