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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc2a2tm1Thor
targeted mutation 1, Bernard Thorens
MGI:2181752
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc2a2tm1Thor/Slc2a2tm1Thor involves: 129P2/OlaHsd * C57BL/6J MGI:3029380
cx2
Slc2a2tm1Thor/Slc2a2tm1Thor
Tg(Ins1-SLC2A1)1Thor/0
involves: 129P2/OlaHsd * C57BL/6 MGI:4818917
cx3
Slc2a2tm1Thor/Slc2a2+
Tg(Ins1-SLC2A1)1Thor/0
involves: 129P2/OlaHsd * C57BL/6 MGI:4818918


Genotype
MGI:3029380
hm1
Allelic
Composition
Slc2a2tm1Thor/Slc2a2tm1Thor
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc2a2tm1Thor mutation (0 available); any Slc2a2 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• died at 2-3 weeks of age

endocrine/exocrine glands
• volume density increased 50% as glucagon expression increased
• volume density of beta cells decreased 30%
• pancreas weight dropped about 25% by day 15

growth/size/body
• growth was normal for first 6 days
• failed to thrive thereafter
• body weight down 35% by day 15

homeostasis/metabolism
• blood osmolality increased to 420 mosmol/l
• moderately hyperglycemic at day 15
• glucagons levels were markedly increased at 15 days of age
• relatively hypoinsulinemic at day 15
• glucose stimulated insulin secretion did not occur
• no buildup of insulin mRNA in beta cells
• in an oral glucose tolerance test, a sharp rise in glucose occurred
• hyperglycemia persisted longer than in controls
• basal glucose levels were elevated




Genotype
MGI:4818917
cx2
Allelic
Composition
Slc2a2tm1Thor/Slc2a2tm1Thor
Tg(Ins1-SLC2A1)1Thor/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc2a2tm1Thor mutation (0 available); any Slc2a2 mutation (31 available)
Tg(Ins1-SLC2A1)1Thor mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• expression of transgene prevents early lethality observed in Slc2a2tm1Thor homozygous non-transgenic mice

growth/size/body
N
• body weight and composition are identical to wild-type controls at 12-16 weeks

homeostasis/metabolism
• during 24 h of food deprivation, body temperature decreases significantly compared to wild-type controls at end of dark period as mice enter torpor
• when exposed continuously to low temperature (4 degrees C), mutants show reduced ability to regulate and maintain body temperature compared to controls
• when mice are deprived of food for 6 h and receive intracerebroventricular injections of 2-deoxyglucose (0.5 mg, 1.5 mg or 2.5 mg), no significant decrease in body temperature is observed compared to wild-type controls at the lowest dose after 2 hours; at the median dose, a significant difference is seen at 2 hours but is less significant than controls; at the highest dose, temperature decrease is similar to that observed in controls

behavior/neurological
• at end of dark period, mutants show less locomotor acitivity compared to controls as they enter torpor during 24 h of food deprivation
• when exposed continuously to low temperature (4 degrees C), mutants and wild-type controls display similar locomotor activity




Genotype
MGI:4818918
cx3
Allelic
Composition
Slc2a2tm1Thor/Slc2a2+
Tg(Ins1-SLC2A1)1Thor/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc2a2tm1Thor mutation (0 available); any Slc2a2 mutation (31 available)
Tg(Ins1-SLC2A1)1Thor mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
N
• body weight and composition are identical to controls at 12-16 weeks

homeostasis/metabolism
N
• during 24 h of food deprivation, body temperature is similar to wild-type controls and does not drop as significantly as Slc2a2 homozygous transgenics
• responses to intracerebroventricular injections of 2-deoxyglucose (0.5 mg, 1.5 mg or 2.5 mg) are similar to controls

behavior/neurological
N
• during 24 h of food deprivation, locomotor activity remains similar to wild-type controls





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory