Analysis Tools
nervous system
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• mice exhibit fewer proliferating cells and slowly dividing cells in the adult subventricular zone (SVZ) compared to in wild-type mice
• fewer progenitor cells are found in the adult SVZ compared to in wild-type mice
• however, the number of apoptotic cells in the SVZ is normal
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• mice exhibit more myelinated sensory axons in the dorsal root ganglia than in wild-type mice
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• olfactory axons exhibit abnormal projections in the dorsocaudal olfactory bulb and, unlike in wild-type mice most axons do not terminate in discrete glomeruli
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• mice exhibit more myelinated sensory axons in the dorsal root ganglia than in wild-type mice
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• mice exhibit a delay in eliminating nerve endings after axotomy compared to in wild-type mice
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• mice exhibit fewer IB4-binding neurons (non-peptidergic nociceptor neurons) in the dorsal root ganglia than in wild-type mice
• IB4-binding axons extend deeper into the dorsal horn of the spinal cord than in wild-type mice
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• mice exhibit fewer IB4-binding neurons (non-peptidergic nociceptor neurons), more NF200-exressing neurons (large-diameter mechanoreceptor neurons) and more myelinated sensory axons in the dorsal root ganglia than in wild-type mice
• the mean diameter of neurons in the dorsal root ganglia is reduced compared to in wild-type mice
• however, the total number of neurons in the dorsal root ganglia is normal
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immune system
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• stimulated CD4+ T cells secrete more IFN-gamma than wild-type mice
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• stimulated CD4+ T cells secrete more IL-2 than wild-type mice
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• when treated to induce experimental autoimmune encephalomyelitis, mice exhibit a more severe disease, vigorous splenocyte proliferation, IL-17 and IFN-gamma production and a greater accumulation of MOG35-55-specific TH1 and TH-17 cells compared to in similarly treated wild-type mice
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muscle
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• mice exhibit a delay in muscle development beginning at day 1 through day 7
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behavior/neurological
| N |
• mice exhibit normal gross physical assessment, sensory-motor reflexes, nociception, prepulse inhibition and threshold to acoustic startle, learning, memory and muscle strength
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• in a movement assay, mice take longer to enter the center from the edge compared with wild-type mice
• however, behavior in an open field assay is normal
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• low social dominance
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craniofacial
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• olfactory axons exhibit abnormal projections in the dorsocaudal olfactory bulb and, unlike in wild-type mice most axons do not terminate in discrete glomeruli
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respiratory system
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• olfactory axons exhibit abnormal projections in the dorsocaudal olfactory bulb and, unlike in wild-type mice most axons do not terminate in discrete glomeruli
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taste/olfaction
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• olfactory axons exhibit abnormal projections in the dorsocaudal olfactory bulb and, unlike in wild-type mice most axons do not terminate in discrete glomeruli
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growth/size/body
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• olfactory axons exhibit abnormal projections in the dorsocaudal olfactory bulb and, unlike in wild-type mice most axons do not terminate in discrete glomeruli
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homeostasis/metabolism
| N |
• mice exhibit normal metabolism
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