pigmentation
|
• 3 out of 4 homozygotes were albino
|
vision/eye
|
• after being kept in constant light for more than 20 days less loss of photoreceptors occurred than in albino controls
• after 60 days in constant light the number of nuclei in the outer nuclear layer was reduced but still more than 4X that of albino controls
|
|
• did not occur in albino mice maintained in a normal light cycle unlike albino controls
• photoreceptor nuclei in the outer nuclear layer remainder normal unlike albino controls where the number is reduced
|
|
• regeneration of bleached rhodopsin required 18-24 hours as opposed to a more normal 1.5 hours
• little restoration of dark adaptation occurred in the 3 hours which was adequate for control mice
• cone recovery after bleaching was delayed by a factor of 2 relative to controls
|
nervous system
|
• after being kept in constant light for more than 20 days less loss of photoreceptors occurred than in albino controls
• after 60 days in constant light the number of nuclei in the outer nuclear layer was reduced but still more than 4X that of albino controls
|
integument
|
• 3 out of 4 homozygotes were albino
|
Mouse Models of Human Disease |
OMIM ID | Ref(s) | |
| Bothnia Retinal Dystrophy | 607475 | J:68444 | |
