About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hprttm1(CAG-cre)Mnn
targeted mutation 1, Jeffrey R Mann
MGI:2181632
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Hoxa5tm1.1Mrc/Hoxa5+
Hoxb5tm2.1Mrc/Hoxb5+
Hprttm1(CAG-cre)Mnn/Y
involves: 129S1/Sv MGI:3719824
cn2
Hprttm1(CAG-cre)Mnn/Hprt+
Ptpn11tm1Ckq/Ptpn11+
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J MGI:5295464
cn3
Ext1tm1Vcs/Ext1+
Hprttm1(CAG-cre)Mnn/Hprt+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4437603
cn4
Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc
Hprttm1(CAG-cre)Mnn/Hprttm1(CAG-cre)Mnn
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3711003
cn5
Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc
Hprttm1(CAG-cre)Mnn/Hprttm1(CAG-cre)Mnn
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3711002
cn6
Porcntm1.1Vdv/Porcn+
Hprttm1(CAG-cre)Mnn/Hprt+
involves: 129S/Sv * C57BL/6J MGI:5435565
cx7
Mcoln3tm1.2Hels/Mcoln3tm1.2Hels
Hprttm1(CAG-cre)Mnn/?
involves: 129X1/SvJ * C57BL/6 * FVB/N MGI:4880691


Genotype
MGI:3719824
cn1
Allelic
Composition
Hoxa5tm1.1Mrc/Hoxa5+
Hoxb5tm2.1Mrc/Hoxb5+
Hprttm1(CAG-cre)Mnn/Y
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5tm1.1Mrc mutation (0 available); any Hoxa5 mutation (18 available)
Hoxb5tm2.1Mrc mutation (0 available); any Hoxb5 mutation (9 available)
Hprttm1(CAG-cre)Mnn mutation (1 available); any Hprt mutation (1274 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed
• mice were used to generate reciprocol translocations




Genotype
MGI:5295464
cn2
Allelic
Composition
Hprttm1(CAG-cre)Mnn/Hprt+
Ptpn11tm1Ckq/Ptpn11+
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprttm1(CAG-cre)Mnn mutation (1 available); any Hprt mutation (1274 available)
Ptpn11tm1Ckq mutation (0 available); any Ptpn11 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Embryonic lethality in Ptpn11tm1Ckq/Ptpn11+ Hprttm1(CAG-cre)Mnn/Hprt+ mice

mortality/aging

embryo

cardiovascular system

craniofacial

growth/size/body




Genotype
MGI:4437603
cn3
Allelic
Composition
Ext1tm1Vcs/Ext1+
Hprttm1(CAG-cre)Mnn/Hprt+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ext1tm1Vcs mutation (1 available); any Ext1 mutation (47 available)
Hprttm1(CAG-cre)Mnn mutation (1 available); any Hprt mutation (1274 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no viable embryos are recovered at E11.5




Genotype
MGI:3711003
cn4
Allelic
Composition
Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc
Hprttm1(CAG-cre)Mnn/Hprttm1(CAG-cre)Mnn
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(SS18)Mrc mutation (0 available); any Gt(ROSA)26Sor mutation (745 available)
Hprttm1(CAG-cre)Mnn mutation (1 available); any Hprt mutation (1274 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no pups were recovered




Genotype
MGI:3711002
cn5
Allelic
Composition
Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc
Hprttm1(CAG-cre)Mnn/Hprttm1(CAG-cre)Mnn
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(SS18/EGFP)Mrc mutation (0 available); any Gt(ROSA)26Sor mutation (745 available)
Hprttm1(CAG-cre)Mnn mutation (1 available); any Hprt mutation (1274 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no pups were recovered

embryo
• at E8.5, embryonic tissue is highly disorganized




Genotype
MGI:5435565
cn6
Allelic
Composition
Porcntm1.1Vdv/Porcn+
Hprttm1(CAG-cre)Mnn/Hprt+
Genetic
Background
involves: 129S/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprttm1(CAG-cre)Mnn mutation (1 available); any Hprt mutation (1274 available)
Porcntm1.1Vdv mutation (1 available); any Porcn mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Open neural tube and abdominal wall closure defect in Porcntm1.1Vdv/Porcn+ Hprttm1(CAG-cre)Mnn/Hprt+ mice

mortality/aging

embryo
• axial/tail truncation in most embryos
• become progressively smaller compared to wild-type controls
• in most embryos

growth/size/body
• become progressively smaller compared to wild-type controls
• defects in ventral body wall closure in most embryos

nervous system
• in most embryos

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
focal dermal hypoplasia DOID:2120 OMIM:305600
J:186934




Genotype
MGI:4880691
cx7
Allelic
Composition
Mcoln3tm1.2Hels/Mcoln3tm1.2Hels
Hprttm1(CAG-cre)Mnn/?
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprttm1(CAG-cre)Mnn mutation (1 available); any Hprt mutation (1274 available)
Mcoln3tm1.2Hels mutation (0 available); any Mcoln3 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• mice exhibit normal breeding

hearing/vestibular/ear
N
• mice exhibit normal hearing and vestibular function





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/18/2022
MGI 6.17
The Jackson Laboratory