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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atmtm1Mfl
targeted mutation 1, Martin F Lavin
MGI:2181756
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Atmtm1Mfl/Atmtm1Mfl involves: 129T2/SvEms * C57BL/6J MGI:2181774
ht2
Atmtm1Mfl/Atm+ involves: 129T2/SvEms * C57BL/6J MGI:3702914


Genotype
MGI:2181774
hm1
Allelic
Composition
Atmtm1Mfl/Atmtm1Mfl
Genetic
Background
involves: 129T2/SvEms * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Mfl mutation (1 available); any Atm mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% mortality by 40 weeks of age (J:69726)
• 50% mortality by 40 weeks of age (J:69726)

growth/size/body
• smaller size persists through adulthood (J:69726)
• smaller size persists through adulthood (J:69726)
• 20% growth reduction in males and 18% reduction in females from birth to 45 days of age (J:69726)
• 20% growth reduction in males and 18% reduction in females from birth to 45 days of age (J:69726)

tumorigenesis
• mice dying after 40 weeks of age usually have tumors that are not thymic lymphomas (J:69726)
• mice dying after 40 weeks of age usually have tumors that are not thymic lymphomas (J:69726)
• found in all mice dying before 40 weeks (J:69726)
• diverse cell types involved (J:69726)
• spongy tumors with a high proportion of cells undergoing apoptosis (J:69726)
• found in all mice dying before 40 weeks (J:69726)
• diverse cell types involved (J:69726)
• spongy tumors with a high proportion of cells undergoing apoptosis (J:69726)

immune system
• occasional increase in thymocyte size (J:69726)
• occasional increase in thymocyte size (J:69726)
• lymph node T cells are primarily at early stages of development (J:69726)
• lymph node T cells are primarily at early stages of development (J:69726)
• occurs at random (J:69726)
• occurs at random (J:69726)
• randomly observed increases in single positive T cells (J:69726)
• randomly observed increases in single positive T cells (J:69726)
• 10% reduction in thymocytes (J:69726)
• 30-50% reduction in thymocytes expressing alpha and beta T cell receptors or CD3 (J:69726)
• 10% reduction in thymocytes (J:69726)
• 30-50% reduction in thymocytes expressing alpha and beta T cell receptors or CD3 (J:69726)
• usually found in mice dying after 40 weeks of age (J:69726)
• usually found in mice dying after 40 weeks of age (J:69726)
• in mice under 40 weeks of age (J:69726)
• in mice under 40 weeks of age (J:69726)

cellular
• 3 fold increase in radiation induced chromosomal aberrations (J:69726)
• 3 fold increase in radiation induced chromosomal aberrations (J:69726)
• increased sensitivity of thymocytes and splenocytes to ionizing radiation (J:69726)
• increased sensitivity of thymocytes and splenocytes to ionizing radiation (J:69726)

reproductive system
• tubules disrupted (J:69726)
• tubules disrupted (J:69726)
• poorly developed (J:69726)
• poorly developed (J:69726)
• disrupted (J:69726)
• lack of maturing follicles and oocytes (J:69726)
• disrupted (J:69726)
• lack of maturing follicles and oocytes (J:69726)
• disrupted spermatogenesis (J:69726)
• disrupted spermatogenesis (J:69726)
• loss of spermatids (J:69726)
• loss of spermatids (J:69726)
• degenerating spermatocytes (J:69726)
• degenerating spermatocytes (J:69726)

nervous system
N
• no gross neuronal degeneration at time points between 2 and 16 months of age (J:69726)
• no gross neuronal degeneration at time points between 2 and 16 months of age (J:69726)
• survival of Purkinje cells in culture less than 60% of controls at 4 days and about 40% at 10 day (J:86894)
• survival of cultured cells improves if cultured with cerebellar astroglial cells (J:86894)
• develop simpler dendritic arboritization with reduced secondary branching (J:86894)
• nitroxide free radicals improve survival and arborization (J:86894)
• survival of Purkinje cells in culture less than 60% of controls at 4 days and about 40% at 10 day (J:86894)
• survival of cultured cells improves if cultured with cerebellar astroglial cells (J:86894)
• develop simpler dendritic arboritization with reduced secondary branching (J:86894)
• nitroxide free radicals improve survival and arborization (J:86894)

endocrine/exocrine glands
• 10% reduction in thymocytes (J:69726)
• 30-50% reduction in thymocytes expressing alpha and beta T cell receptors or CD3 (J:69726)
• 10% reduction in thymocytes (J:69726)
• 30-50% reduction in thymocytes expressing alpha and beta T cell receptors or CD3 (J:69726)
• tubules disrupted (J:69726)
• tubules disrupted (J:69726)
• poorly developed (J:69726)
• poorly developed (J:69726)

hematopoietic system
• 10% reduction in thymocytes (J:69726)
• 30-50% reduction in thymocytes expressing alpha and beta T cell receptors or CD3 (J:69726)
• 10% reduction in thymocytes (J:69726)
• 30-50% reduction in thymocytes expressing alpha and beta T cell receptors or CD3 (J:69726)
• lymph node T cells are primarily at early stages of development (J:69726)
• lymph node T cells are primarily at early stages of development (J:69726)
• occurs at random (J:69726)
• occurs at random (J:69726)
• randomly observed increases in single positive T cells (J:69726)
• randomly observed increases in single positive T cells (J:69726)
• usually found in mice dying after 40 weeks of age (J:69726)
• usually found in mice dying after 40 weeks of age (J:69726)
• in mice under 40 weeks of age (J:69726)
• in mice under 40 weeks of age (J:69726)

Mouse Models of Human Disease
OMIM ID Ref(s)
Ataxia-Telangiectasia; AT 208900 J:69726




Genotype
MGI:3702914
ht2
Allelic
Composition
Atmtm1Mfl/Atm+
Genetic
Background
involves: 129T2/SvEms * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Mfl mutation (1 available); any Atm mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• elevated tumor incidence (J:78527)
• average age at onset 18.6 months (J:78527)
• varying tumor types including dermatoid cysts (J:78527)
• elevated tumor incidence (J:78527)
• average age at onset 18.6 months (J:78527)
• varying tumor types including dermatoid cysts (J:78527)
• 13% of total (J:78527)
• 13% of total (J:78527)
• 5% of total (J:78527)
• 5% of total (J:78527)
• 24% of total (J:78527)
• 24% of total (J:78527)
• 32% of total (J:78527)
• half of sarcomas are in Mammary glands (J:78527)
• 32% of total (J:78527)
• half of sarcomas are in Mammary glands (J:78527)
• 8% of total (J:78527)
• 8% of total (J:78527)





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory