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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fgfr1tm3.1Cxd
targeted mutation 3.1, Chu-Xia Deng
MGI:2181473
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fgfr1tm3.1Cxd/Fgfr1tm3.1Cxd involves: 129S6/SvEvTac * Black Swiss MGI:2181546
cn2
Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S6/SvEvTac MGI:3607119
cn3
Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd
Tg(T-cre)1Lwd/0
involves: 129S6/SvEvTac * C3H * C57BL/6 MGI:3607121


Genotype
MGI:2181546
hm1
Allelic
Composition
Fgfr1tm3.1Cxd/Fgfr1tm3.1Cxd
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm3.1Cxd mutation (0 available); any Fgfr1 mutation (221 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3607119
cn2
Allelic
Composition
Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm3.1Cxd mutation (0 available); any Fgfr1 mutation (221 available)
Fgfr1tm3.2Cxd mutation (0 available); any Fgfr1 mutation (221 available)
Shhtm1(EGFP/cre)Cjt mutation (1 available); any Shh mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• at E18.5 a single digit (probably digit 3) is absent on autopods of both the fore and hindlimbs
• at E11.5, limb bud size is normal but only 4 digit condensations are present and the 2 middle condensations are farther apart than normal




Genotype
MGI:3607121
cn3
Allelic
Composition
Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd
Tg(T-cre)1Lwd/0
Genetic
Background
involves: 129S6/SvEvTac * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm3.1Cxd mutation (0 available); any Fgfr1 mutation (221 available)
Fgfr1tm3.2Cxd mutation (0 available); any Fgfr1 mutation (221 available)
Tg(T-cre)1Lwd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• at E10.0, in the forelimb bud the apical ectodermal ridge is wider along the dorsal ventral axis and at E10.5 shorter along the anterior posterior axis
• at E10 the forelimb bud is shorter along the proximal distal axis, wider along the anterior posterior axis and thicker on the dorsal ventral axis and this differences are increased at E10.5
• at E11.5 individual digit condensations cannot be identified
• the number of cells in the forelimb bud is increased 65% and 31% at E10.0 and E10.5, respectively, but decreased by 26% at E11.5 and cell death is increased starting at E10.5 although still confined to the normal cell death domain
• at E9.5 the open neural plate is expanded
• somite size is irregular

limbs/digits/tail
• at E10.0, in the forelimb bud the apical ectodermal ridge is wider along the dorsal ventral axis and at E10.5 shorter along the anterior posterior axis
• at E10 the forelimb bud is shorter along the proximal distal axis, wider along the anterior posterior axis and thicker on the dorsal ventral axis and this differences are increased at E10.5
• at E11.5 individual digit condensations cannot be identified
• the number of cells in the forelimb bud is increased 65% and 31% at E10.0 and E10.5, respectively, but decreased by 26% at E11.5 and cell death is increased starting at E10.5 although still confined to the normal cell death domain
• the forelimb autopod has only 3 digits 1 with 3 phalanges and 2 with 2 phalanges
• at E17.5, the stylopod is shortened by about 15%
• at E17.5, the zeugopod is reduced by about 12% and often fused at the distal end
• the hindlimb is more severely affected than the forelimb

nervous system
• at E9.5 the open neural plate is expanded

skeleton
• at E17.5 the initial cartilage condensations in the forelimb are reduced in number and size





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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory