All Phenotypes Cd44<tm1Mak> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd44^tm1Mak/Cd44^tm1Mak	B6.129P2-Cd44^tm1Mak	MGI:4942353
hm2	Cd44^tm1Mak/Cd44^tm1Mak	D1.129P2-Cd44^tm1Mak	MGI:4943460
hm3	Cd44^tm1Mak/Cd44^tm1Mak	involves: 129P2/OlaHsd * C57BL/6	MGI:4944070
hm4	Cd44^tm1Mak/Cd44^tm1Mak	involves: 129P2/OlaHsd * C57BL/6J	MGI:3652584
ht5	Cd44^tm1Mak/Cd44⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:4943490
cx6	Apoe^tm1Unc/Apoe^tm1Unc Cd44^tm1Mak/Cd44^tm1Mak	B6.129P2-Cd44^tm1Mak Apoe^tm1Unc	MGI:4942387
cx7	Apoe^tm1Unc/Apoe^tm1Unc Cd44^tm1Mak/Cd44⁺	B6.129P2-Cd44^tm1Mak Apoe^tm1Unc	MGI:4942389
cx8	Cd44^tm1Mak/Cd44^tm1Mak Itgal^tm1Mak/Itgal^tm1Mak	B6.129P2-Cd44^tm1Mak Itgal^tm1Mak	MGI:4942402
cx9	Cd44^tm1Mak/Cd44^tm1Mak Tg(MMTV-PyVT)634Mul/0	B6.Cg-Cd44^tm1Mak Tg(MMTV-PyVT)634Mul	MGI:4943926
cx10	Cd44^tm1Mak/Cd44^tm1Mak Trp53^tm1Tyj/Trp53⁺	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J	MGI:4943188
cx11	Cd44^tm1Mak/Cd44^tm1Mak Met^tm1Cbm/Met⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:4946521
cx12	Cd44^tm1Mak/Cd44^tm1Mak Gab1^tm1Wbm/Gab1⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:4946522
cx13	Cd44^tm1Mak/Cd44^tm1Mak Tg(MMTV-PyVT)634Mul/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:4943925
cx14	Apc^Min/Apc⁺ Cd44^tm1Mak/Cd44^tm1Mak	involves: 129P2/OlaHsd * C57BL/6J	MGI:4946621
cx15	Cd44^tm1Mak/Cd44^tm1Mak Hgf^tm1Kita/Hgf⁺	involves: 129S4/SvJae * C57BL/6	MGI:4946523
cx16	Apc^Min/Apc⁺ Cd44^tm1Mak/Cd44^tm1Mak	involves: C57BL/6J	MGI:5544115

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

liver inflammation ( J:69351 )

• increased susceptibility to Concanavalin A (Con A)-induced hepatitis

• increased hepatocellular damage after Con A injection

• increased plasma aspartate aminotransferase levels, compared with WT mice

• similar active infiltration of mononuclear cells and neutrophils, compared with WT mice

• higher number of nuclei positive for DNA fragmentation in the liver compared with WT mice

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:69351 , J:111216 )

• all mice die within a few hours after Con A (20 mg/kg) injection, whereas WT mice survive (J:69351)

• more severe acute suppurative hepatitis after Con A (12 mg/kg) injection compared with WT mice (J:69351)

• increased mortality from lung injury (J:111216)

• 75% of mutant mice die by day 14, while wild-type mice survive but develop patchy lung fibrosis after bleomycin treatment (J:111216)

cellular

decreased sensitivity to induced cell death ( J:69351 )

• lower percentage of apoptotic liver-infiltrating mononuclear cells at 16 h after Con A administration, compared with cells from WT mice

decreased activation-induced cell death of T cells ( J:69351 )

• lower percentage of apoptotic T cells at 16 and 24 h after Con A administration, compared with WT mice

• lower percentage of apoptotic cells in T cells at 8, 16, and 24 h after cultured in vitro with Con A or immobilized anti-CD3 mAb plus IL-2, compared with cells from WT mice

abnormal leukocyte migration ( J:108245 )

• neutrophils migrated through Matrigel in response to chemoattractants faster and in greater numbers than wild-type neutrophils in vitro

impaired macrophage phagocytosis ( J:111216 )

• impaired ability of mutant macrophages to ingest apoptotic PMNs in vivo

• marked defect in clearance of exogenous apoptotic PMNs from BAL fluid compared to wild-type mice

• 13-fold increase in the number of apoptotic cells in the lung tissue of mutant mice compared to the wild type after bleomycin treatment

immune system

decreased activation-induced cell death of T cells ( J:69351 )

• lower percentage of apoptotic T cells at 16 and 24 h after Con A administration, compared with WT mice

• lower percentage of apoptotic cells in T cells at 8, 16, and 24 h after cultured in vitro with Con A or immobilized anti-CD3 mAb plus IL-2, compared with cells from WT mice

abnormal leukocyte migration ( J:108245 )

• neutrophils migrated through Matrigel in response to chemoattractants faster and in greater numbers than wild-type neutrophils in vitro

impaired macrophage phagocytosis ( J:111216 )

• impaired ability of mutant macrophages to ingest apoptotic PMNs in vivo

• marked defect in clearance of exogenous apoptotic PMNs from BAL fluid compared to wild-type mice

• 13-fold increase in the number of apoptotic cells in the lung tissue of mutant mice compared to the wild type after bleomycin treatment

impaired natural killer cell mediated cytotoxicity ( J:110889 )

• reduced IL-2-activated NK cytotoxicity against tumor cell lines

• impaired binding (conjugate formation) to target cells

• normal lymphocyte development and normal numbers of leukocyte subpopulations

• normal IL-2-activated NK cell differentiation and activation

abnormal circulating cytokine level ( J:69351 )

increased circulating interferon-gamma level ( J:69351 )

• increased production of IFN-gamma at 24 h after Con A administration, compared with WT mice

increased circulating interleukin-2 level ( J:69351 )

• increased production of IL-2 at 24 h after Con A administration, compared with WT mice

increased circulating tumor necrosis factor level ( J:69351 )

• increased production of TNF-alpha at 8 h after Con A administration, compared with WT mice

liver inflammation ( J:69351 )

• increased susceptibility to Concanavalin A (Con A)-induced hepatitis

• increased hepatocellular damage after Con A injection

• increased plasma aspartate aminotransferase levels, compared with WT mice

• similar active infiltration of mononuclear cells and neutrophils, compared with WT mice

• higher number of nuclei positive for DNA fragmentation in the liver compared with WT mice

lung inflammation ( J:108245 , J:111216 )

• more severe capillary disruption and more neutrophil accumulation in the lungs 6 hours after instillation of Escherichia coli, compared to wild-type mice (J:108245)

• greater edema formation during pneumonias induced by Escherichia coli (J:108245)

• normal circulating leukocyte counts (J:108245)

• normal clearance of instilled bacteria (J:108245)

• normal neutrophil apoptosis (J:108245)

• succumb to unremitting inflammation following noninfectious lung injury (J:111216)

• massive infiltration of inflammatory cells within alveolar interstitium until death by respiratory failure by day 14 after bleomycin treatment (J:111216)

• increased total cell numbers, polymorphonuclear leukocytes (PMNs), macrophages, and lymphocytes numbers in bronchoalveolar lavage (BAL) until death (J:111216)

• persisted hyaluronan (HA) accumulation and continue to rise until death within the interstitium intermixed with inflammatory cells (J:111216)

behavior/neurological

enhanced coordination ( J:80446 )

• improved motor function in spontaneous and forced motor performance (rotarod test)

cardiovascular system

decreased myocardial infarct size ( J:80446 )

• reduced ischemic infarct compared with that of wild-type mice following transient and permanent occlusion of the middle cerebral artery (MCAO)

• microglia and astrocytes are activated in a similar fashion

increased mean systemic arterial blood pressure ( J:80446 )

• increased mean arterial blood pressure, but in normal ranges compared with wild-type mice 30 min after reperfusion

• no difference in cerebral blood flow, heart rate, pH, blood oxygen and carbon dioxide between mutant and wild-type mice prior to and after transient MCAO

• no obvious difference in cardiovasculature and in particular the cerebral vasculature

homeostasis/metabolism

decreased myocardial infarct size ( J:80446 )

• reduced ischemic infarct compared with that of wild-type mice following transient and permanent occlusion of the middle cerebral artery (MCAO)

• microglia and astrocytes are activated in a similar fashion

abnormal circulating cytokine level ( J:69351 )

increased circulating interferon-gamma level ( J:69351 )

• increased production of IFN-gamma at 24 h after Con A administration, compared with WT mice

increased circulating interleukin-2 level ( J:69351 )

• increased production of IL-2 at 24 h after Con A administration, compared with WT mice

increased circulating tumor necrosis factor level ( J:69351 )

• increased production of TNF-alpha at 8 h after Con A administration, compared with WT mice

decreased transforming growth factor beta level ( J:111216 )

• much lower levels of active TGF-beta1 in BAL fluid relative to wild-type animals after bleomycin treatment

• similar total TGF-beta1 (latent + active) level

respiratory system

lung inflammation ( J:108245 , J:111216 )

• more severe capillary disruption and more neutrophil accumulation in the lungs 6 hours after instillation of Escherichia coli, compared to wild-type mice (J:108245)

• greater edema formation during pneumonias induced by Escherichia coli (J:108245)

• normal circulating leukocyte counts (J:108245)

• normal clearance of instilled bacteria (J:108245)

• normal neutrophil apoptosis (J:108245)

• succumb to unremitting inflammation following noninfectious lung injury (J:111216)

• massive infiltration of inflammatory cells within alveolar interstitium until death by respiratory failure by day 14 after bleomycin treatment (J:111216)

• increased total cell numbers, polymorphonuclear leukocytes (PMNs), macrophages, and lymphocytes numbers in bronchoalveolar lavage (BAL) until death (J:111216)

• persisted hyaluronan (HA) accumulation and continue to rise until death within the interstitium intermixed with inflammatory cells (J:111216)

hematopoietic system

decreased activation-induced cell death of T cells ( J:69351 )

• lower percentage of apoptotic T cells at 16 and 24 h after Con A administration, compared with WT mice

• lower percentage of apoptotic cells in T cells at 8, 16, and 24 h after cultured in vitro with Con A or immobilized anti-CD3 mAb plus IL-2, compared with cells from WT mice

abnormal leukocyte migration ( J:108245 )

• neutrophils migrated through Matrigel in response to chemoattractants faster and in greater numbers than wild-type neutrophils in vitro

impaired macrophage phagocytosis ( J:111216 )

• impaired ability of mutant macrophages to ingest apoptotic PMNs in vivo

• marked defect in clearance of exogenous apoptotic PMNs from BAL fluid compared to wild-type mice

• 13-fold increase in the number of apoptotic cells in the lung tissue of mutant mice compared to the wild type after bleomycin treatment

impaired natural killer cell mediated cytotoxicity ( J:110889 )

• reduced IL-2-activated NK cytotoxicity against tumor cell lines

• impaired binding (conjugate formation) to target cells

• normal lymphocyte development and normal numbers of leukocyte subpopulations

• normal IL-2-activated NK cell differentiation and activation

Allelic Composition	Cd44^tm1Mak/Cd44^tm1Mak
Genetic Background	D1.129P2-Cd44^tm1Mak

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44^tm1Mak mutation (1 available); any Cd44 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to induced arthritis ( J:95275 )

• more susceptible to collagen-induced arthritis (CIA) than wild-type mice

• develope arthritis 25 ([?]1) days after injection of a single dose (200 ug) of collagen

• more extensive chondrolysis

• enhanced accumulation of hyaluronan

skeleton

increased susceptibility to induced arthritis ( J:95275 )

• more susceptible to collagen-induced arthritis (CIA) than wild-type mice

• develope arthritis 25 ([?]1) days after injection of a single dose (200 ug) of collagen

• more extensive chondrolysis

• enhanced accumulation of hyaluronan

Allelic Composition	Cd44^tm1Mak/Cd44^tm1Mak
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44^tm1Mak mutation (1 available); any Cd44 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

decreased susceptibility to kidney reperfusion injury ( J:114341 )

• decreased renal injury after bilateral renal ischemia reperfusion (I/R)

• reduced histopathologic changes in the corticomedullary region, such as tubular necrosis, dilation, and loss of brush border

• 24 hrs after bilateral renal I/R injury, the increase in serum urea and creatinine levels is significantly prevented

• renal function is improved by approximately 50% compared with wild-type mice

• renal function is fully restored after 14 d, whereas renal function of the wild type is still impaired

immune system

peritoneal inflammation ( J:155691 )

• modestly increased bacterial load in peritoneal lavage fluid at 6 h after infection during E. coli peritonitis, compared to wild-type mice

• similar bacterial load in peritoneal lavage fluid 20 h after infection or in other body compartments

• no differences in the number of neutrophils or macrophages in the peritoneal cavity

• no effect in the severity of organ injury induced by abdominal sepsis

abnormal circulating chemokine level ( J:155691 )

• increased monocyte chemoattractant protein 2 (MCP-2) level in plasma at 6 h after infection during E. coli peritonitis

• decreased MCP-1 concentrations in plasma at 20 h after infection during E. coli peritonitis

decreased circulating tumor necrosis factor level ( J:155691 )

• decreased TNF-alpha concentrations in plasma at 20 h after infection during E. coli peritonitis

abnormal chemokine secretion ( J:155691 )

• enhanced peritoneal MCP-2, keratinocyte-derived cytokine, and LPS-induced CXC chemokine release at 6 h after infection during E. coli peritonitis

• trend towards enhanced peritoneal MCP-1 release at 20 h after infection during E. coli peritonitis

abnormal interleukin secretion ( J:155691 )

increased interleukin-1 beta secretion ( J:155691 )

• trend towards enhanced peritoneal IL-1beta release at 20 h after infection during E. coli peritonitis

increased interleukin-10 secretion ( J:155691 )

• trend towards enhanced peritoneal IL-10 release at 20 h after infection during E. coli peritonitis

increased interleukin-6 secretion ( J:155691 )

• enhanced peritoneal IL-6 release at 20 h after infection during E. coli peritonitis

increased tumor necrosis factor secretion ( J:155691 )

• enhanced peritoneal TNF-alpha release at 20 h after infection during E. coli peritonitis

decreased acute inflammation ( J:114341 )

• reduced influx of neutrophils and macrophage into the postischemic kidney 1 d after I/R

• similar total leukocyte, neutrophil, lymphocyte or monocyte counts in peripheral blood

cardiovascular system

abnormal vascular endothelial cell morphology ( J:110162 )

• absence of cellular ruffling and an irregular surface punctuated by retracted cells and/or very thin or flattened endothelial cells in the vessels invading subcutaneous Matrigel implants

• few pinocytotic vesicle in the microvessels

abnormal physiological neovascularization ( J:110162 )

• reduced (20%) density of vessels at the edge of the wounds on day 3

• similar leukocyte recruitment compared with wild type

decreased angiogenesis ( J:110162 )

• reduced vessel densities of tumors compared to that of tumors in wild-type animals after subcutaneous injection of the B16 melanoma line and an ovarian tumor line

• similar leukocyte recruitment compared with wild type

abnormal vasculogenesis ( J:110162 )

• reduced vascularization around and within subcutaneously implanted Matrigel plugs containing B16 tumor cells

abnormal vascular endothelial cell physiology ( J:110162 )

• decreased ability of the mutant endothelial cells to form tubular networks on Matrigel in vitro

• normal hyaluronan adhesion, proliferation, migration, and susceptibility to apoptotic stress in endothelial cells

neoplasm

decreased tumor growth/size ( J:110162 )

• reduced (>70%) weight of both tumors compared to that of tumors in wild-type animals after subcutaneous injection of the B16 melanoma line and an ovarian tumor line

nervous system

abnormal miniature excitatory postsynaptic currents ( J:128984 )

• severe impairment of excitatory synaptic transmission in preBotC neurons

increased miniature excitatory postsynaptic current amplitude ( J:128984 )

• moderately increased amplitude of glutamatergic mEPSCs in preBotC neurons

decreased miniature excitatory postsynaptic current frequency ( J:128984 )

• decreased frequency of glutamatergic mEPSCs in preBotC neurons

digestive/alimentary system

peritoneal inflammation ( J:155691 )

• no effect in the severity of organ injury induced by abdominal sepsis

• modestly increased bacterial load in peritoneal lavage fluid at 6 h after infection during E. coli peritonitis, compared to wild-type mice

• similar bacterial load in peritoneal lavage fluid 20 h after infection or in other body compartments

• no differences in the number of neutrophils or macrophages in the peritoneal cavity

homeostasis/metabolism

decreased circulating creatinine level ( J:114341 )

• twenty-four hours after bilateral renal I/R injury, the increase in serum creatinine levels is significantly prevented

• renal function is improved by approximately 50% compared with wild-type mice

• renal function is fully restored after 14 d, whereas renal function of the wild type is still impaired

decreased blood urea nitrogen level ( J:114341 )

• twenty-four hours after bilateral renal I/R injury, the increase in serum urea levels is significantly prevented

• renal function is improved by approximately 50% compared with wild-type mice

• renal function is fully restored after 14 d, whereas renal function of the wild type is still impaired

abnormal circulating chemokine level ( J:155691 )

• increased monocyte chemoattractant protein 2 (MCP-2) level in plasma at 6 h after infection during E. coli peritonitis

• decreased MCP-1 concentrations in plasma at 20 h after infection during E. coli peritonitis

decreased circulating tumor necrosis factor level ( J:155691 )

• decreased TNF-alpha concentrations in plasma at 20 h after infection during E. coli peritonitis

decreased susceptibility to kidney reperfusion injury ( J:114341 )

• decreased renal injury after bilateral renal ischemia reperfusion (I/R)

• reduced histopathologic changes in the corticomedullary region, such as tubular necrosis, dilation, and loss of brush border

• 24 hrs after bilateral renal I/R injury, the increase in serum urea and creatinine levels is significantly prevented

• renal function is improved by approximately 50% compared with wild-type mice

• renal function is fully restored after 14 d, whereas renal function of the wild type is still impaired

delayed wound healing ( J:110162 )

• delayed wound closure during days 1 to 3 after wounding

• by day 7 have recovered and is similar to that of wild-type animals

Allelic Composition	Cd44^tm1Mak/Cd44^tm1Mak
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44^tm1Mak mutation (1 available); any Cd44 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal leukocyte migration ( J:99032 )

• lower proportion of polarized cells in all directions or the direction of the N-formyl methionyl leucyl phenylalanine (fMLP) in the pool of mutant freshly isolated neutrophils compared with wild-type cells

• much more slower migration speed respond to fMLP stimulation and show random movement

• reduced numbers of neutrophil infiltrating the peritoneal cavity in response to fMLP and thioglycollate in vivo

abnormal definitive hematopoiesis ( J:72658 )

• altered tissue distribution of myeloid progenitors with increased levels of colony-forming unit-granulocyte-macrophage (CFU-GM) in bone marrow and reduced numbers of CFU-GM and CFU-macrophage (CFU-M) in spleen

• total number of colonies and the number of CFU-GM in the spleen after mobilization are reduced even further, whereas the number of all other hematopoietic progenitors from spleen and bone marrow are similar to controls

immune system

immune system phenotype ( J:72658 )

N	• exhibit normal white blood cell counts, lymphocyte subsets in spleen and lymph nodes, thymocyte counts, Ig levels, and responses to VSV infection

abnormal leukocyte migration ( J:99032 )

• much more slower migration speed respond to fMLP stimulation and show random movement

• reduced numbers of neutrophil infiltrating the peritoneal cavity in response to fMLP and thioglycollate in vivo

increased susceptibility to parasitic infection ( J:72658 )

• develop exaggerated granuloma responses to Cryotosporidium parvum infection, with larger and greater numbers of granulomas

cellular

abnormal cell morphology ( J:105319 )

• cytoplasmic vacuolization in cultured primary fibroblasts, along with polygonal cell morphology

abnormal mitochondrial crista morphology ( J:105319 )

• mitochondria contain disrupted cristae in matrix

increased mitochondrial size ( J:105319 )

• enlarged mitochondria in colonocytes

abnormal cell physiology ( J:72658 )

• SV50-transformed mutant fibroblasts are more highly tumorigenic in nude mice than control fibroblasts

abnormal leukocyte migration ( J:99032 )

• much more slower migration speed respond to fMLP stimulation and show random movement

• reduced numbers of neutrophil infiltrating the peritoneal cavity in response to fMLP and thioglycollate in vivo

decreased fibroblast proliferation ( J:105319 )

• 50% decrease in the growth of viable cultured primary fibroblasts, compared with cells from wild-type mice

muscle

abnormal vascular smooth muscle physiology ( J:101783 )

• isolated smooth muscle cells exhibit impaired ability to compact collagen gels, to assemble fibrillar collagen from exogenous monomers, and to attach to gelatin

cardiovascular system

abnormal vascular smooth muscle physiology ( J:101783 )

• isolated smooth muscle cells exhibit impaired ability to compact collagen gels, to assemble fibrillar collagen from exogenous monomers, and to attach to gelatin

Allelic Composition	Cd44^tm1Mak/Cd44⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44^tm1Mak mutation (1 available); any Cd44 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal leukocyte migration ( J:99032 )

• trend towards decreased N-formyl methionyl leucyl phenylalanine (fMLP)-directed polarization in the pool of freshly isolated neutrophils compared with wild-type cells

• trend towards slower migration speed

• reduced numbers of neutrophil infiltrating the peritoneal cavity in response to thioglycollate in vivo

• trend towards reduced numbers of neutrophil in response to fMLP in vivo

cellular

abnormal leukocyte migration ( J:99032 )

• trend towards decreased N-formyl methionyl leucyl phenylalanine (fMLP)-directed polarization in the pool of freshly isolated neutrophils compared with wild-type cells

• trend towards slower migration speed

• reduced numbers of neutrophil infiltrating the peritoneal cavity in response to thioglycollate in vivo

• trend towards reduced numbers of neutrophil in response to fMLP in vivo

hematopoietic system

abnormal leukocyte migration ( J:99032 )

• trend towards decreased N-formyl methionyl leucyl phenylalanine (fMLP)-directed polarization in the pool of freshly isolated neutrophils compared with wild-type cells

• trend towards slower migration speed

• reduced numbers of neutrophil infiltrating the peritoneal cavity in response to thioglycollate in vivo

• trend towards reduced numbers of neutrophil in response to fMLP in vivo

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Cd44^tm1Mak/Cd44^tm1Mak
Genetic Background	B6.129P2-Cd44^tm1Mak Apoe^tm1Unc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (145 available)
Cd44^tm1Mak mutation (1 available); any Cd44 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:72315 )

• reduced lesion area in the aortic root and thoracic abdominal aorta in a gene dosage-dependent manner

• normal plasma cholesterol levels

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Cd44^tm1Mak/Cd44⁺
Genetic Background	B6.129P2-Cd44^tm1Mak Apoe^tm1Unc

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:72315 )

• reduced lesion area in the thoracic abdominal aorta

• normal plasma cholesterol levels

Allelic Composition	Cd44^tm1Mak/Cd44^tm1Mak Itgal^tm1Mak/Itgal^tm1Mak
Genetic Background	B6.129P2-Cd44^tm1Mak Itgal^tm1Mak

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44^tm1Mak mutation (1 available); any Cd44 mutation (67 available)
Itgal^tm1Mak mutation (2 available); any Itgal mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired natural killer cell mediated cytotoxicity ( J:110889 )

• further reduced IL-2-activated NK cytotoxicity against tumor cell lines than that of the single mutation mice

• further impaired binding (conjugate formation) to target cells than that of the single mutation mice

• normal lymphocyte development and normal numbers of leukocyte subpopulations

• normal IL-2-activated NK cell differentiation and activation

hematopoietic system

impaired natural killer cell mediated cytotoxicity ( J:110889 )

• further reduced IL-2-activated NK cytotoxicity against tumor cell lines than that of the single mutation mice

• further impaired binding (conjugate formation) to target cells than that of the single mutation mice

• normal lymphocyte development and normal numbers of leukocyte subpopulations

• normal IL-2-activated NK cell differentiation and activation

Allelic Composition	Cd44^tm1Mak/Cd44^tm1Mak Tg(MMTV-PyVT)634Mul/0
Genetic Background	B6.Cg-Cd44^tm1Mak Tg(MMTV-PyVT)634Mul

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44^tm1Mak mutation (1 available); any Cd44 mutation (67 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased metastatic potential ( J:100774 )

• an increase in the percentage of mice developing metastases at 14 weeks, compared with Cd44^tm1Mak/+, Tg(MMTV-PyVT)634Mul mice

• a greater number of metastases per lung

Allelic Composition	Cd44^tm1Mak/Cd44^tm1Mak Trp53^tm1Tyj/Trp53⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44^tm1Mak mutation (1 available); any Cd44 mutation (67 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased metastatic potential ( J:76201 )

• osteosarcoma on the lower back and on the skull, with significantly decreased metastasis

• incidence of ibrosarcomas, osteosarcomas, hemangiosarcomas, and histiocytic sarcomas, associated life span, and tumor weight on death are not affected

increased lymphoma incidence ( J:76201 )

• 17% have lymphoma, typical of those observed in Trp53^tm1Tyj/+ mice

• 23% have lymphomas, resembling anaplastic large cell lymphomas

• lymphoma is seen in conjunction with osteosarcoma, fibrosarcoma, and histiocytic sarcoma

Allelic Composition	Cd44^tm1Mak/Cd44^tm1Mak Met^tm1Cbm/Met⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44^tm1Mak mutation (1 available); any Cd44 mutation (67 available)
Met^tm1Cbm mutation (0 available); any Met mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality, incomplete penetrance ( J:128984 )

• shortly after birth, 70% of the animals die of breathing difficulties

neonatal lethality, incomplete penetrance ( J:128984 )

• shortly after birth, 70% of the animals die of breathing difficulties

respiratory system

primary atelectasis ( J:128984 )

• multifocal atelectasis in the lung caused by a primary asphyxia

• in 76% of the mutant animals, the lungs sank, indicating that they are not inflated

respiratory distress ( J:128984 )

• shortly after birth, 70% of the animals die of breathing difficulties

nervous system

abnormal phrenic nerve morphology ( J:128984 )

• individual Schwann cell profiles ensheath more axons than in control mice

• less Schwann cell profiles than in controls ensheath only one axon

• increased number of Schwann cells associated with bundles of axons without intervening Schwann cell processes

• reduced number of segregated axons

• decreased percentage of segregated axons with a diameter size between 0.75 to 1.00 um

• slightly increased percentage of small (<0.75 um) and large (>1.00 um) caliber axons

abnormal miniature excitatory postsynaptic currents ( J:128984 )

• even more severe impairment of excitatory synaptic transmission in preBotC neurons

• decreased frequency of glutamatergic mEPSCs in preBotC neurons, compare with Cd44^tm1Mak homozygous mice

• moderately decreased amplitude

abnormal miniature inhibitory postsynaptic currents ( J:128984 )

• reduced spontaneous postsynaptic currents (sPSCs) in preBotC neurons

• amplitudes are not changed

decreased miniature inhibitory postsynaptic current frequency ( J:128984 )

• decreased frequency of glycinergic and GABAergic miniature mIPSCs in preBotC neurons

Allelic Composition	Cd44^tm1Mak/Cd44^tm1Mak Gab1^tm1Wbm/Gab1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44^tm1Mak mutation (1 available); any Cd44 mutation (67 available)
Gab1^tm1Wbm mutation (0 available); any Gab1 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality, incomplete penetrance ( J:128984 )

• shortly after birth, 60% of the animals die

neonatal lethality, incomplete penetrance ( J:128984 )

• shortly after birth, 60% of the animals die

Allelic Composition	Cd44^tm1Mak/Cd44^tm1Mak Tg(MMTV-PyVT)634Mul/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44^tm1Mak mutation (1 available); any Cd44 mutation (67 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased metastatic potential ( J:100774 )

• an increase in the percentage of mice developing metastases at 14 weeks, compared with Cd44^tm1Mak/+, Tg(MMTV-PyVT)634Mul mice

• a greater number of metastases per lung

• similar tumor onset or size in breast

• similar hyaluronan deposition in the pulmonary metastases

Allelic Composition	Apc^Min/Apc⁺ Cd44^tm1Mak/Cd44^tm1Mak
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (154 available)
Cd44^tm1Mak mutation (1 available); any Cd44 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased intestinal adenoma incidence ( J:135025 )

• an almost 50% reduction in intestinal adenoma number at 16 weeks

• strongly reduced number of aberrant crypts both at 8 weeks and at 16 weeks

• no change in mean adenoma diameter

digestive/alimentary system

increased small intestinal crypt cell apoptosis ( J:135025 )

• increased number of apoptotic cells in the intestinal crypt compartments shown by cleaved caspase-3 staining

• majority of these positive cells are localized below the transit-amplifying zone in the basal crypt compartment, between Paneth cells

• no change in proliferation

decreased intestinal adenoma incidence ( J:135025 )

• an almost 50% reduction in intestinal adenoma number at 16 weeks

• strongly reduced number of aberrant crypts both at 8 weeks and at 16 weeks

• no change in mean adenoma diameter

cellular

increased small intestinal crypt cell apoptosis ( J:135025 )

• increased number of apoptotic cells in the intestinal crypt compartments shown by cleaved caspase-3 staining

• majority of these positive cells are localized below the transit-amplifying zone in the basal crypt compartment, between Paneth cells

• no change in proliferation

Allelic Composition	Cd44^tm1Mak/Cd44^tm1Mak Hgf^tm1Kita/Hgf⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44^tm1Mak mutation (1 available); any Cd44 mutation (67 available)
Hgf^tm1Kita mutation (0 available); any Hgf mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:128984 )

• shortly after birth, 69% of the animals die

Allelic Composition	Apc^Min/Apc⁺ Cd44^tm1Mak/Cd44^tm1Mak
Genetic Background	involves: C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased tumor-free survival time ( J:204874 )

• mice survive longer than Apc^Min heterozygotes

neoplasm

decreased intestinal adenoma incidence ( J:204874 )

• decreased adenoma and microadenoma compared with Apc^Min heterozygotes without a change in intestinal crypt apoptosis and proliferation rates

digestive/alimentary system

increased enterocyte apoptosis ( J:204874 )

• compared with Apc^Min heterozygotes

decreased intestinal adenoma incidence ( J:204874 )

• decreased adenoma and microadenoma compared with Apc^Min heterozygotes without a change in intestinal crypt apoptosis and proliferation rates

cellular

increased enterocyte apoptosis ( J:204874 )

• compared with Apc^Min heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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