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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rom1tm1Mci
targeted mutation 1, Roderick R McInnes
MGI:2181662
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rom1tm1Mci/Rom1tm1Mci involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3038629


Genotype
MGI:3038629
hm1
Allelic
Composition
Rom1tm1Mci/Rom1tm1Mci
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rom1tm1Mci mutation (1 available); any Rom1 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• rod outer segments are moderately disorganized at 1 month of age
• by 2 months of age there is a loss of parallel arrangement and gaps filled with amorphous material appear between outer segments
• there is a mixture of normal outer segments juxtaposed to others distorted with membranous whorls and large interdisk gaps
• rod outer segment organization improves somewhat after 4 months of age
• disks frequently have increased diameters; mean diameter is increased by 39%
• outer segment length is about 23% less than in control mice
• this is the result of a failure to increase in length between 1 and 2 months rather than progressive degeneration
• rod photoreceptors apoptose although the rate of loss is slow
• the number of cone receptors is unchanged at 18 months of age
• outer nuclear layer becomes progressively thinner after 2 months of age
• maximal rod photoreceptor response is 50% lower at 9 months than in age matched controls

nervous system
• rod outer segments are moderately disorganized at 1 month of age
• by 2 months of age there is a loss of parallel arrangement and gaps filled with amorphous material appear between outer segments
• there is a mixture of normal outer segments juxtaposed to others distorted with membranous whorls and large interdisk gaps
• rod outer segment organization improves somewhat after 4 months of age
• disks frequently have increased diameters; mean diameter is increased by 39%
• outer segment length is about 23% less than in control mice
• this is the result of a failure to increase in length between 1 and 2 months rather than progressive degeneration
• rod photoreceptors apoptose although the rate of loss is slow
• the number of cone receptors is unchanged at 18 months of age





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory