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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pla2g4atm1Jvb
targeted mutation 1, Joseph V Bonventre
MGI:2181427
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pla2g4atm1Jvb/Pla2g4atm1Jvb involves: 129S4/SvJae MGI:4358749
hm2
Pla2g4atm1Jvb/Pla2g4atm1Jvb involves: 129S4/SvJae * BALB/c MGI:4358877
hm3
Pla2g4atm1Jvb/Pla2g4atm1Jvb involves: 129S4/SvJae * C57BL/6 MGI:4358789
hm4
Pla2g4atm1Jvb/Pla2g4atm1Jvb involves: 129S4/SvJae * C57BL/6J MGI:4358796
cx5
ApcMin/Apc+
Pla2g4atm1Jvb/Pla2g4atm1Jvb
B6.Cg-Pla2g4atm1Jvb ApcMin MGI:4358774
cx6
Pla2g4atm1Jvb/Pla2g4a+
Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:4358899
cx7
Pla2g4atm1Jvb/Pla2g4atm1Jvb
Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:4358900


Genotype
MGI:4358749
hm1
Allelic
Composition
Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g4atm1Jvb mutation (0 available); any Pla2g4a mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• female mice produce fewer, smaller litters that often result in dead pups
• female mice produce fewer, smaller litters that often result in dead pups
• litter size of female mice is decreased regardless of the parental genotype

nervous system
• mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exhibit reduced neuronal cell death compared with similarly treated wild-type mice
• after occlusion of the middle cerebral artery with a transluminal filament and reperfusion, mice exhibit reduced brain edema and neurological defects compared with similarly treated wild-type mice
• after occlusion of the middle cerebral artery with a transluminal filament and reperfusion, infarct volume is reduced 34% compared to in similarly treated wild-type mice

homeostasis/metabolism
• mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exhibit a reduced decrease in dopamine levels compared with similarly treated wild-type mice
• mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exhibit a reduced decrease in dopamine levels compared with similarly treated wild-type mice (J:120035)
• treatment of primary lung fibroblasts with the calcium ionophore A23187 stimulates less arachidonic acid release from the cells than in wild-type cells but similar levels of lactate dehydrogenase release (J:278285)
• primary lung fibroblasts stimulated with hydrogen peroxide to stimulate release of arachidonic acid and lactate dehydrogenase release less arachidonic acid (25%) compared to wild-type fibroblasts (37%) but similar levels of lactate dehydrogenase (J:278285)
• mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exhibit reduced neuronal cell death compared with similarly treated wild-type mice
• following left main stem bronchus occlusion, mice fail to exhibit a change in left lung pulmonary vascular resistance and lower arterial partial pressure of oxygen compared to in similarly treated wild-type mice
• however, treatment with arachidonic acid, indomethacin, or L-NAME or chronic exposure to hypoxic conditions restore lower arterial partial pressure of oxygen increase observed during left main stem bronchus occlusion
• chronic hypoxia exposure results in less prominent right ventricle hypertrophy, less polycythemia, and restored hypoxic pulmonary vasoconstriction compared to in similarly treated wild-type mice
• mice exposed to 3 weeks of chronic hypoxic conditions then subjected to left main stem bronchus occlusion, exhibit lower left lung pulmonary vascular resistance compared with similarly treated wild-type mice
• aortic banding results in greater cardiac hypertrophy than in wild-type mice
• after occlusion of the middle cerebral artery with a transluminal filament and reperfusion, mice exhibit reduced brain edema and neurological defects compared with similarly treated wild-type mice
• after occlusion of the middle cerebral artery with a transluminal filament and reperfusion, infarct volume is reduced 34% compared to in similarly treated wild-type mice

hematopoietic system
• after 4 weeks in culture, more bone marrow-derived mast cells are generated than by wild-type samples
• in response to stem cell factor (SCF)
• chronic hypoxia exposure results in less polycythemia compared to in similarly treated wild-type mice

immune system
• after 4 weeks in culture, more bone marrow-derived mast cells are generated than by wild-type samples
• in response to stem cell factor (SCF)

cardiovascular system
N
• despite increased heart size, cardiac function is normal
• cardiomyocyte cross-sectional area is increased 17% compared to in wild-type mice
• aortic banding results in greater cardiac hypertrophy than in wild-type mice
• left ventricle posterior wall is thicker than in wild-type mice
• chronic hypoxia exposure results in less prominent right ventricle hypertrophy compared to in similarly treated wild-type mice
• following left main stem bronchus occlusion, mice fail to exhibit a change in left lung pulmonary vascular resistance unlike similarly treated wild-type mice 0
• however, treatment with arachidonic acid, indomethacin, or L-NAME or chronic exposure to hypoxic conditions restore lower arterial partial pressure of oxygen increase observed during left main stem bronchus occlusionhowever, treatment with arachidonic acid, indomethacin, or L-NAME or chronic exposure to hypoxic conditions restore lower arterial partial pressure of oxygen increase observed during left main stem bronchus occlusion
• mice exposed to 3 weeks of chronic hypoxic conditions then subjected to left main stem bronchus occlusion, exhibit lower left lung pulmonary vascular resistance compared with similarly treated wild-type mice
• aortic banding results in greater cardiac hypertrophy than in wild-type mice

muscle
• cardiomyocyte cross-sectional area is increased 17% compared to in wild-type mice
• skeletal myocyte cross-sectional area is increased 15.5% compared to in wild-type mice

cellular
• mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exhibit reduced neuronal cell death compared with similarly treated wild-type mice
• after 4 weeks in culture, more bone marrow-derived mast cells are generated than by wild-type samples
• in response to stem cell factor (SCF)
• pups of female mice are larger than normal and often die at birth
• litter size of female mice is decreased regardless of the parental genotype
• offspring of female mice mated with homozygous males die near implantation (E4.5)
• female mice produce fewer, smaller litters that often result in dead pups

growth/size/body
• aortic banding results in greater cardiac hypertrophy than in wild-type mice




Genotype
MGI:4358877
hm2
Allelic
Composition
Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic
Background
involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g4atm1Jvb mutation (0 available); any Pla2g4a mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• macrophage phagocytosis is normal




Genotype
MGI:4358789
hm3
Allelic
Composition
Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g4atm1Jvb mutation (0 available); any Pla2g4a mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• during water deprivation, mice exhibit a greater increase in plasma osmolality compared with similarly treated wild-type mice
• at P320, urine osmolality is decreased compared to in wild-type mice
• after water deprivation, mice exhibit decreased urine osmolality compared with similarly treated wild-type mice
• water deprived mice treated with vasopressin exhibit a decrease in urine osmolality compared with similarly treated wild-type mice
• however, water deprived mice respond normally to acute vasopressin treatment
• water deprived mice treated with vasopressin exhibit a decrease in urine osmolality compared with similarly treated wild-type mice
• however, water deprived mice respond normally to acute vasopressin treatment

growth/size/body
• during water deprivation, mice exhibit a greater loss in basal body weight compared with similarly treated wild-type mice

renal/urinary system
• at P320, urine osmolality is decreased compared to in wild-type mice
• after water deprivation, mice exhibit decreased urine osmolality compared with similarly treated wild-type mice
• water deprived mice treated with vasopressin exhibit a decrease in urine osmolality compared with similarly treated wild-type mice
• however, water deprived mice respond normally to acute vasopressin treatment




Genotype
MGI:4358796
hm4
Allelic
Composition
Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g4atm1Jvb mutation (0 available); any Pla2g4a mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• after 19 weeks of treatment with urethane, mice develop 43% fewer lung tumors compared with similarly treated wild-type mice

homeostasis/metabolism
• after 19 weeks of treatment with urethane, mice develop 43% fewer lung tumors compared with similarly treated wild-type mice




Genotype
MGI:4358774
cx5
Allelic
Composition
ApcMin/Apc+
Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic
Background
B6.Cg-Pla2g4atm1Jvb ApcMin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (154 available)
Pla2g4atm1Jvb mutation (0 available); any Pla2g4a mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• mice exhibit a 83% reduction in small intestine polyp number with a 22% decrease in size compared with polyps in ApcMin heterozygotes
• mice exhibit the same number of polyps in the large intestine as in ApcMin heterozygotes




Genotype
MGI:4358899
cx6
Allelic
Composition
Pla2g4atm1Jvb/Pla2g4a+
Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g4atm1Jvb mutation (0 available); any Pla2g4a mutation (61 available)
Zbtb20Tg(PDGFB-APPSwInd)20Lms mutation (1 available); any Zbtb20 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice do not exhibit premature death as do Tg(PDGFB-APPSwInd)20Lms mice

behavior/neurological
N
• mice do not exhibit the hyperactivity observed in Tg(PDGFB-APPSwInd)20Lms mice
• mice exhibit a complete or partial recovery of the learning deficits observed in Tg(PDGFB-APPSwInd)20Lms mice with improved target crossing in a Morris water maze
• mice exhibit disinhibition-like behaviors in an elevated plus maze compared with wild-type mice that are not as severe as in Tg(PDGFB-APPSwInd)20Lms mice




Genotype
MGI:4358900
cx7
Allelic
Composition
Pla2g4atm1Jvb/Pla2g4atm1Jvb
Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g4atm1Jvb mutation (0 available); any Pla2g4a mutation (61 available)
Zbtb20Tg(PDGFB-APPSwInd)20Lms mutation (1 available); any Zbtb20 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice do not exhibit premature death as do Tg(PDGFB-APPSwInd)20Lms mice

behavior/neurological
N
• mice do not exhibit the hyperactivity observed in Tg(PDGFB-APPSwInd)20Lms mice
• mice exhibit a complete or partial recovery of the learning deficits observed in Tg(PDGFB-APPSwInd)20Lms mice with improved target crossing in a Morris water maze
• mice exhibit disinhibition-like behaviors in an elevated plus maze compared with wild-type mice that are not as severe as in Tg(PDGFB-APPSwInd)20Lms mice





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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory