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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Stat5btm1Hwd
targeted mutation 1, Helen W Davey
MGI:2181592
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Stat5btm1Hwd/Stat5btm1Hwd involves: 129 * BALB/c MGI:3688439
hm2
Stat5btm1Hwd/Stat5btm1Hwd involves: C57BL/6 MGI:3688423
cx3
Akr1c18tm1Jni/Akr1c18tm1Jni
Stat5btm1Hwd/Stat5btm1Hwd
involves: 129P2/OlaHsd * C57BL/6 MGI:3527341


Genotype
MGI:3688439
hm1
Allelic
Composition
Stat5btm1Hwd/Stat5btm1Hwd
Genetic
Background
involves: 129 * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5btm1Hwd mutation (1 available); any Stat5b mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• both males and females exhibit less adipose tissue
• weight of sublumbar adipose tissue in females is reduced to 36% of wild-type and to 69% of wild-type in males

endocrine/exocrine glands
• mammary gland development is impaired although milk proteins are expressed
• produce insufficient milk to feed pups

growth/size/body
• males, but not females, show decreased body weight so that by 4-5 weeks of age, males are 27% lighter than wild-type and this difference persists beyond puberty
• obesity becomes apparent in some mutants beginning at about 9 weeks of age, showing large testicular fat pads and greater amounts of abdominal fat
• seen in some homozygotes

homeostasis/metabolism
• plasma IGF-1 concentrations are lower in both males and females
• males, but not females, exhibit normal to elevated plasma growth hormone levels
• MUP, a family of alpha2-microglobulin-related liver secretory proteins that comprise a major protein component of mouse urine, levels in male urine are similar to the amounts seen in female urine which is less than seen in wild-type males

liver/biliary system
• seen in some homozygotes
• seen in some homozygotes
• male-specific liver gene expression is decreased to wild-type female levels in homozygous males, while female-predominant liver gene products are increased in males to a level intermediate between wild-type male and female levels

renal/urinary system
• MUP, a family of alpha2-microglobulin-related liver secretory proteins that comprise a major protein component of mouse urine, levels in male urine are similar to the amounts seen in female urine which is less than seen in wild-type males

reproductive system
• females consistently abort between day 8 and 17 of pregnancy, with no obvious maternal, placental or fetal defects; deaths are not associated with genotype of pups
• subcutaneous administration of progesterone maintains pregnancy

integument
• mammary gland development is impaired although milk proteins are expressed
• produce insufficient milk to feed pups
• exhibit a delay of at least 2 weeks in the commencement of second-generation hair growth
• seen in some homozygotes




Genotype
MGI:3688423
hm2
Allelic
Composition
Stat5btm1Hwd/Stat5btm1Hwd
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5btm1Hwd mutation (1 available); any Stat5b mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• splenocytes exhibit greatly diminished proliferation in response to IL-2 and IL-15 and a combination of PMA and IL-4

immune system
• splenocytes exhibit greatly diminished proliferation in response to IL-2 and IL-15 and a combination of PMA and IL-4
• among the double negative cells, there is a moderate decrease in the percentage of CD44+CD25- cells and an increase in the percentage of CD44-CD25+ cells
• the T/B cell ratio is slightly decreased
• thymocyte numbers are modestly diminished
• percentage of NK (CD3-DX5+) cells is diminished (about 55% of the percentage seen in wild-type)
• exhibit a decrease in IL2-Rbeta+ NK cells
• exhibit diminished numbers of single positive splenocytes; the number of CD4-CD8+ splenocytes is reduced, whereas, the number of CD4+CD8- cells is only slightly affected
• exhibit decreased numbers of splenocytes in the periphery
• NK cytolytic activity is impaired

hematopoietic system
• splenocytes exhibit greatly diminished proliferation in response to IL-2 and IL-15 and a combination of PMA and IL-4
• among the double negative cells, there is a moderate decrease in the percentage of CD44+CD25- cells and an increase in the percentage of CD44-CD25+ cells
• the T/B cell ratio is slightly decreased
• thymocyte numbers are modestly diminished
• percentage of NK (CD3-DX5+) cells is diminished (about 55% of the percentage seen in wild-type)
• exhibit a decrease in IL2-Rbeta+ NK cells
• exhibit diminished numbers of single positive splenocytes; the number of CD4-CD8+ splenocytes is reduced, whereas, the number of CD4+CD8- cells is only slightly affected
• exhibit decreased numbers of splenocytes in the periphery
• NK cytolytic activity is impaired

endocrine/exocrine glands
• thymocyte numbers are modestly diminished




Genotype
MGI:3527341
cx3
Allelic
Composition
Akr1c18tm1Jni/Akr1c18tm1Jni
Stat5btm1Hwd/Stat5btm1Hwd
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akr1c18tm1Jni mutation (0 available); any Akr1c18 mutation (22 available)
Stat5btm1Hwd mutation (1 available); any Stat5b mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• corrected mid gestation abortion of embryos seen in Stat5btm1Hwd homozygotes





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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory