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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cacnb1tm1Rgg
targeted mutation 1, Ronald G Gregg
MGI:2181804
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cacnb1tm1Rgg/Cacnb1tm1Rgg involves: 129S7/SvEvBrd MGI:2658925
cx2
Cacnb1tm1Rgg/Cacnb1tm1Rgg
Tg(ACTA1-Cacnb1)1Rgg/0
involves: 129S7/SvEvBrd MGI:3843803


Genotype
MGI:2658925
hm1
Allelic
Composition
Cacnb1tm1Rgg/Cacnb1tm1Rgg
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacnb1tm1Rgg mutation (0 available); any Cacnb1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Muscle mass reduction and disorganization of myofibrils in Cacnb1tm1Rgg/Cacnb1tm1Rgg mice

mortality/aging
• die at birth from asphyxia

behavior/neurological
• fetuses fail to show any movement
• fetuses have flexed necks and extremities

limbs/digits/tail

muscle
• muscle contains myofibrils with well-defined Z-bands but the thick and thin filaments are disorganized
• in isolated myotubes, action potentials are normal but fail to elicit a calcium-transient
• L-type calcium current is decreased 10- to 20-fold in intercostals myotubes
• electrical field stimulation of E16 muscle fails to induce twitches, however contractures are induced by caffeine, although the force produced by the forelimb is reduced 20-30 fold, indicating a lack of excitation-contraction coupling

skeleton
• fetuses exhibit curvature of the spine




Genotype
MGI:3843803
cx2
Allelic
Composition
Cacnb1tm1Rgg/Cacnb1tm1Rgg
Tg(ACTA1-Cacnb1)1Rgg/0
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacnb1tm1Rgg mutation (0 available); any Cacnb1 mutation (12 available)
Tg(ACTA1-Cacnb1)1Rgg mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• both a- and b-waves appear normal in mutant mice (J:80080)
• histological analysis indicates that retinal morphology is normal (J:80080)
• mice exhibit normal electroretinograms (J:136113)





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory