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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Socs3tm1Jni
targeted mutation 1, James N Ihle
MGI:2181439
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Socs3tm1Jni/Socs3tm1Jni involves: 129P2/OlaHsd MGI:3783722
hm2
Socs3tm1Jni/Socs3tm1Jni involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3783726
ht3
Socs3tm1Jni/Socs3+ B6.129P2-Socs3tm1Jni MGI:3783734
ht4
Socs3tm1Jni/Socs3+ involves: 129P2/OlaHsd MGI:3783730
ht5
Socs3tm1Jni/Socs3+ involves: 129P2/OlaHsd * C57BL/6 MGI:3783733


Genotype
MGI:3783722
hm1
Allelic
Composition
Socs3tm1Jni/Socs3tm1Jni
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs3tm1Jni mutation (0 available); any Socs3 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice continue to die through E16.5 when only 1 is recovered
• mice exhibit embryonic lethality beginning at E12

hematopoietic system
N
• despite disruptions in embryonic erythropoiesis, adult hematopoiesis is normal in irradiated mice reconstituted with Socs3tm1Jni cells
• embryos exhibit a shift from more immature populations to more mature, non-proliferative populations of erythroid cells
• in a colony-forming assay, the number of erythroid colony-forming cells, burst-forming cells and IL-3 sensitive multilineage progenitors is decreased 10-fold compared to wild-type while colony size is typically 5 to 10 times larger than colonies from wild type mice
• at E12.5, mice exhibit erythrocytosis that increases in frequency with age
• most erythrocytes are still nucleated unlike in wild-type mice

liver/biliary system
• at E12.5, the fetal liver is distorted with an excess of erythroid cells

embryo
• embryos exhibit a shift from more immature populations to more mature, non-proliferative populations of erythroid cells
• in a colony-forming assay, the number of erythroid colony-forming cells, burst-forming cells and IL-3 sensitive multilineage progenitors is decreased 10-fold compared to wild-type while colony size is typically 5 to 10 times larger than colonies from wild type mice

growth/size/body

integument
• mice exhibit erythmia throughout the embryo including the head and lens of the eye




Genotype
MGI:3783726
hm2
Allelic
Composition
Socs3tm1Jni/Socs3tm1Jni
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs3tm1Jni mutation (0 available); any Socs3 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• giant cells occupy the labyrinth and there is no labyrinthine layers unlike in wild-type mice




Genotype
MGI:3783734
ht3
Allelic
Composition
Socs3tm1Jni/Socs3+
Genetic
Background
B6.129P2-Socs3tm1Jni
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs3tm1Jni mutation (0 available); any Socs3 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice exhibit improved glucose tolerance compared to wild-type mice when fed a high fat diet
• on a regular or high fat diet

growth/size/body




Genotype
MGI:3783730
ht4
Allelic
Composition
Socs3tm1Jni/Socs3+
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs3tm1Jni mutation (0 available); any Socs3 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• CD-28 mediated IL-2 production is 2-fold higher than in wild-type cells
• however, TCR-mediated IL-2 production is normal




Genotype
MGI:3783733
ht5
Allelic
Composition
Socs3tm1Jni/Socs3+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs3tm1Jni mutation (0 available); any Socs3 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• when placed on a high fat diet mice do not exhibit an increase in leptin levels compared to wild-type mice

growth/size/body
• unlike wild-type mice, treatment with leptin results in weight loss despite equivalent leptin serum levels

adipose tissue
• when treated with leptin





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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory