mortality/aging
|
• 50% mortality by 40 weeks of age
|
growth/size
|
• smaller size persists through adulthood
|
|
• 20% growth reduction in males and 18% reduction in females from birth to 45 days of age
|
tumorigenesis
|
• mice dying after 40 weeks of age usually have tumors that are not thymic lymphomas
|
|
• found in all mice dying before 40 weeks
• diverse cell types involved
• spongy tumors with a high proportion of cells undergoing apoptosis
|
immune system
|
• occasional increase in thymocyte size
|
|
• lymph node T cells are primarily at early stages of development
|
|
• 10% reduction in thymocytes
• 30-50% reduction in thymocytes expressing alpha and beta T cell receptors or CD3
|
|
• occurs at random
|
|
• randomly observed increases in single positive T cells
|
|
• usually found in mice dying after 40 weeks of age
|
small spleen
(
J:69726
)
|
• in mice under 40 weeks of age
|
small thymus
(
J:69726
)
cellular
|
• 3 fold increase in radiation induced chromosomal aberrations
|
|
• increased sensitivity of thymocytes and splenocytes to ionizing radiation
|
|
• lymph node T cells are primarily at early stages of development
|
|
• 10% reduction in thymocytes
• 30-50% reduction in thymocytes expressing alpha and beta T cell receptors or CD3
|
|
• occurs at random
|
reproductive system
 |
• tubules disrupted
(J:69726)
|
|
|
• poorly developed
(J:69726)
|
 |
• disrupted
(J:69726)
• lack of maturing follicles and oocytes
(J:69726)
|
|
|
• disrupted spermatogenesis
(J:69726)
|
|
|
• loss of spermatids
(J:69726)
|
|
|
• degenerating spermatocytes
(J:69726)
|
nervous system
| N |
• no gross neuronal degeneration at time points between 2 and 16 months of age
(J:69726)
|
|
• survival of Purkinje cells in culture less than 60% of controls at 4 days and about 40% at 10 day
• survival of cultured cells improves if cultured with cerebellar astroglial cells
• develop simpler dendritic arboritization with reduced secondary branching
• nitroxide free radicals improve survival and arborization
|
endocrine/exocrine glands
|
|
• tubules disrupted
(J:69726)
|
|
|
• poorly developed
(J:69726)
|
hematopoietic system
|
• lymph node T cells are primarily at early stages of development
|
|
• 10% reduction in thymocytes
• 30-50% reduction in thymocytes expressing alpha and beta T cell receptors or CD3
|
|
• occurs at random
|
|
• randomly observed increases in single positive T cells
|
|
• usually found in mice dying after 40 weeks of age
|
small spleen
(
J:69726
)
|
• in mice under 40 weeks of age
|
small thymus
(
J:69726
)
Mouse Models of Human Disease |
OMIM ID | Ref(s) | |
| Ataxia-Telangiectasia; AT | 208900 | J:69726 | |